Effect of Vitamin E on Prostacyclin Production from Cultured Aortic Endothelial Cells

  • Makoto Kunisaki
  • Fumio Umeda
  • Toyoshi Inoguchi
  • Hiroshi Ono
  • Yasuhiro Sako
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 242)


Vitamin E is known as a preventive agent against the development of atherosclerosis.1 On the other hand, prostacyclin (PGI2) generated by vascular endothelial cell is considered to play an important role to keep the homeostasis in vascular wall.2–4 The reduction of PGI2 production can be proposed as one of the possible causes of atherosclerosis. In our previous study, human plasma derived serum (PDS) showed a prostacyclin stimulatory activity (PSA) on cultured bovine aortic endothelial cells. Furthermore, the reduction of PSA in PDS was observed in diabetic rats and diabetic patients.5,6 Since PSA can be one of the key modulators to the development of vascular lesions, the present study was done to evaluate the effect of vitamin E on PSA when stimulated by PDS.


Aortic Endothelial Cell Maximal Enhancement Bovine Aortic Endothelial Cell Prostacyclin Production Free Radical Peroxidation 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Makoto Kunisaki
    • 1
  • Fumio Umeda
    • 1
  • Toyoshi Inoguchi
    • 1
  • Hiroshi Ono
    • 1
  • Yasuhiro Sako
    • 1
  1. 1.Third Department of Internal Medicine Faculty of MedicineKyushu UniversityFukuoka 812Japan

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