Abstract
The Authors report the clinical features of cystine nephrolithiasis in 57 patients with cystinuria observed from 1972 to 1980. The disease affects both sexes with equal frequency and severity. Symptom usually begin early, mostly between 15 and 20 years, but may develop at any age. Treatment consists of the administration of adequate oral fluids to obtain a copious urine volume, of oral alkali and of α-mercaptopropionylglycine. Successful results, from litholytic and from preventive medical treatment, were obtained in a high percentage of cases.
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References
Bartter, F.C., Lötz, M. and Thier, S.O.: Cystinuria. Ann, Int. Med. 62: 796–822, (1965).
Caldwell, R.J., Townsend, J.I. and Smith, M.J.V.: Genetics of cystinuria in an inbred population. J. Urol. 119: 531–533, (1978).
Dahlberg, P.J., Van der Berg, C.J., Kurtz, S.B., Wilson, D.M. and Smith, L.H.: Clinical features and management of cystinuria. Mayo Clinic. Proc. 52: 533–542, (1977).
Dent, C.E. and Senior, B.: Studies in the treatment of cystinuria. Brit. J. Urol. 27: 317–332, (1955).
Kallistratos, G., Burchardt, P. and Freerksent, P.: Recent advances in the diagnosis and treatment of L-cystine stone disease. Folia Bioch. Biol. Graeca 15: 21–23, (1978).
King, J.S. Jr.: Treatment of cystinuria with öC-mercaptopropionylglycine. Proc. Soc. Exp. Biol. Med, 199: 927–932, (1969),
Kinoschita, K., Yachiku, S., Takeuki, N., Kotake, T., and Sonoda, T.: Treatment of cystinuria with (X-mercaptopropio- nylglycine. Proc. 2nd int. Symp. on Thiola, pp. 50–54 Santen, Osaka, (1972).
Hautmann, R., Terhost, B., Stuhlsatz, H.W. and Lutzeyer, W.: Mercaptopropionylglycine: a progress in cystine stone therapy. J. Urol. 117: 628–630, (1977).
Lötz, M., Potts, J.T. Jr. and Holland, J.M.: D-penicillamine therapy in cystinuria. J. Urol, 95: 257–263, (1966).
Miano, L.: Cistinuria e litiasi cistinica. Progr, Med. 28: 285–287, (1972).
Miano, L., Gallucci, M. and Petta, S.: Results of medical treatment of cystine lithiasis. Eur. Urol. 5: 265–272, (1979).
Remieen, A., Kallistratos, G. and Burchardt, P.: Treatment of cystinuria with Thiola (α.-mercaptopropionylglycine). Eur. Urol. 1: 227–230, (1975).
Rosenberg, L.E., Downing, S. and Durant, J.L.: Cystinuria: biochemical evidence for three genetically distinct diseases. J. Clin. Invest. 45: 365–371, (1966).
Silbernagl, S.: Renal handling of aminoacids: recent results of tubular microperfusion. Clin. Nephrol. 5: 1–8, (1976).
Terhorst, B. and Stuhlsatz, H.W.: Cysteine Therapie mit Mercaptopropionylglycine (MPG). Urologe 14: 190–193, (1975).
Thier, S.O. and Segal, S.: Cystinuria in “The metabolic basis of inherited disease” edited by Stanbury J.B., Wyngaarden J.B., Fredrickson D.S., pp. 1504–1519 Mc Graw-Hill Book Comp., New York, (1972).
Zechner, O., Latal, D., Grundig, E. and Muller, M.: Klinische Aspekte der Cystinuria und ihre Behandlung mit Thiola. Wien. Klin. Wschr. 88: 101–105, (1976).
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© 1981 Plenum Press, New York
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Miano, L., Antonozzi, I., Gallucci, M., Morano, S., Petta, S. (1981). Clinical Features and Management of Cystine Nephrolithiasis. In: Pavone-Macaluso, M., Smith, P.H., Vercellone, A., Maiorca, R., Rotolo, U. (eds) Advances in Nephrourology. Ettore Majorana International Science Series, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8944-6_28
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DOI: https://doi.org/10.1007/978-1-4684-8944-6_28
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