Transvascular and Interstitial Transport in Tumors

  • Rakesh K. Jain
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 242)


The advent of hybridoma technology and genetic engineering has led to a large scale production of monoclonal antibodies and other biologically useful molecules. Some of these molecules can bind to intra-or extracellular sites in tumors for detection and treatment, while others (e.g., lymphokines) have the ability to activate certain immune cells for killing cancer cells. Since these molecules or cells do not have the biological selectivity for tumors in vivo as previously envisioned, methods must be developed to deliver them selectively to the target in vivo. Since no molecule or cell can reach the tumor cells without passing through the vascular and interstitial compartments, it seems reasonable to find out more about the structure and function of these two compartments. In the past few years, we have focused our research on the experimental and mathematical characterization of transport through these spaces. I would like to share the results of some of these studies with you, and point out their implications for tumor growth, detection and treatment.


Convective Velocity Fluorescence Recovery After Photobleaching Microvascular Permeability Increase Tumor Size Tumor Periphery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Rakesh K. Jain
    • 1
  1. 1.Department of Chemical EngineeringCarnegie Mellon UniversityPittsburghUSA

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