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Drugs, Systemic Diseases, and the Kidney pp 371–376Cite as

Effects of Canrenone on Na+, K+ ATPase Activity, Arterial Pressure and Plasma Potassium Concentration in Uremic Hemodialyzed Patients

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 252))

Abstract

Canrenone is the main active metabolite1 of the diuretic and antihypertensive drugs spironolactone and canrenoate-K, and competes with aldosterone for a common cytosolic receptor in distal and collecting tubules of the nephron.2 In addition it has recently been demonstrated that canrenone in vitro may directly interfere with ouabain-sensitive Na+,K+ pump (Na+,K+ adenosine triphosphatase), acting as a partial agonist at the digitalis receptor site. 3,4 Moreover Garay et al.4 showed that canrenone is able to restimulate in vitro the Na+,K+ pump of human red blood cells (RBC) blocked by high concentrations of ouabain.

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Author information

Authors and Affiliations

  1. Institute of Nephrology, University of Torino, Torino, Italy

    F. Quarello, R. Boero, C. Guarena, C. Rosati, G. Beltrame, P. Colombo, I. M. Berto, M. Aimino, M. Formica & G. Piccoli

  2. Dialysis Unit, Nuova Astanteria Martini Hospital, Torino, Italy

    F. Quarello, R. Boero, C. Guarena, C. Rosati, G. Beltrame, P. Colombo, I. M. Berto, M. Aimino, M. Formica & G. Piccoli

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  1. F. Quarello
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  2. R. Boero
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  3. C. Guarena
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  4. C. Rosati
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  5. G. Beltrame
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  7. I. M. Berto
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  8. M. Aimino
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  10. G. Piccoli
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Editor information

Editors and Affiliations

  1. University of Bari, Bari, Italy

    Alberto Amerio  & Pasquale Coratelli  & 

  2. University of Southern California, Los Angeles, California, USA

    Vito M. Campese  & Shaul G. Massry  & 

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© 1989 Plenum Press, New York

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Quarello, F. et al. (1989). Effects of Canrenone on Na+, K+ ATPase Activity, Arterial Pressure and Plasma Potassium Concentration in Uremic Hemodialyzed Patients. In: Amerio, A., Coratelli, P., Campese, V.M., Massry, S.G. (eds) Drugs, Systemic Diseases, and the Kidney. Advances in Experimental Medicine and Biology, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8953-8_38

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  • DOI: https://doi.org/10.1007/978-1-4684-8953-8_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8955-2

  • Online ISBN: 978-1-4684-8953-8

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