Effect of Vitamin E on Prostacyclin Production from Cultured Aortic Endothelial Cells
Vitamin E is known as a preventive agent against the development of atherosclerosis.1 On the other hand, prostacyclin (PGI2) generated by vascular endothelial cell is considered to play an important role to keep the homeostasis in vascular wall.2–4 The reduction of PGI2 production can be proposed as one of the possible causes of atherosclerosis. In our previous study, human plasma derived serum (PDS) showed a prostacyclin stimulatory activity (PSA) on cultured bovine aortic endothelial cells. Furthermore, the reduction of PSA in PDS was observed in diabetic rats and diabetic patients.5,6 Since PSA can be one of the key modulators to the development of vascular lesions, the present study was done to evaluate the effect of vitamin E on PSA when stimulated by PDS.
KeywordsAortic Endothelial Cell Maximal Enhancement Bovine Aortic Endothelial Cell Prostacyclin Production Free Radical Peroxidation
Unable to display preview. Download preview PDF.
- 4.S. Moncada, E.A. Higgs and J.R. Vane, Human arterial and venous tissues generate prostacyclin (prostaglandin X), a potent inhibitor of platelet aggregation. Lancet i:18 (1977).Google Scholar
- 6.T. Inoguchi, F. Umeda, J. Watanabe and H. Ibayashi, Stimulatory activity on prostacyclin production decreases in sera from streptozotocin-induced diabetic rats, Diab. Res. Clin. Pract. 3:243.Google Scholar
- 12.C.W. Karpen, K.A. Pritchard Jr., J.H. Arnold, D.G. Cornwell and R.V. Panganamala, Restoration of prostacyclin/thromboxane Aj balance in the diabetic rat. Infulence of dietary vitamin E, Diabetes 31:947 (1982).Google Scholar
- 13.H. Sugumoto, M. Matumoto, T. Kimura and H. Ibayashi, The effect of vitamin E on the prostaglandin metabolism. Plasma lipoperoxide and aortic prostacyclin production in vitamin E deficient rats, J. Jpn. Atheroscler. Soc. 8:575 (1980).Google Scholar