Role of Hemodynamic Factors in Atherogenesis

  • Takeshi Karino
  • Toshihisa Asakura
  • Shoji Mabuchi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 242)


Clinical and postmortem studies indicate that atherosclerotic lesions on the vessel wall develop not randomly, and not everywhere in the circulation, but at particular localized sites in the arterial tree such as bifurcations, T-junctions, and curved segments of arteries where the blood flow is disturbed and formation of eddies is likely to occur. Thus, to elucidate the possible connection between blood flow and the localized genesis and development of atherosclerosis, a considerable amount of work has been carried out in recent years.1,2 Theoretically, through the development of computational techniques, it has now become possible to simulate the blood flow through various channels, but the analysis is still limited to only those vessels having oversimplified geometries. Experimentally, due to the difficulties in visualizing the detailed flow patterns in vivo, most of the flow studies have been conducted in vitro using various models of arteries3–5 and arterial molds.6–8 However, even with the high quality casting and molding techniques available today, it is still not easy to precisely duplicate the complex geometry of the vessel lumen encountered in various regions of the circulation.


Wall Shear Stress Left Anterior Descend Recirculation Zone Pulsatile Flow Curve Segment 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Takeshi Karino
    • 1
  • Toshihisa Asakura
    • 1
  • Shoji Mabuchi
    • 1
  1. 1.McGill University Medical ClinicMontreal General HospitalMontrealCanada

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