Abstract
The atrial natriuretic peptide (ANP) released from the cardiocytes of mammalian atria has been implicated in the regulation of blood pressure and body fluid balance1,2. Previous studies have shown that this peptide can produce vasodepressor effect through a direct arterial vasodilation or reduced cardiac output and attenuation of endogenous vasoconstrictors2–5. Also, it can induce a striking natriuretic and diuretic effect by changing the renal hemodynamics and tubular functionl,2,6,7. The hypotensive and renal effects of ANP may be prominent in conditions with elevated activity of the renin-angiotensin system7–9.
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References
A.J. de Bold, H.B. Borenstein, A.T. Veress, and H. Sonnenberg, A rapid and potent natriuretic response to intravenous injection of atrial myocardial extracts in rats. Life Sci., 28:84 (1981).
B.J. Ballermann and B.M. Brenner, Role of atrial peptides in body fluid homeostasis, Circ. Res., 58:619 (1986).
R. Garcia, G. Thibault, M. Cantin and J. Genest, Effect of a purified atrial natriuretic factor on rat and rabbit vascular strips and vascular beds. Am. J. Physiol., 247:R34 (1984).
C.L. Huang, J. Lewicki, L.K. Johnson and M.G. Cogan, Renal mechanism of action of rat atrial natriuretic factor, J. Clin. Invest., 75:769 (1985).
H.D. Kleinert, T. Maack, S.A. Atlas, A. Januszewicz, J.E. Sealey and J. H. Laragh, Atrial natriuretic factor inhibits angiotensin-, norepinephrine and potassium-induced vascular contractility. Hypertension, 6(suppl I): 1143 (1984).
H. Sonnenberg, W.A. Cupples, A.J. de Bold and A.T. Veress, Intrarenal localization of the natriuretic effect of cardiac atrial extract. Can. J. Physiol. Pharmacol., 60:1149 (1982).
L.N. Peterson, C. de Rouffignac, H. Sonnenberg and D.Z. Levine, Thick ascending limb response to dDAVP and atrial natriuretic factor in vivo. Am. J. Physiol., 252:F374 (1987).
M. Volpe, G. Odell, H.D. Kleinert, et al.. Effect of atrial natriuretic factor on blood pressure, renin and aldosterone in Goldblatt hypertension. Hypertension, 7(suppl I):143 (1985).
B.S. Edwards, T.R. Schwab, R.S. Zimmerman, D.M. Heublein, N.S. Jiang and J.C. Burnett Jr., Cardiovascular, renal and endocrine response to atrial natriuretic peptide in angiotensin II mediated hypertension, Circ. Res., 59:663 (1986).
W.C. Huang, D.W. Ploth, P.D. Bell, J. Work and L.G. Navar, Bilateral renal function responses to converting enzyme inhibitor (SQ20881) in two-kidney, one clip Goldblatt hypertensive rats. Hypertension, 3:285 (1981).
W.G. Huang, D.W. Ploth and L.G. Navar, Angiotensin-mediated alterations in nephron function in Goldblatt hypertensive rats. Am. J. Physiol., 243:F553 (1982).
L.G. Nayar, W.C. Huang, K.D. Mitchell, C.A. Jackson and D.W. Ploth, Rerial rnechanisms of hypertension, in “Proceedings of the first congress of the Asian and Oceanian Physiological Societies”, C. Pholpramool and R. Sudsuang, ed., The Physiological Society, Thailand, pp. 253 (1987).
W.C. Huang and L.G. Navar, Effects of unclipping and converting enzyme inhibition on bilateral renal function in Goldblatt hypertensive rats. Kidney Int., 23:816 (1983).
W.C. Huang, Effects of verapamil alone and with Captopril on blood pressure and bilateral renal function in Goldblatt hypertensive rats, Clin. Sci., 70:453 (1986).
D.W. Ploth, N.R. Richard, W.C. Huang and L.G. Navar, Impaired renal blood flow and cortical pressure autoregulation in contralateral kidneys of Goldblatt hypertensive rats. Hypertension, 3:67 (1981).
B.M. Iversen, K.J. Heyeraas, I. Sekse, K.-J. Andersen and J. Ofstad, Autoregulation of renal blood flow in two-kidney, one-clip hypertensive rats. Am. J. Physiol., 251:F245 (1986).
W.R. Murphy, T.G. Coleman, T.L. Smith, and K.A. Stanek, Effects of graded renal arterial constriction on blood pressure, renal artery pressure, and plasma renin activity in Goldblatt hypertension. Hypertension, 6:68 (1984).
H. Thurston, R.F. Bing, E.S. Marks and J.D. Swales, Response of chronic renovascular hypertension to surgical correction or prolonged blockade of the renin -angiotensin system by two inhibitors in the rat, Clin. Sci., 58:15 (1980).
G.I. Russell, R.F. Bing, J.D. Swales and H. Thurston, Indomethacin or aprotinin infusion: Effect on reversal of chronic two-kidney, one-clip hypertension in the conscious rat, Clin. Sci., 62:361 (1982).
R. Dietz, G.J. Mast, A. Schomig, J.B. Luth and W. Rascher, Reversal of renal hypertension: Effects on renin, salt and water balance. Klin. Wochenschr., 56(suppl 1):23 (1978).
E.E. Muirhead, Antihypertensive functions of the kidney. Hypertension, 2:444 (1980).
R.F. Bing, G.I. Russell, J.D. Swales, H. Thurston and A. Fletcher, Chemical renal medullectomy: Effect upon reversal of two-kidney, one- clip hypertension in the rat, Clin. Sci., 61:335s (1981).
G. Gothberg, S. Lundin and B. Folkow, Acute vasodepressor effect in normotensive rats following extracorporal perfusion of the declipped kidney of two-kidney, one-clip hypertensive rats. Hypertension, 4 (suppl II): II-101 (1982).
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© 1989 Plenum Press, New York
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Huang, WC., Wu, JN. (1989). Characterization of Bilateral Renal Response to Atrial Natriuretic Peptide in 2-Kidney, 1 Clip Hypertensive Rats. In: Amerio, A., Coratelli, P., Campese, V.M., Massry, S.G. (eds) Drugs, Systemic Diseases, and the Kidney. Advances in Experimental Medicine and Biology, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8953-8_35
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DOI: https://doi.org/10.1007/978-1-4684-8953-8_35
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