Skip to main content

Nephrotoxicity of Fumaric Acid Monoethylester (FA ME)

  • Chapter
Drugs, Systemic Diseases, and the Kidney

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 252))

Abstract

Fumaric acid monoethylester (FA ME) is used as a therapeutic agent against psoriasis. As there exists some clinical evidence for nephro — toxicity (2,9) the present investigations were performed.

This work was Supported by “Deutscher Psoriasisbund”, Hamburg FRG.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bradford M.M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal.Biochem. 72, 248–254, 1976.

    Article  PubMed  CAS  Google Scholar 

  2. Dubiel W., Happle R.: Behandlungsversuch mit Fumarsäuremonoäthyl – ester bei Psoriasis vulgaris. Z.Hautkrankh. 47, 545–550, 1972.

    CAS  Google Scholar 

  3. Hagedorn M., Kalkoff K.W., Kiefer G., Baron D., Hug J., Petres J.: Fumarsäuremonoäthylester: Wirkung auf DNA Synthese und erste tier – experimentelle Befunde. Arch.Derm.Res. 254, 67–73, 1975.

    Article  CAS  Google Scholar 

  4. Hohenegger M., Vermes M., Esposito R., Giordano C.: Effect of some uremic toxins on oxygen consumption of rats in vivo and in vitro. Nephron 48, 154–158, 1988.

    Article  PubMed  CAS  Google Scholar 

  5. Holzer F., Hohenegger M.: Sodium and potassium adaptation in the conscious rat. Pharmacology l0, 76–81, 1973.

    Article  Google Scholar 

  6. Hörl W., Echsel H., Hohenegger M.: The key role of sex dependency on kidney citrate metabolism in the rat. Res.Exp.Med. 185, 69–75, 1985.

    Article  Google Scholar 

  7. Korsatko W., Sadjak A., Gall P., Supanz S.: Entwicklung kombinierter Inulin – PAH Retardimplantationstabletten zur Bestimmung der Clearance an wachen Ratten. Die Pharmazie 43, 324–327, 1987.

    Google Scholar 

  8. Om P., Hohenegger M.: Energy metabolism in acute uremic rats. Nephron 25, 249–253, 1980.

    Article  PubMed  CAS  Google Scholar 

  9. Raab W.: Psoriasis Behandlung mit Fumarsäure und Fumarsäureestem. Z.Hautkrankh. 59, 671–679, 1984.

    CAS  Google Scholar 

  10. Renschier D.: Die enzymatischen Methoden zur Bestimmung von Inulin. Klin.Wschr. 41, 615–618, 1961.

    Article  Google Scholar 

  11. Ruiz-Guinazu A., Pehling G., Rumrich G., Ullrich K.J.: Glucose- un Milchsäurekonzentration an der Spitze des vasculären Gegenstrom systems im Nierenmark. Pflügers Arch.Ges.Physiol. 274, 311–317, 1961.

    Article  CAS  Google Scholar 

  12. Sadjak A., Egger G., Kink E., Korsatko W.: Functional and morphological changes in the rat kidney after long term adrenaline application. Exp.Pathol. 25, 27–33, 1984.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Hohenegger, M., Vermes, M., Sadjak, A., Egger, G., Supanz, S., Erhart, U. (1989). Nephrotoxicity of Fumaric Acid Monoethylester (FA ME). In: Amerio, A., Coratelli, P., Campese, V.M., Massry, S.G. (eds) Drugs, Systemic Diseases, and the Kidney. Advances in Experimental Medicine and Biology, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8953-8_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8953-8_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8955-2

  • Online ISBN: 978-1-4684-8953-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics