Abstract
In ADCC, recognition of the target cells is mediated by IgG antibodies. Available evidence also suggests that target cell lysis is triggered by the interaction of Fc structures of the inducing IgG with the Fcγ-receptors of the killer cell (1). Target cell recognition and triggering of lysis would thus appear to be linked but independent reactions. In the following I will discuss some additional recognition phenomena which are independent of the inducing antibody but which nevertheless are important in regulating killer cell — target cell interaction ADCC. We call this “associative recognition” and I will discuss four examples, three from our own work and one from the work of others.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Perlmann, P. and J.C. Cerottini. Cytotoxic lymphocytes. In “The Antigens,” Vol. 5, M. Sela (ed.), p. 173. Academic Press, Inc., New York (1979).
Perlmann, H., Perlmann, J, Schreiber, R.C., and H.G. Muller-Eberhard. Interaction of target cell-bound C3bi and C3d with human lymphocytes receptors. J. Exp. Med. 153:1592 (1981).
Wahlin, B., and P. Perlmann. Detection of K-cells by a plaque assay. In “In vitro methods in cell mediated and tumor immunity,” B. Bloom and J.R. David (eds.)., p. 523. Academic Press, Inc., New York (1976).
Wahlin, B., Perlmann, H., Perlmann, P., Schreiber, R.D., and H.J. Muller-Eberhard. Human K-cells. Distribution of receptors for Geb, C3bi and C3d and the ADCC regulatory function of these fragments. J. Immunol., submitted (1982).
Perlmann, H., Perlmann, P., Moretta, L., and M. Ronnholm. Regulation of IgG antibody-dependent cellular cytotoxicity in vitro by IgM antibodies. Scand. J. Immunol. 14:47 (1981).
Ohlander, C., Perlmann, H., and P. Perlmann. Regulation of IgG-IgM interplay by antibody specificity in human K-cell mediated cytotoxicity. Scand. J. Immunol, (in press) (1982).
Merrill, J.E., Biberfeld, G., Holmodin, G., Landin, S., and E. Norrby. A T-lymphocyte subpopulation in multiple sclerosis patients bearing Fc-receptors for both IgG and IgM. J. Immunol. 124:2758 (1980).
Harfast, B., Orvell, C., Alsheikhly, A., Andersson, T., Perlmann, P. and E. Norrby. The role of viral glycoproteins in mumps-virus dependent lymphocyte mediated cytotoxicity in vitro. Scand. J. Immunol. 11:391 (1980).
Alsheikhly, A., Orvell, C., Harfast, B., Andersson, T., Norrby, E., and P. Perlmann. Sendai virus dependent cellular cytotoxicity in vitro. The Role of viral glycoproteins. Scand. J. Immunol, (in press) (1982).
Fuson, E.W., Shaw, M.W., Hubbard, R.A., and E.W. Lamon. Anti- body-antigen complex stimulated lysis of non-sensitized sheep red blood cells by human lymphocytes. Clin. Exp. Immunol. 38: 158 (1979).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Perlmann, P. (1982). Associative Recognition in ADCC. In: Clark, W.R., Golstein, P. (eds) Mechanisms of Cell-Mediated Cytotoxicity. Advances in Experimental Medicine and Biology, vol 146. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8959-0_14
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8959-0_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8961-3
Online ISBN: 978-1-4684-8959-0
eBook Packages: Springer Book Archive