Skip to main content

Aminoglycoside Nephrotoxicity: Mechanism and Prevention

  • Chapter
Drugs, Systemic Diseases, and the Kidney

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 252))

Abstract

Nephrotoxicity limits the clinical utility of aminoglycosides (Lietman, 1985). Therefore, the identification of factors associated with a greater incidence of renal damage is critical. These factors can be classified in those related to the drug and its administration and those related to the clinical condition of the patient (Table 1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Blaser, J., Stone, B.B. and Zinner, S.H. 1985. Efficacy of intermittent versus continuous administration of netilmicin in a two-compartment model. Antimicrob. Agents Chemother. 27: 343–349.

    Article  PubMed  CAS  Google Scholar 

  • Collier, V.V., Lietman, P.S. and Mitch, W.E. 1979. Evidence of luminal uptake of gentamicin in the perfused rat kidney. J. Pharmacol. Exp. Ther. 210: 247–251.

    PubMed  CAS  Google Scholar 

  • Craig, W.A. and Vogelman, B. 1987. The postantibiotic effect. Ann. Intern. Med. 106: 900–902.

    PubMed  CAS  Google Scholar 

  • De Broe, M.E., Paulus, G.J., Verpooten, G.A., Giuliano, R.A., Roels, F. and Tulkens, P.M. 1983. In “Proceedings of the 13th. International Congress of Chemotherapy: Side effects of antibiotics”. August 28-September 2, 1983, SE 8.4/1, part 86. Spitzy, K.H. and Karrer, K, eds., 86/11–86/23.

    Google Scholar 

  • De Broe, M.E., Paulus, G.J., Verpooten, G.A., Roels, F., Buyssens, N., Wedeen, R.P. 1984. Early effects of gentamicin, tobramycin, and amikacin on the human kidney. Kidney Int. 25: 643–652.

    Article  PubMed  Google Scholar 

  • De Broe, M.E. 1985. Prevention of aminoglycoside nephrotoxicity. In: Proceedings of the European Dialysis and Transplantation Association- European Renal Association. Davison, A.M., and Guillow, P.J., eds., Bailliere Tindall Pub., London, Vol 22: 959–973.

    Google Scholar 

  • Fabre, J., Rudhart, M., Blanchard, P. and Regamey, C. 1976. Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats. Kidney Int. 10: 444–449.

    Article  PubMed  CAS  Google Scholar 

  • Giuliano, R.A., Paulus, G.J., Verpooten, G.A., Pattyn, V.M., Pollet, D.E., Nouwen, E.J., Laurent, G., Carlier, M.B., Maldague, P., Tulkens, P.M. and De Broe, M.E. 1904. Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats. Kidney Int 26: 838–847.

    Article  Google Scholar 

  • Giuliano, R.A., Verpooten, G.A., Verbist, L., Wedeen, R.P. and De Broe M.E. 1986 a. In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats. J. Pharmacol. Exp. Ther. 236: 1470–475.

    Google Scholar 

  • Giuliano, R.A., Verpooten, G.A. and De Broe, M.E. 1986 b. The effect of dosing strategy on kidney cortical accumulation of aminoglycosides. Am. J. Kidney Dis. 8: 297–303.

    PubMed  CAS  Google Scholar 

  • Houghton, D.C., Hartnett, M.L., Campbell-Boswell, M., Porter, G. and Bennett, W. 1976. A light and electron microscopic analysis of gentamicin nephrotoxicity in rats. Am. J. Pathol. 82: 589–612.

    PubMed  CAS  Google Scholar 

  • Josepovitz, C., Pastoriza-Munoz, E., Timmerman, D., Scott, M., Feldman, S. and Kaloyanides, G.J. 1982. Inhibition of gentamicin uptake in rat renal cortex in vivo by aminoglycosides and organic polycations. J. Pharm. Exp. Ther. 233: 314–321.

    Google Scholar 

  • Just, M. and Habermann, E. 1977. The renal handling of polybasic drugs. 2. In vitro studies with brush border and lysosomal preparations. Naunyn-Schmiedeberg’s Arch. Pharmacol. 300: 67–76.

    CAS  Google Scholar 

  • Kaloyanides, G.J. and Pastoriza-Munoz, E. 1980. Aminoglycoside nephrotoxicity. Kidney Int. 18: 571–582.

    Article  PubMed  CAS  Google Scholar 

  • Kleinknecht, D., Landais, P. and Goldfard, B. 1985 Drug-associated acute renal failure. A prospective multicenter report. In: Proceedings of the European Dialysis and Transplantation Association – European Renal Association. Davison, A.M. and Guillou, P.J. eds. Bailliere Tindall Pub. London 22: 1002–1007.

    Google Scholar 

  • Kosek, J.C., Mazz, R.I. and Cousins, M.J. 1974. Nephrotoxicity of gentamicin. Lab. Invest. 30: 48–57.

    PubMed  CAS  Google Scholar 

  • Laurent, G., Carlier, M.B., Rollman, B., Van Hoof, F. and Tulkens, P.M. 1982. Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin. Biochem. Pharmacol. 31: 3861–387O.

    Article  PubMed  CAS  Google Scholar 

  • Lietman, P.S. 1985. Aminoglycosides and spectinomycin: aminocyclitols. In: Principles and practice of infectious diseases. 2nd Edition. Part I: Basic principles in the diagnosis and management of infectious diseases. Mandel, G.L., Douglas Jr, R.G. and Bennett, J.E., eds. John Wiley and Sons, New York, Chichester: 192–206.

    Google Scholar 

  • Moore, R.D., Smith, C.R., Lipsky, J.J., Mellitis E.D., and Lietman, P.S. 1981. Risk factors for nephrotoxicity in patients treated with aminoglycosides. Ann. Intern. Med. 100: 352–357.

    Google Scholar 

  • Pattyn, V.M., Verpooten, G.A., Giuliano, R.A., Zheng, F.L. and De Broe, M.D. 1987. Effect of hyperfiltration, proteinuria and diabetes mellitus on the uptake kinetics of gentamicin in the kidney cortex of rats. J. Pharmacol. Exp. Ther. 244: 694–698.

    Google Scholar 

  • Powel, S.H., Thompson, W.L., Luthe, M.A., Stern, R.C., Grossniklaus, D.A., Bloxham, D.D., Groden, D.L., Jacobs, M.R., Discenna, A.O., Cash, H.A. and Klinger, J.D. 1983. Once daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin and tobramycin. J. Infect. Dis. 147: 918–932.

    Article  Google Scholar 

  • Reiner, N.E., Bloxham, D.D., and Thompson, W.L. 1978. Nephrotoxicity of gentamicin and tobramycin given once daily or continuously in dogs. J. Antimicrob. Chemother. 4 (Suppl.A): 85–101.

    Article  PubMed  CAS  Google Scholar 

  • Reymann, M.T., Bradac, J.A. and Cobbs, C.G. 1979. Correlation of aminoglycoside dosages with serum concentrations during therapy of serious gram negative bacillary disease. Antimicrob. Agents Chemother. l6: 353–365.

    Article  Google Scholar 

  • Silverblatt, F. and Kuehn, C. 1979. Autoradiography of gentamicin uptake by the rat proximal tubular cell. Kidney Int. 15: 335–3-5.

    Article  PubMed  CAS  Google Scholar 

  • Smith, C.R., Maxwell, R.R. and Edwards, C.Q. 1978. Nephrotoxicity induced by gentamicin and amikacin. John Hopkins Med. J. 142: 85–90.

    CAS  Google Scholar 

  • Tulkens, P.M., De Broe, M.E., Maldague, P. and Heuson-Stiennon, J.A. 1984. Lysosomal alterations in aminoglycoside-induced acute renal failure. In: Acute Renal Failure: correlations between morphology and function. Solez, K., and Whelton, A., eds. Marcel Dekker, Pub., New York: 299–327.

    Google Scholar 

  • Verpooten, G.A., Giuliano, R.A., Pattyn, V.M., SchärpĂ©, S.L. and De Broe, M.E. 1986. Renal cortical uptake kinetics of gentamicin in rats with impaired renal fimction. Am. J. Kidney Dis. 8: 304–307.

    PubMed  CAS  Google Scholar 

  • Verpooten, G.A., Giuliano, R.A., Verbist, L., Eestermans, G. and De Broe, M.E. 1988. A once-daily dosage schedule decreases the acciomulation of gentamicin and netilmicin in the renal cortex of humans. Submitted.

    Google Scholar 

  • Wedeen, R.P., Batuman, V., Cheeks, E.M., Marquet, E. and Sobel, H. 1983.Transport of gentamicin in rat proximal tubule. Lab. Invest. 48:212–223.

    PubMed  CAS  Google Scholar 

  • Whelton, A. 1985 Therapeutic initiative for avoidance of aminoglycoside toxicity. J. Clin. Pharmacol. 25: 67–81.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

De Broe, M.E., Giuliano, R.A., Verpooten, G.A. (1989). Aminoglycoside Nephrotoxicity: Mechanism and Prevention. In: Amerio, A., Coratelli, P., Campese, V.M., Massry, S.G. (eds) Drugs, Systemic Diseases, and the Kidney. Advances in Experimental Medicine and Biology, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8953-8_22

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8953-8_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8955-2

  • Online ISBN: 978-1-4684-8953-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics