Abstract
The biochemical mechanisms that induce target cell lysis in cell mediated cytotoxicity systems—cytotoxic T-lymphocytes, natural killer cells, natural cytotoxicity cells, antibody dependent cell mediated cytotoxicity systems, and cytotoxic activated macrophages—are unknown. Identification of the biochemical effector mechanism(s) utilized by activated macrophages to induce stasis and lysis of transformed target cells is complicated by the large armamentarium of potential cytotoxic effector molecules that can be elaborated by macrophages. Evidence of activated macrophage mediated target cell cytotoxicity-cytostasis and cytolysis—has been observed and documented most extensively with techniques suitable for analysis of biologic phenomena at the cellular level. Observation at the cellular level has not provided evidence that demonstrates, in a definitive way, which potential effector molecules, among the many elaborated by macrophages, are relevant to the destruction of nucleated mammalian cells or to control of abnormal proliferation of mammalian cells in vivo.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Granger, D.L., Taintor, R.R., Cook, J.L., and J.B. Hibbs, Jr. Injury of neoplatic cells by murine macrophages leads to inhibition of mitochondrial respiration. J. Clin. Invest. 65:357 (1980).
Hibbs, J.B., Jr., Lambert, L.H., Jr., and J.S. Remington. Control of carcinogenesis: A possible role for the activated macrophage. Science 177:998 (1972).
Meitzer, M.S., Tucker, R.W., and A.C. Breur. Interaction of BCG-activated macrophages with neoplastic and nonneoplastic cell lines - in vitro: Cinemicrographic analysis. Cell. Immunol. 17:30 (1975).
Keller, R. Cytostatic elimination of syngeneic rat tumor cells in vitro by nonspecifically activated macrophages. J. Exp. Med. 138:625 (1973).
Krahenbuhl, J.L., and J.S. Remington. The role of activated marcophages in specific and nonspecific cytostasis of tumor cells. J. Immunol. 113:507 (1974).
Krahenbuhl, J.L. Effects of activated macrophages of tumor target cells in discrete phases of the cell cycle. Cancer Res. 40:4622 (1980).
Kaplan, A.M., Brown, J., Collins, J.M., Morahan, P.S., and M.J. Snodgrass. Mechanism of macrophage-mediated tumor cell cytotoxicity. J. Immunol. 121:1781 (1978).
Skipper, H.E., Schabel, F.M., Jr., and W.S. Wilcox. Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with “curability” of experimental leukemia. Cancer Chemother. Rep. 35:1 (1964).
Hibbs, J.B., Jr., Lambert, L.H., Jr., and J.S. Remington. Resistance to murine tumors conferred by chronic infection with intracellular protozoa. Toxoplasma gondii and Bemitia jellisonii. J. Infect. Dis. 124:587 (1971).
Lehninger, A.L. Biochemistry. Worth Publishers, Inc., New York, p. 387 (1975).
Slater, E.C. Application of inhbitors and uncouplers for study of oxidastive phosphorylation. Methods Enzymol. 10: 48 (1967).
Racker, E. Lecture 4: The coupling device: J “A New Look at Mechanisms in Bioenergetics,” Academic Press, Inc., New York, p. 67 (1976).
Granger, D.L., and J.B. Hibbs, Jr. Recovery from injury incurred by leukemia cells in contact with activated macrophages. Fed. Proc. 40:761 (1981).
Lewis, A.M., Jr., and J.L. Cook. Presence of allograft- rejection resistance in simian virus 40-transformed hamster cells and its possible role in tumor development. Proc. Natl. Acad. Sci. USA 77:2889 (1980)
Butel, J.S., Tenethia, S.S., and J.L. Melnick. Oncogenicity and cell transformation by papovavirus SV40: The role the viral genome. Adv. in Cancer Res. 15:1 (1972).
Duncan, W.R., and J.W. Streilein. Analysis of the major histocompatibility complex in Syrian hamsters. Transplantation 25: 12 (1978).
Cook J.L., Hibbs, J.B., Jr., and A.M. Lewis, Jr. Resistance of simian virus 40-transformed hamster cells to the cytolytic, effect of activated macrophages: A possible factor in species- specific viral oncogenicity. Proc. Natl. Acad. Sci. USA 77:6773 (1980).
Zbar, B., Wepsic, H.T., Borsos, T., and H.J. Rapp. Tumor graft rejection in sjmgeneic guinea pigs: Evidence for a two-step mechanism. J. Nat. Cancer Inst. 44:473 (1970).
Hibbs, J.B., Jr. Macrophage nonimmunologic recognition: Target cell factors related to contact inhibition. Science 180:868 (1973).
Hibbs, J.B., Jr., Chapman, H.A., Jr., and J.B. Weinberg. The macrophage as an antineoplastic surveillance cell: Biologic perspectives. J. Reticuloendothelial Soc. 24:549 (1978).
Hibbs, J.B., Jr. Heterocytolysis by macrophages activated by bacillus Calmette-Guerin: Lysosome exocytosis into tumor cells. Science 184:468 (1974).
Bucana, C., Hoyer, L.C., Hobbs, B., Breesman, S., McDaniel, M., and M.G. Hanna. Morphological evidence for the translocation of lysosomal organelles from cytotoxic macrophages into the cytoplasm of tumor target cells. Cancer Res. 36:4444 (1976).
Otto, K. Cathespins Bi and B2. “Tissue Proteinases,” edited by A.J. Barrett and J.T. Dingle. North-Holland Publishing Co., Amsterdam, p. 1 (1971).
Adams, D.O. Effector mechanism of cytolytically activated macrophages. I. Secretion of neutral proteases and effect of protease inhibitors. J. Immunol. 124:286 (1980).
Hibbs, J.B., Jr., Taintor, R.R., Chapman, H.A., Jr., and J.B. Weinberg. Macrophage tumor cell killing: Influence of the local environment. Science 197:279 (1977).
Chang, T.W., and H.N. Eisen. Effects of TLCK bn the activity of cytotoxic lymphocytes. J. Immunol. 124:1028 (1980).
Martz, E. Mechanism of specific tumor cell lysis by allo- immune T-lymphocytes: Resolution and characterization of discrete steps in the cellular interaction. Contemp. Top. Immunol. 7:301 (1977).
Roder, JC., Argov, S., Klein, M., Petersson, C., Kiessling, R., Anderson, K., and M. Hansson. Target-effector cell interaction in the natural killer cell system. V. Energy requirements, membrane integrity, and the possible involvement of lysosomal enzymes. Immunology 40:107 (1980).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Hibbs, J.B., Granger, D.L., Cook, J.L., Lewis, A.M. (1982). Activated Macrophage Mediated Cytotoxicity for Transformed Target Cells. In: Clark, W.R., Golstein, P. (eds) Mechanisms of Cell-Mediated Cytotoxicity. Advances in Experimental Medicine and Biology, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8959-0_17
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8959-0_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8961-3
Online ISBN: 978-1-4684-8959-0
eBook Packages: Springer Book Archive