Abstract
Vaginitis by definition means inflammation of the vagina and is to be distinguished from cervicitis which has its own set of pathogens. We are aware of relatively few agents that cause vaginitis. Trichomonas vaginalis, a protozoan parasite, is usually associated with a voluminous, often frothy, green vaginal discharge. Yeast vaginitis is usually caused by the yeast-like fungus Candida albicans and is characterized by a curd-like vaginal discharge often associated with itching. Vaginitis caused by these two agents has been termed specific vaginitis and represents approximately 50% of all cases. Patients presenting to a physician with complaints of vaginitis but having evidence of neither T. vaginalis nor C. albicans were defined as having nonspecific vaginitis (NSV). NSV is not a new syndrome. As early as 1895, Kronig (1) published drawings of vaginal fluid from patients with NSV which showed a mixed flora devoid of large rods and including vibrio-like organisms. Later Doderlein (cited in reference 2) described three grades of vaginal flora. Grade I, defined as a clean vagina, contained large rod-shaped organisms which became known as Doderlein’s bacilli and represent various species of the genus Lactobacillus. Grade II was a mixed flora, and Grade III, the pathological flora, was notable by its absence of the large rod-shaped organisms. Kronig’s drawings and Doderlein’s description of the Grade III flora are characteristic of the syndrome we now call NSV.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
I. Kronig. Uber die Natur der Scheidenheme, Speciell über das vorkommen anaerorber Streptokokken in Scheidensekret Schwangerer. Centralbl. fur Gynakol. 19, 409, (1895).
R. Cruickshank, and A. Sharman. The biology of the vagina in the human subject. J. Obstet. Gynecol. Br. Emp. 41, 208, (1934).
K.K. Holmes, C. Spiegel, R. Amsel, D.A. Eschenbach, K.C.S. Chen, and P. Totten. Nonspecific vaginosis. Scand. J. Infect. Dis. Suppl. 26, 110, (1981).
H.L. Gardner, and C.D. Dukes Hemophilus vaginalis vaginitis. Am. J. Obstet. Gynecol. 69, 962, (1955).
T.A. Pheifer, P.S. Forsyth, M.A. Durfee, H.M. Pollock, and K.K. Holmes. Nonspecific vaginitis: Role of Haemophilus vaginalis and treatment with metronidazole. Engl. J. Med. 298, 1429, (1978).
R. Amsel, P.A. Totten, C.A. Spiegel, K.C.S. Chen, D. Eschenbach, and K.K. Holmes. Nonspecific vaginitis: Diagnostic criteria and microbial and epidemiologic associations. Am. J. Med. 74, 14, (1983).
S. Leopold. Heretofore undescribed organism isolated from genitourinary system. U.S. Armed Forces Med. J. 4, 263, (1953).
P. Piot, E. Van Dyck, M. Goodfellow, and S. Falkow. A taxonomie study of Gardnerella vaginalis (Haemophilus vaginalis) Gardner and Dukes. J. Gen. Microbiol. 119, 373, (1980).
J.R. Greenwood, and M.J. Pickett. Transfer of Haemophilus vaginalis Gardner and Dukes to a new genus, Gardnerella (Gardner and Dukes) comb. nov. Int. J. Syst. Bacterid. 30, 170, (1980).
W.M. McCormack, C.H. Hayes, B. Rosner, J.R. Evrard, V.A Crockett, S. Alpert, and S.H. Zinner. Vaginal colonization with Corynebacterium vaginale (Haemophilus vaginalis). J. Infect. Dis. 136, 740, (1977).
P.A. Totten, R. Amsel, J. Hale, P. Piot, and K.K. Holmes. Selective differential human blood bilayer media for isolation of Gardnerella (Haemophilus) vaginalis. J. Clin. Microbiol. 15, 141, (1982).
K.C.S. Chen, P.S. Forsyth, T.M. Buchanan, and K.K. Holmes. Biochemical aspects of nonspecific vaginitis: Amine content of vaginal fluid from untreated patients. J. Clin. Invest. 63, 828, (1979).
K.C.S. Chen, R. Amsel, D.A. Eschenbach, and K.K. Holmes. Biochemical diagnosis of vaginitis: Determination of diamines in vaginal fluid. J. Infect. Dis. 145, 337, (1982).
C.A. Spiegel, R. Amsel, D. Eschenbach, F. Schoenknecht, and K.K. Holmes. Anaerobic bacteria in nonspecific vaginitis, N. Engl. J. Med. 303, 601, (1980).
E. Taylor, A.L. Blackwell, D. Barlow, and I. Phillips. Gardnerella vaginalis, anaerobes, and vaginal discharge. Lancet, i, 1376, (1982).
A.L. Blackwell, A.R. Fox, I. Phillips, and D. Barlow. Anaerobic vaginosis (non-specific vaginitis): Clinical, microbiological, and therapeutic findings. Lancet. ii, 1379, (1983).
C.A. Spiegel, R. Amsel, and K.K. Holmes. Diagnosis of bacterial vaginosis by direct Gram stain of vaginal fluid. J. Clin. Microbiol. 18, 170, (1983).
C.A. Spiegel, D.A. Eschenbach, R. Amsel, and K.K. Holmes- Curved anaerobic bacteria in bacterial (nonspecific) vaginosis and their response to antimicrobial therapy. J. Infect. Dis. 148, 817, (1983).
J.L. Thomason, P.C. Schreckenberger, W.N. Spellacy, L.J. Riff, and L.J. LeBeau. Clinical and microbiological characterization of patients with nonspecific vaginosis associated with motile, curved anaerobic rods. J. Infect. Dis. 149, 801, (1984).
A.H. Curtis. A motile curved anaerobic bacillus in uterine discharges. J. Infect. Pis. 12, 165, (1913).
B. Moore. Observations on a group of anaerobic vaginal vibrios. J. Path. Bact. 67, 461, (1954).
R. Durieux, and A. Dublanchet. Les “Vibrions” anerobies des leucorrhees. Technique d’isolement et sensibilite aux antibiotiques. Med. Mal. Infect. 10, 109, (1980).
C. Pahlson, V. Forsum, A. Hallen, E. Hjelm, and J. Wallin. Characterization of motile anaerobic curved rods isolated from women with lower genital tract infection in three different countries. Eur. J. Sex. Trans. Pis. 1, 73, (1983).
A. Skarin, E. Hoist, and P.-A. Mardh. Antimicrobial susceptibility of comma-shaped bacteria isolated from the vagina. Scand. J. Infect. Pis. Suppl. 40, 81, (1983).
M.S. Sprott, H.R. Ingham, R.S. Pattman, R.L. Eisenstadt, G.R. Short, H.K. Narang, P.R. Sisson, and J.B. Selkon. Characteristics of motile curved rods in vaginal secretions. J. Med. Microbiol. 16, 175, (1983).
C.A. Spiegel, and M. Roberts, Mobiluncus gen. nov., Mobiluncus curtisii subspecies curtisii sp. nov., Mobiluncus curtisii subspecies holmesii subsp. nov., and Mobiluncus mulieris sp. nov., curved rods from the human vagina. Int. J. System Bacterid. 34, 177, (1984).
R. Hammann, A. Kronibus, A. Viebahn, and H. Brandis, Falcivibrio grandis gen. nov. sp. nov. and Falcivibrio vaginalis gen. nov. sp. nov., a new genus and species to accommodate anaerobic motile curved rods formerly described as “Vibrio mulieris” (Prevot 1940) Breed et al. 1948. System Appl. Microbiol. 5, 81, (1984).
R. Amsel, C.W. Critchlow, C.A. Spiegel, K.C.S. Chen, D. Eschenbach, K. Smith, and K.K. Holmes. Comparison of metronidazole, ampicillin, and amoxicillin for treatment of bacterial vaginosis (nonspecific vaginitis): Possible explanation for the greater efficacy of metronidazole. In U.S. Metronidazole Conference, Proceedings from a Symposium, (S.M. Finegold ed.), p. 225. Biomedical Information Corporation, New York, (1982).
P. Piot, E. Van Pyck, M. Peeters, J. Hale, P.A. Totten, and K.K. Holmes. Biotypes of Gardnerella vaginalis. J. Clin. Microbiol. 20, 677, (1984).
P.-A. Mardh, and S. Svensson. Hemagglutination by vaginal anaerobic curved rods and its inhibition by oligosaccharides. In Bacterial vaginosis, (P.-A. Mardh and D. Taylor-Robinson ed.)., Almqvist & Wiskell International, Stockholm, 179, (1984).
B. Fredericsson, A.-K. Moller, and C.E. Nord. Can Gardnerella vaginalis and anaerobic curved rods attach to vaginal epithelial cells in vitro, resulting in clue cells. In Bacterial vaginosis, (P.-A. Mardh and P. Taylor-Robinson ed.), Almqvist & Wiskell International, Stockholm, 195, (1984).
H. Moi, P. Panielsson, and F. Schoenknecht. An in vitro study of the attachment to vaginal epithelial cells and anaerobic curved rods, Bacteriodes bivius and Bacterioides disiens. In Bacterial vaginosis, (P.-A. Mardh and P. Taylor-Robinson ed.), Almqvist & Wiskell International, Stockholm, 185, (1984).
C.A. Ison, and C.S.F. Easmon. Studies on the mechanism of adhesion of Gardnerella vaginalis to human erythrocytes. In Bacterial vaginosis, (P.-A., Mardh and P. Taylor-Robinson ed.), Almqvist & Wiskell International, Stockholm, 191, (1984).
A.P. Johnson, C.A. Ison, C.M. Hetherington, M.F. Osborn, G. Southerton, W.T. London, C.S.F. Easmon, and P. Taylor-Robinson. Vaginal colonization of pig-tailed macaques by Gardnerella vaginalis. In Bacterial vaginosis, (P.-A. Mardh and P. Taylor-Robinson ed). Almqvist & Wiskell International, Stockholm, 207, (1984).
P.-A. Mardh, E, Hoist, and B.R. Moller. The grivet monkey as a model for study of vaginitis. Challenge with anaerobic curved rods and Gardnerella vaginalis. In Bacterial vaginosis, (P.-A. Mardh and P. Taylor-Robinson ed.). Almqvist & Wiskell International, Stockholm, 201, (1984).
C.E. Nord and B. Olsson-Liljequist. Resistance to -lactam antibiotics in Bacteroides species. J. Antimicrob. Chemother. 8 Suppl. D, 33, 1981.
E.D. Ralph, and Y.E. Amatnieks. Relative susceptibilities of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to metronidazole and its two major metabolites. Sex. Trans. Dis. 1, 157, 1980.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Spiegel, C.A. (1987). New Developments in the Etiology and Pathogenesis of Bacterial Vaginosis. In: Bondi, A., Stieritz, D.D., Campos, J.M., Miller, L.A. (eds) Urogenital Infections. Advances in Experimental Medicine and Biology, vol 224. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8932-3_12
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8932-3_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8934-7
Online ISBN: 978-1-4684-8932-3
eBook Packages: Springer Book Archive