Skip to main content

Microcirculatory Disturbances in Endotoxin-Induced Disseminated Intravascular Coagulation

The Effects of Heparin and Gabexate Mesilate on Locomotive and Metabolic Changes of Neutrophils

  • Chapter
Vascular Endothelium in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 242))

Abstract

It is well recognized that the intravenous administration of endotoxin causes a transient neutropenia followed by a systemic increase in neutrophils.1 The initial depression of neutrophils is considered as the result of adhesive changes of neutrophils to the endothelium.2

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. C.A. Stetson Jr., Studies on the mechanism of the Shwartzman phenomenon. Certain factors involved in the production of the local hemorrhagic necrosis, Exp. Med. 93:489 (1951).

    Article  Google Scholar 

  2. J.W. Athens, O.P. Haab, S.O. Raab, et al., Leukokinetic studies. IV. The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjects, J. Clin. Invest. 40:989 (1961).

    Article  PubMed  CAS  Google Scholar 

  3. D.C. Morrison and R.J. Ulevitch, The effects of bactrial endotoxin on host mediation system, Am. J. Pathol. 93:527 (1978).

    Google Scholar 

  4. T. Yoshikawa, M. Murakami, Y. Furukawa, et al., Lipid peroxidation and experimental disseminated intravascular coagulation in rats induced by endotoxin, Thromb. Haemostas. 49: 214 (1983).

    CAS  Google Scholar 

  5. R. Chambers and B.W. Zweifach, Topography and function of the mesentric circulation, Am. J. Anat. 75:173 (1944).

    Article  Google Scholar 

  6. T.H. Schoendorf, M. Rosenberg and F.W. Beller, Endotoxin-induced disseminated intravascular coagulation in nonpregnant rats. Am. J. Pathol. 65:51 (1971).

    PubMed  CAS  Google Scholar 

  7. U. Bagge and P. Karlson, Maintenance of white blood cell margination at the passage through small venular junctions, Microvasc. Res. 20:92 (1980).

    Article  PubMed  CAS  Google Scholar 

  8. H. Faden and N. Maciejewski, Whole blood luminol-dependent chemiluminescence, J. Reticuloendothelial Soc. 30(3): 219 (1981).

    CAS  Google Scholar 

  9. A.L. Sagone Jr., G.W. King and E.N. Metz, A comparison of the metabolic response to phagocytosisin human granulocytes and monocytes, J. Clin. Invest. 57:1352 (1976).

    Article  PubMed  CAS  Google Scholar 

  10. M. Suematsu, C. Oshio, S. Miura and M. Tsuchiya, Real-time visualization of oxyradical burst from single neutrophil by using ultrasensitive video intensifier microscopy, Biochem. Biophys. Res. Commun. 149(3): 1106 (1987).

    Article  PubMed  CAS  Google Scholar 

  11. M. Suematsu, S. Miura, M. Suzuki, H. Nagatk, T. Morishita, C. Oshio and M. Tsuchiya, 5-lipoxygenaseinhibitor (AA-861) attenuates neutrophil-mediated oxidative stress on the venular endothelium in endotoxemia,J. Clin. Lab. Immunol. 25:41–45 (1988).

    PubMed  CAS  Google Scholar 

  12. Y. Tamura, M. Hirado, K. Okamura, Y. Minato and S. Fujii, Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, GIF and CI esterase, Biochim. Biophys. Acta. 484:417–422 (1977).

    Article  PubMed  CAS  Google Scholar 

  13. M. Suematsu, H. Nagata, S. Miura, et al., Changes of respiratory burst of leukocytes and lipidperox-idation in microcirculatory disturbance, Japanese Journal of Circulation Research Vol. 9(2): 119–125 (1986).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Suzuki, M., Suematsu, M., Miura, S., Oshio, C., Oda, M., Tsuchiya, M. (1988). Microcirculatory Disturbances in Endotoxin-Induced Disseminated Intravascular Coagulation. In: Chien, S. (eds) Vascular Endothelium in Health and Disease. Advances in Experimental Medicine and Biology, vol 242. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8935-4_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8935-4_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8937-8

  • Online ISBN: 978-1-4684-8935-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics