Abstract
In Italy about 25% of all renal calculi are composed of uric acid and/or urates. This percentage includes also the cases with mixed stones (uric acid + calcium oxalate and/or apatite). In our series uric acid nephrolithiasis was idiopathic in 60% of the cases, while in 40% it was associated with abnormal purine metabolism. Our extended observation confirms our previous therapeutic experience and is similar to that of other investigators in this field. Simple dietary measures, adequate hydration and control of urine hyperacidity were considered satisfactory therapy. This was proved by the decrease in frequency of new stone formation, and by complete or partial stone dissolution, thereby decreasing the number of surgical procedures. Allopurinol is the drug of choice in recurrent uric acid lithiasis associated with hyperuricosuric states.
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References
Atsmon, A., De Vries, A. and Frank, M.: Uric acid lithiasis. Elsevier, Amsterdam, 1963.
Cottet, J.: Le syndrome biochimique des lithiases urinaires, in “Handbuch der Urologie.Die Steinerkrankungen” Springer Verlag., Berlin, vol. X, 1961.
De Vries, A., Frank, M., Weinberger, A. and Oliver; Treatment of uric acid lithiasis. Observation on 658 patients. In: “Urinary calculi. Recent advances in aetiology, stone structure and treatment” edited by Cifuentes Delatte L., Rapado A., Hodgkinson A., pp. 105–111 Karger, Basel, 1973.
Eisenberg, H., Connor, T.B. and Howard, J.E.: A useful agent for oral alkali therapy. J. Clin, Endocr. 15: 503–505, (1955).
Frank, M., Lazebnik, J. and De Vries, A.: Uric acid lithiasis: a study of six hundred and twenty-two patients. Urol. Int. 25; 32–46, (1970).
Freiha, F.S. and Hemady, K.: Dissolution of uric acid stones, alternative to surgery. Urology 8: 334–337, (1976),
Godfrey, R.G. and Rankin, T.J.: Uric acid renal lithiasis. Management by allopurinol, J. Urol, 101: 643–647, (1969).
Gordon, M.R., Carrion, H.M. and Politano, V.A.: Dissolution of uric acid calculi with Tham irrigation. Urology 12: 393–397, (1978).
Gutman, A.B. and Yu, T.F.: Uric acid nephrolithiasis, Amer. J. Med. 45: 756–779, (1968).
Gutman, A.B.: Views on the pathogenesis and management of primary gout. J. Bone J. Surg. 54A: 357, (1972).
Levinson, D.J. and Sorensen, L.B.: Uric acid stone. In: F.L. Coe “Nephrolithiasis. Pathogenesis and treatment” (Year Book Med. Publ., Chicago, 1978),
Micali, F. and Miano, C.: Considerazioni sul ruolo del pH uri- nario nella genesi della urolitiasi. Chir. Urol. 8: 293–305, (1966).
Miano, L., Arachi, N. and Cammarano, R.: La litiasi urica oggi: problemi di diagnosi e terapia. Chir. Urol. 9: 14–20, (1967).
Petritsch, P.H.: Uric acid calculi. Results of conservative treatment. Urology 10: 536–538, (1977).
Pyrah, L.N.: Renal calculus. Springer Verlag, Berlin, 1979.
Terhorst, B. and Melchior, H,: Rezidivprophylaxe bei Urolithiasis. Z. Urol. 62: 761, (1969).
Uhlir, K. The peroral dissolution of renal calculi. J. Urol. 104: 239–247 (1970).
Yu, T.F.: Nephrolithiasis in patients with gout. Postgr. Med. 63: 164–170, (1978).
Zollner, N. and Griebsch, A.: Diet and gout. Adv. Exp. Med. Biol. 41B: 433–442, (1977).
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© 1981 Plenum Press, New York
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Miano, L., Petta, S., Gallucci, M., Goldoni, S. (1981). Uric Acid Nephrolithiasis — Prevalence, Pathogenesis and Results of Conservative Treatment. In: Pavone-Macaluso, M., Smith, P.H., Vercellone, A., Maiorca, R., Rotolo, U. (eds) Advances in Nephrourology. Ettore Majorana International Science Series, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8944-6_27
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DOI: https://doi.org/10.1007/978-1-4684-8944-6_27
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