Abstract
Hypoxia is a complication which frequently occurs in human infants who have experienced perinatal stress. Although cardiovascular (CV) responses to hypoxia are well documented in both the fetus and adult, there is limited information about the postnatal maturation of regional circulatory responses to hypoxia, still less on the sympathetic rhythm generating systems (SRGS), as monitored by recordings of spontaneous efferent sympathetic (SAMP) activity. On the other hand, the effects of hypoxia on the developing respiratory rhythm generator (RRG) have been well documented in many species (cf. Gootman et al., 1989; Steele, 1986). In our previous studies, maturation- related responses to other stresses, i.e., hemorrhage and hypercapnia, were observed in swine (Buckley et al., 1984; Gootman et al., 1985; Reddy et al., 1974). This animal model is less mature at birth than lambs and guinea pigs, and more mature at birth than puppies, rats, and kittens (N.M. Buckley, 1983, 1986; Gootman, 1983). This paper summarizes our studies on the effects of two degrees of hypoxia on four different regional circulations and on efferent SYMP and phrenic activity in swine from birth to 2 months of age.
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© 1990 Plenum Press, New York
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Gootman, P.M. et al. (1990). Effects of Hypoxia in Developing Swine. In: Acker, H., Trzebski, A., O’Regan, R.G. (eds) Chemoreceptors and Chemoreceptor Reflexes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8938-5_23
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DOI: https://doi.org/10.1007/978-1-4684-8938-5_23
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