Leukocyte Endothelium Adhesion and Microvascular Hemodynamics

  • Herbert H. Lipowsky
  • Steven D. House
  • John C. Firrell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 242)


The effectiveness of the inflammatory response hinges upon the interaction between hemodynamic transport of white blood cells (WBCs) to a focus of adhesion on the endothelium and the shearing forces exerted by the blood stream which tend to dislodge them prior to emigration through the vascular wall.1,2 Within the micro vasculature, the preferential margination of WBCs along the venular endothelium predisposes leukocyte endothelium adhesion (LEA) when activation of adhesion complexes on the WBC and endothelial cell are initiated by an appropriate stimulus. Several mechanisms may promote the enhancement of venular WBC saltation, which may arise from either the kinematics of red blood cell (RBC) and WBC interaction,3 the hemodynamic influence of RBC aggregation at reduced shear rates,4 or the inherent rigidity of WBCs compared to RBCs.5,6


Shear Rate Wall Shear Stress Wall Shear Rate Cell Deformation Microvascular Blood Flow 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Herbert H. Lipowsky
    • 1
  • Steven D. House
    • 1
  • John C. Firrell
    • 1
  1. 1.Department of Physiology and Cellular Biophysics College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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