Skip to main content

Clinical Features and Management of Cystine Nephrolithiasis

  • Chapter
Advances in Nephrourology

Part of the book series: Ettore Majorana International Science Series ((PHYSC,volume 9))

Abstract

The Authors report the clinical features of cystine nephrolithiasis in 57 patients with cystinuria observed from 1972 to 1980. The disease affects both sexes with equal frequency and severity. Symptom usually begin early, mostly between 15 and 20 years, but may develop at any age. Treatment consists of the administration of adequate oral fluids to obtain a copious urine volume, of oral alkali and of α-mercaptopropionylglycine. Successful results, from litholytic and from preventive medical treatment, were obtained in a high percentage of cases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bartter, F.C., Lötz, M. and Thier, S.O.: Cystinuria. Ann, Int. Med. 62: 796–822, (1965).

    Google Scholar 

  2. Caldwell, R.J., Townsend, J.I. and Smith, M.J.V.: Genetics of cystinuria in an inbred population. J. Urol. 119: 531–533, (1978).

    Google Scholar 

  3. Dahlberg, P.J., Van der Berg, C.J., Kurtz, S.B., Wilson, D.M. and Smith, L.H.: Clinical features and management of cystinuria. Mayo Clinic. Proc. 52: 533–542, (1977).

    Google Scholar 

  4. Dent, C.E. and Senior, B.: Studies in the treatment of cystinuria. Brit. J. Urol. 27: 317–332, (1955).

    Article  Google Scholar 

  5. Kallistratos, G., Burchardt, P. and Freerksent, P.: Recent advances in the diagnosis and treatment of L-cystine stone disease. Folia Bioch. Biol. Graeca 15: 21–23, (1978).

    Google Scholar 

  6. King, J.S. Jr.: Treatment of cystinuria with öC-mercaptopropionylglycine. Proc. Soc. Exp. Biol. Med, 199: 927–932, (1969),

    Google Scholar 

  7. Kinoschita, K., Yachiku, S., Takeuki, N., Kotake, T., and Sonoda, T.: Treatment of cystinuria with (X-mercaptopropio- nylglycine. Proc. 2nd int. Symp. on Thiola, pp. 50–54 Santen, Osaka, (1972).

    Google Scholar 

  8. Hautmann, R., Terhost, B., Stuhlsatz, H.W. and Lutzeyer, W.: Mercaptopropionylglycine: a progress in cystine stone therapy. J. Urol. 117: 628–630, (1977).

    Google Scholar 

  9. Lötz, M., Potts, J.T. Jr. and Holland, J.M.: D-penicillamine therapy in cystinuria. J. Urol, 95: 257–263, (1966).

    Google Scholar 

  10. Miano, L.: Cistinuria e litiasi cistinica. Progr, Med. 28: 285–287, (1972).

    Google Scholar 

  11. Miano, L., Gallucci, M. and Petta, S.: Results of medical treatment of cystine lithiasis. Eur. Urol. 5: 265–272, (1979).

    Google Scholar 

  12. Remieen, A., Kallistratos, G. and Burchardt, P.: Treatment of cystinuria with Thiola (α.-mercaptopropionylglycine). Eur. Urol. 1: 227–230, (1975).

    Google Scholar 

  13. Rosenberg, L.E., Downing, S. and Durant, J.L.: Cystinuria: biochemical evidence for three genetically distinct diseases. J. Clin. Invest. 45: 365–371, (1966).

    Article  Google Scholar 

  14. Silbernagl, S.: Renal handling of aminoacids: recent results of tubular microperfusion. Clin. Nephrol. 5: 1–8, (1976).

    Google Scholar 

  15. Terhorst, B. and Stuhlsatz, H.W.: Cysteine Therapie mit Mercaptopropionylglycine (MPG). Urologe 14: 190–193, (1975).

    Google Scholar 

  16. Thier, S.O. and Segal, S.: Cystinuria in “The metabolic basis of inherited disease” edited by Stanbury J.B., Wyngaarden J.B., Fredrickson D.S., pp. 1504–1519 Mc Graw-Hill Book Comp., New York, (1972).

    Google Scholar 

  17. Zechner, O., Latal, D., Grundig, E. and Muller, M.: Klinische Aspekte der Cystinuria und ihre Behandlung mit Thiola. Wien. Klin. Wschr. 88: 101–105, (1976).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Press, New York

About this chapter

Cite this chapter

Miano, L., Antonozzi, I., Gallucci, M., Morano, S., Petta, S. (1981). Clinical Features and Management of Cystine Nephrolithiasis. In: Pavone-Macaluso, M., Smith, P.H., Vercellone, A., Maiorca, R., Rotolo, U. (eds) Advances in Nephrourology. Ettore Majorana International Science Series, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8944-6_28

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8944-6_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8946-0

  • Online ISBN: 978-1-4684-8944-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics