Matrix Control of Tumor Angiogenesis

  • W. Reilly
  • B. R. McAuslan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 242)


Tumor angiogenesis is the process through which certain tumors stimulate the growth of the microvascular network in the surrounding tissue. This capillary network is remarkable in that the growth is directed towards the tumor which becomes vascularized. An important fundamental question is, what is the nature of the molecular controls responsible for the directed vascularization? As cell migration is the salient feature in neovascularization the question thus becomes, what are the molecular events that control cell migration during neovascularization? A wide variety of compounds have been shown to be inducers of angiogenesis or neovascularization in vivo. These include both tumor or tissue derived factors as well as a number of chemical factors.1,2,3,4,5,6 All of these, with the exception fo angiogenin, have been shown to also induce endothelial cell migration.


Migration Rate Angiogenic Factor Endothelial Cell Migration Coated Coverslip Tumor Angiogenic Factor 
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  1. 1.
    B.R. McAuslan, W. Reilly, G.N. Hannan and G.A. Gole, Angiogenic factors and their assay: activity of formyl methionyl leucyl phenylalanine, adenosine diphosphate, heparin, copper and bovine endothelium stimulating factor, Microvasc. Res. 26:323 (1983).PubMedCrossRefGoogle Scholar
  2. 2.
    J. Folkman, E. Merler, C. Abernathy and G. Williams, Isolation of a tumor factor responsible for angiogenesis, J. Exp. Med. 133:275 (1971).PubMedCrossRefGoogle Scholar
  3. 3.
    R.D. Kissun, C.R. Hill, A. Garner, P. Phillips, S. Kumar and J.B. Weiss, A low molecular weight angiogenic factor in cat retina, Brit. J. Ophthal. 66:165 (1982).PubMedCrossRefGoogle Scholar
  4. 4.
    M.J. Banda, D.R. Knighton, T.K. Hunt and Z. Webb, Isolation of a nonmitogenic angiogenesis factor from wound fluid, Proc. Natl. Acad. Sci. USA 79:7773 (1982).PubMedCrossRefGoogle Scholar
  5. 5.
    M. Ziehe, J. Jones and P.M. Gullino, Role of prostaglandin El and copper in angiogenesis, J. Natl. Cancer Inst. 69:475 (1982).Google Scholar
  6. 6.
    J.W. Fett, D.J. Strydom, B.R. Lobb, E.M. Alderman, J.L. Bethune, J.F. Riordan and B.L. Vallee, Isolation and characterization of angiogenin and angiogenic protein from human carcinoma cells. Biochemistry 24:5480 (1985).PubMedCrossRefGoogle Scholar
  7. 7.
    D.M. Form, B.M. Pratt and J.A. Madri, Endothelial cell proliferation during angiogenesis. Lab. Invest. 55:521 (1986).PubMedGoogle Scholar
  8. 8.
    K. Nabeshima, H. Kataoka and M. Koono, Enhanced migration of tumor cells in response to collagendegradation products and tumor cell collagenolytic activity. Invasion and Metastasisy 6:270 (1986).Google Scholar
  9. 9.
    B.R. McAuslan and G.A. Gole, Cellular and molecular mechanisms in angiogenesis. Trans. Ophthal. Soc. UK 100:354 (1980).PubMedGoogle Scholar
  10. 10.
    D.B. Rifkin, J.L. Gross, D. Moscatelli and E. Jaffe, Proteases, angiogenesis and invasion, Symp. Fundam. Cancer Res. 36:187 (1983).PubMedGoogle Scholar
  11. 11.
    J.H. Greenberg, S. Seppa, H. Seppa and A.T. Hewitt, Role of collagen and fibronectin in neural crest cell adhesion and migration, Devel. Biol. 87:259 (1981).CrossRefGoogle Scholar
  12. 12.
    I.M. Herman, Extracellular matrix-cytoskeletal interactions in vascular cells. Tissue and Cell 19:1 (1987).PubMedCrossRefGoogle Scholar
  13. 13.
    D. Gospodarowicz and C.R. Ill, Extracellular matrix and control of proliferation of vascular endothelial cells, J. Clin, Invest. 65:1351 (1980).CrossRefGoogle Scholar
  14. 14.
    J.A. Madri and K.S. Stenn, Aortic endothelial cell migration. I. Matrix requirements and composition, Am. J. Pathol. 106:180 (1982).PubMedGoogle Scholar
  15. 15.
    E.G. Bade and G. Nitzgen, Extracellular matrix (ECM) modulates the EGF induced migration of liver cells in serum free, hormone supplemented medium. In Vitro 21:245 (1985).Google Scholar
  16. 16.
    B.R. McAuslan and W. Reilly, Endothelial cell phagokinesis in response to specific metal ions, Exp. Cell Res. 130:147 (1980).PubMedCrossRefGoogle Scholar
  17. 17.
    G.N. Hannan, J.W. Redman and B.R. McAuslan, Similarity of carbohydrate moieties of fibronectin derived from blood plasma and synthesized by cultured endothelial cells, Biochim. Biophys. Acta 801:396 (1984).PubMedCrossRefGoogle Scholar
  18. 18.
    J. Koch, T. Fifis, V. Bender and B.A. Moss, Molecular species of epidermal growth factor carrying immuno-suppressive activity, J. Cell Biochem. 25:45 (1984).PubMedCrossRefGoogle Scholar
  19. 19.
    B.R. McAuslan and H. Hoffman, Endothelium stimulating factor from Walker carcinoma cells: relation to tumor angiogenic factor, Exp. Cell Res. 119:181 (1979).PubMedCrossRefGoogle Scholar
  20. 20.
    B.R. McAuslan, W. Reilly, G.N. Hannan, K. Schindhelm, B. Milthorpe and B.A. Saur, Induction or endothelial cell migration by proine analogues and its relevance to angiogenesis, Exp. Cell Res. in press (1988).Google Scholar
  21. 21.
    B.R. McAuslan, V. Bender, W. Reilly and B.A. Moss, New functions of epidermal growth factor: stimulation of capillary endothelial cell migration and matrix dependent proliferation. Cell Biol. Int. Reps. 9:175 (1985).CrossRefGoogle Scholar
  22. 22.
    R.G. Azizkhan, J.C. Azizkhan, B.R. Zetter and J. Folkman, Mast cell heparin stimulates migration of capillary endothelial cells in vitro, J. Exp. Med. 152:931 (1980).CrossRefGoogle Scholar
  23. 23.
    J.B. Weiss, C.R. Hill, R.J. Davis and B. McLaughlin, Activation of mammalian procollagenase and basement membrane — degrading enzymes by a low molecular weight angiogenesis factor. Agents and Actions, 15:107 (1984).CrossRefGoogle Scholar
  24. 24.
    T. Kalebic, S. Oarbisa, B. Glaser and L.A. Liotta, Basement membrane collagen: degradation by migrating endothelial cells, Science July:283 (1983).Google Scholar
  25. 25.
    J.L. Gross, D. Moscatelli and D.B. Rifkin, Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro, Proc. Natl. Acad. Sci. USA, 80:2623 (1983).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • W. Reilly
    • 1
  • B. R. McAuslan
    • 1
  1. 1.CSIRO Division of Molecular BiologyNorth RydeAustralia

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