Abstract
In the last years growing interest has been focused on the pathogenesis of the glomerular diseases characterized by mesangial IgA deposits. Some pathogenetic mechanisms are common to all these nephropathies, either idiopatic or those associated to systemic disorders. Moreover, the analysis of individual diseases shows that their relative weight may be different, and this allows to consider at the same time at least a few of their pathogenetic mechanisms.
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Bibliografia
Berger, J., 1969, IgA glomerular deposits in renal disease. Transplant Proc 1: 939.
Emancipator, S.N., Gallo, G.R., Lamm, M.E., 1985, IgA nephropathy: perspectives on pathogenesis and classification. Clin Nephrol 24: 161.
Coppo, R., Basolo, B., Martina, G., Rollino, C., De Marchi, M., Giacchino, F., Mazzucco, G., Messina, M., Piccoli, G., 1982, Circulating immune complexes containing IgA, IgG and IgM in patients with primary IgA nephropathy and with Henoch-Schoenlein nephritis: Correlation with clinic and histologic signs of activity. Clin Neohrol 18: 230.
Lesavre, P., Digeon, M., Bach, J.F., 1982, Analysis of circulating IgA and detection of immune complexes in primary IgA nephropathy. Clin Exp Immunol 48: 61.
Valentijn, R.M., Kauffmann, R.H., Brutel de la Riviere, G., Daha, M. R., Van Es, L.A., 1983, Presence of circulating macromolecular IgA in patients with hematuria due to primary IgA nephropathy. Am J Med 74: 375.
Hall, R.P., Stachura, I., Cason, J., Whiteside, T.L., Lawley, T.L., 1983, IgA-containing circulating immune complexes in patients with IgA nephropathy. Am J Med 74: 56.
Egido, J., Sancho, J., Rivera, F., Hernando, L., 1984, The role of IgA and IgG immune complexes in IgA nephropathy. Nephron 36: 52.
Coppo, R., Basolo, B., Roccatello, D., Piccoli, G., 1985, Circulating immune complexes in immunologically mediated glomerular diseases. Contr Nephrol 48: 137.
Coppo, R., Basolo, B., Piccoli, G., Mazzucco, G., Bulzomi, M.R., Roccatello, D., De Marchi, M., Carbonara, A.O., Barbiano di Belgioioso, G., 1984, IgA1 and IgA2 immune complexes in primary IgA nephropathy and Henoch-Schoenlein nephritis. Clin Exp Immunol 57: 583.
Coppo, R., Arico, S., Piccoli, G., Basolo, B., Roccatello, D., Amore, A., Tabone, M., De La Pierre, M., Sessa, A., Delacroix, D., L., Verman, J.P., 1985, Presence and origin of IgA1- and lgA2-containing circulating immune complexes in chronic alcoholic liver diseases with and without glomerulonephritis. Clin Immunol Immunopathol 35: 1.
Breda Vriesman, P., Tiebosch, T., 1987, Idiopathic IgA nephropathy: a local immune complex disease? (Abs) XXIVth Congress of EDTA-Eurooean Renal Association, p 89.
Feehally, J., Beattie, T.J., Brenchley, P.E.C., Coupes, B.M., Mallick, N.P., Postlethwaite, R.J., 1986, Sequential study of the IgA system in relapsing IgA nephropathy. Kidney Int 30, 924.
Egido, J., Blasco, R., Sancho, J., Lozano, T., 1983, T cell dysfunctions in IgA nephropathy: specific abnormalities in the regulation of IgA synthesis. Clin Immunol Immunopathol 26: 201.
Lopez-Trascasa, M., Egido, J., Sancho, J., Hernando, L., 1980, IgA glomerulonephritis (Berger’s disease): evidence of high serum levels of polymeric IgA. Clin Exp Immunol 42: 247.
Danielsen, H., Eriksen, E.F., Johansen, A., Solling, J., 1984, Serum immunoglobulin sedimentation patterns and circulating immune complexes in IgA nephropathy and Schoenlein-Henoch nephritis. Acta Med Scand 215: 435.
Nomoto, Y., Sakai, H., Arimori, S., 1979, Increase of IgA bearing lymphocytes in peripheral blood from patients with IgA nephropathy. Am J Clin Path 71: 158.
Drew, P.A., Nieuwhof, N., Clarkson, A.R., Woodroffe, A.J., 1987, Increased concentration of serum IgA antibody to Pneumococcal polisaccarides in patients with IgA nephropathy. Clin Exp Immunol 67:124.
Nagy, J., Vj, M., Szucs, G., Trinn, C., 1984, Herper virus antigens and antibodies in kidney biopsies and sera of IgA glomerulonephritic patients. Clin Nephrol 21: 259.
Woodroffe, A.J., Gormly, A.A., McKenzie, P.E., Clarkson, A.R., 1980, Immunologic studies In IgA nephropathy. Kidnev Int 18: 342.
Hale, G.M., Mcintosh, S.L., Hiki, Y., Clarkson, A.R., Woodroffe, A.J., 1986, Evidence for IgA-specific B cell hyperreactivity in patients with IgA nephropathy. Kidney Int 29: 718.
Nagy, J., Scott, H., Brandtzaeg, P., 1987, Food antigens in the pathogenesis of IgA nephropathy. (Abs) XXIVth Congress of EDTA-European Renal Association, p 39.
Endoh, A., Suga, T., Miura, M., 1983, In vivo altaration of antibody production in patients with IgA nephropathy. Clin Exp Immunol 57: 564.
Nomoto, Y., Sakai, H., 1979, Cold reacting antinuclear factor in sera from patients with IgA nephropathy. J Lab Clin Med 94: 76.
Jackson, S., Montgomery, R.I., Julian, B.A., Galla, J.H., Czerninsky, C., 1987, Aberrant synthesis of antibodies directed at the Fab fragment of IgA In patients with IgA nephropathies. Clin Immunol Immunopathol 45: 208.
Valentijn, R.M., Radl, J., Haaijnon, J.J., 1984, Circulating and mesangial secretory component-binding IgA-j, in primary IgA nephropathy. Kidnev Int 26: 760.
Komatsu, N., Nagura, H., Watanabe, K., Nomoto, Y., Kobayashi, K., 1983, Mesangial deposition of J chain-linked polymeric IgA in IgA nephropathy. Nephron 33: 61.
Rifai, A., Millard, K., 1985, Glomerular deposition of immune complexes prepared with monomeric or polymeric IgA. Clin Exp Immunol 60: 363.
Emancipator, S.N., Gallo, G.R., Lamm, M.E., Experimental nephropathy induced by oral immunization. J Exp Med 157: 572.
Roccatello, D., Coppo, R., Piccoli, G., Cordonnier, D., Martina, G., Picciotto, G., Sena, L.M., Amoroso, A., 1985, Circulating Fc-receptor blocking factors in IgA nephropathies. Clin Nephrol 23: 159.
Nicholls, K., Kincaid-Smith, P., 1984, Defective in vivo Fc and C3b receptor function in IgA nephropathy. Am J Kidnev Dis 4: 128.
Roccatello, D., Picciotto, G., Coppo, R., Piccoli, G., Molino, A., Cacace, G., Amore, A., Sena, L.M., 1987, Delayed clearance of IgA immune complexes-like material in IgA nephropathy patients. (Abs) XXIVth Conoress of EDTA-European Renal Association, p 86.
Sato, M., Idema, T., Koshikawa, S., 1986, Experimental IgA nephropathy in mice. Lab Invest 54: 377.
Rifai, A., 1987, Experimental models for IgA-associated nephritis. Kidnev Int 31: 1.
Orlans, E., Peppard, J., Fry, J.F., Hinton, R.H., Mullock, B.M., 1979, Secretory component as the receptor for polymeric IgA on rat hepatocytes. J Exp Med 150: 1577.
Schena, F.P., Pastore, A., Sinico, R.A., Ladisa, N., Montinaro, V., Fornasieri, A., 1987, Studies on the mechanisms producing solubilization of immune precipitates in serum of patients with primary IgA nephropathy. Sem Neprol 7: 336.
Isaacs, K.L., Miller, F., 1982, Role of antigen size and charge in immune complex glomerulonephritis. I. Active induction of disease with dextran and its derivatives. Lab Invest 47: 198.
Tomino, Y., Sakai, H., Endoh, M., Cross reactivity of IgA antibodies between renal mesanglal areas and nuclei of tonsillar cells in patients with IgA nephropathy. Clin Exp Immunol 51: 605.
Coppo, R., Basolo, B., Rollino, C., Roccatello, D., Martina, G., Amore, A., Bongiorno, G., Piccoli, G., 1986, Mediterranean diet and primary IgA nephropathy. Clin Nephrol 26: 72.
Coppo, R., Roccatello, D., Amore, A., Quattrocchio, G., Molino, A., Maffei, S., Amoroso, A., Bajardi, P., Piccoli, G., Effects of gluten-free diet in primary IgA nephropathy (submitted for pubblication).
Coppo, R., Mazzucco, G., Martina, G., Sena, L.M., Roccatello, D., Amore, A., Novara, R., Bargoni, A., Ragni, R., Piccoli, G., 1987, Experimental IgA nephropathy induced by gluten-rich diet. (Abs.) Xth International Congress of Nephrology. London p. 320.
Kottigen, E., Volk, B., Kluga, F., Gerok, W., 1982, Gluten, a lectin with oligomannosyl specificity and the causative agent of gluten-sensitive enteropathy. Biochem Biophvs Res Commun 109: 168.
Scott, H., Fauza, O., EK, J., Brandtzaeg, P., 1984, Immune response patters in coeliac disease. Serum antibodies to dietary antigens measured by an enzyme-linked immunosorbent assay (ELISA). Clin Exp Immunol 57: 25.
Endo, Y., Hara, M., 1986, Glomerular IgA deposition in pulmonary diseases. Kidnev Int.29: 557.
Rifai, A., Chen, A., Imai, H., 1987, Complement activation in expeerimental nephropathy: an antigen-mediated process. Kidnev Int 32: 838.
Clarkson, A.R., Woodroffe, A.J., Aarons, I., Hiki, Y., Hale, G., 1987, IgA nephropathy. Am Rev Med 38: 157.
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© 1989 Plenum Press, New York
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Piccoli, G., Coppo, R., Roccatello, D., Amore, A. (1989). IgA Nephropathy in Systemic Diseases. In: Amerio, A., Coratelli, P., Campese, V.M., Massry, S.G. (eds) Drugs, Systemic Diseases, and the Kidney. Advances in Experimental Medicine and Biology, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8953-8_9
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DOI: https://doi.org/10.1007/978-1-4684-8953-8_9
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