Abstract
Perfusion of individual organs of the body in the isolated state is a powerful tool for the study of their integrated function. This approach has provided, for example, a wealth of knowledge on the relationship between metabolism and function in several tissues, including heart, liver, kidney, and skeletal muscle. The carotid body, however, has proven unreliable as an in vitro perfused model.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Acker, H., 1989, PO2 chemoreception in arterial chemoreceptors, Ann. Rev. Physiol., 51:835.
Eyzaguirre, C., and Koyano, H., 1965, Effects of hypoxia, hypercapnia, and pH on the chemoreceptor activity of the carotid body in vitro, J. Physiol. (Lond.), 178:385.
Fidone, S. J., and Gonzalez, C., 1986, Initiation and control of chemoreceptor activity in the carotid body, in: “Handbook of Physiology. The Respiratory System. Control of Breathing,” A. P. Fishman, ed.. Am. Physiological Society, Bethesda.
Grinstein, S., Cojen, S., and Rothstein, A., 1984, Cytoplasmic pH regulation in thymic lymphocytes by an Amiloride-sensitive Na+/H+ antiport, J. Gen. Physiol., 83:341.
Hanson, M. A., Nye, P. C. G., and Torrance, R. W., 1981, The exodus of an extracellular bicarbonate theory of chemoreception and the genesis of an intracellular one, in: “Arterial Chemoreceptors,” Belmonte, C., Pallet, D. J., Acker, H., and Fidone, S., eds., Leicester University Press.
Lahiri, S., 1981, Chemical modification of carotid body chemoreception by sulfhydryls. Science, 212:1065.
Lahiri, S., and DeLaney, R. G., 1975, Stimulus interaction in the responses of carotid body chemoreceptor single afferent fibers, Respir. Physiol., 24:249.
Mills, E., and Jöbsis, F., 1972, Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension, J. Neuro. Physiol., 5:405.
Moolenaar, W. H., Tsien, R. Y., van der Saag, P. T., and de Laat, S. W., 1983, Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts. Nature, 304:645.
Mulligan, E., Lahiri, S., and Storey, B. T., 1981, Carotid body O2 chemoreception and mitochondrial oxidative phosphorylation, J. Appl. Physiol., 51:438.
Nuutinen, E. M., Nishiki, K., Erecinska, M., and Wilson, D. F., 1982, Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow. Am. J. Physiol., 243:H169.
Paradiso, A. M., Tsien, R. Y., and Machen, T. E., 1984, Na+/H+ exchange in gastric glands as measured with a cytoplasmic-trapped, fluorescent pH indicator, Proc. Natl. Acad. Sci., 81:7436.
Rumsey, W. L., Vanderkooi, J. M., and Wilson, D. F., 1988, Imaging of phosphorescence: A novel method for measuring oxygen distribution in perfused tissue. Science, 241:1649.
Shirahata, M., Andronikou, S., and Lahiri, S., 1987, Differential effects of oligomycin on carotid chemoreceptor responses to O2 and CO2 in the cat, J. Appl. Physiol., 63:2084.
Torrance, R. W., 1977, Manipulation of bicarbonate in the carotid body, in: “Chemoreception in the Carotid Body,” Acker, H., Fidone, S., Pallot, D., Eyzaguirre, C., Lübbers, D. W., and Torrance, R. W., eds., Springer-Verlag, New York.
Vanderkooi, J., and Wilson, D. F., 1986, A new method for measuring oxygen in biological systems. Adv. Exp. Med. Biol., 200:189.
Wilson, D. F., Rumsey, W. L., Green, T. J., and Vanderkooi, J. M., 1988, The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration, J. Biol. Chem., 263:2712.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Rumsey, W.L., Iturriaga, R., Wilson, D.F., Lahiri, S., Spergel, D. (1990). Phosphorescence and Fluorescence Imaging: New Tools for the Study of Carotid Body Function. In: Acker, H., Trzebski, A., O’Regan, R.G. (eds) Chemoreceptors and Chemoreceptor Reflexes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8938-5_10
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8938-5_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8940-8
Online ISBN: 978-1-4684-8938-5
eBook Packages: Springer Book Archive