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Effect of Vitamin E on Prostacyclin Production from Cultured Aortic Endothelial Cells

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Vascular Endothelium in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 242))

Abstract

Vitamin E is known as a preventive agent against the development of atherosclerosis.1 On the other hand, prostacyclin (PGI2) generated by vascular endothelial cell is considered to play an important role to keep the homeostasis in vascular wall.2–4 The reduction of PGI2 production can be proposed as one of the possible causes of atherosclerosis. In our previous study, human plasma derived serum (PDS) showed a prostacyclin stimulatory activity (PSA) on cultured bovine aortic endothelial cells. Furthermore, the reduction of PSA in PDS was observed in diabetic rats and diabetic patients.5,6 Since PSA can be one of the key modulators to the development of vascular lesions, the present study was done to evaluate the effect of vitamin E on PSA when stimulated by PDS.

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Authors and Affiliations

  1. Third Department of Internal Medicine Faculty of Medicine, Kyushu University, Fukuoka 812, Japan

    Makoto Kunisaki, Fumio Umeda, Toyoshi Inoguchi, Hiroshi Ono & Yasuhiro Sako

Authors
  1. Makoto Kunisaki
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  2. Fumio Umeda
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  3. Toyoshi Inoguchi
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  4. Hiroshi Ono
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  5. Yasuhiro Sako
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Editor information

Editors and Affiliations

  1. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan Republic of China

    Shu Chien

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© 1988 Plenum Press, New York

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Kunisaki, M., Umeda, F., Inoguchi, T., Ono, H., Sako, Y. (1988). Effect of Vitamin E on Prostacyclin Production from Cultured Aortic Endothelial Cells. In: Chien, S. (eds) Vascular Endothelium in Health and Disease. Advances in Experimental Medicine and Biology, vol 242. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8935-4_13

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  • DOI: https://doi.org/10.1007/978-1-4684-8935-4_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8937-8

  • Online ISBN: 978-1-4684-8935-4

  • eBook Packages: Springer Book Archive

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