Morphological Aspects of Lymphocyte Mediated Cytotoxicity

  • Colin J. Sanderson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 146)


In this review I am going to discuss the contact-mediated killing of nucleated mammalian cells by cytotoxic T cells (Tc cells) and antibody-dependent K cells. I wish to suggest that the mechanism of killing by Tc cells and K cells is similar, although a different receptor-ligand interaction is involved in the two types of killing. Tc cells have a specific receptor which reacts with antigen on the target cell while K cells have an Fc receptor reacting with antibody on the surface of the target cell. Because of apparent similarities between NK cells and K cells it is possible that all three classes of lymphoid cell share the same mechanism of killing.


Target Cell Effector Cell Lethal Event Cell Mediate Cytotoxicity Antibody Dependent Cell Mediate Cytotoxicity 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Colin J. Sanderson
    • 1
  1. 1.National Institute for Medical ResearchMill Hill, LondonUK

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