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Impairment of Intraneural Microcirculation, Blood-Nerve Barrier and Axonal Transport in Experimental Nerve Ischemia and Compression

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The Neurobiologic Mechanisms in Manipulative Therapy

Abstract

Studies on experimental ischemia and compression of peripheral nerves are reviewed. It is concluded that any trauma to a nerve trunk may induce microvascular injury in the nerve. A slight trauma may cause epineurial micro-bleedings, oedema, etc. Severe trauma, e.g., prolonged experimental tourniquet ischemia or compression, involves injury to endoneurial capillaries (blood-nerve barrier) leading to intrafascicular oedema. The establishment of post-ischemic or post-traumatic interfascicular oedema coincides in time with severe disturbances in nerve function.

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Author information

Authors and Affiliations

  1. Institute of Neurobiology, Fack, S-400 33, Göteborg 33, Sweden

    J. Sjöstrand

  2. Laboratory of Experimental Biology, Department of Anatomy, Sweden

    B. Rydevik & G. Lundborg

  3. Department of Ophthalmology, Sweden

    J. Sjöstrand

  4. Division of Hand Surgery, Department of Orthopaedic Surgery I, University of Göteborg, Göteborg, Sweden

    G. Lundborg

  5. Department of Pharmacology, School of Pharmacy, Liverpool Polytechnic, Liverpool, England

    W. G. McLean

Authors
  1. J. Sjöstrand
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  2. B. Rydevik
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  3. G. Lundborg
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  4. W. G. McLean
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Editor information

Editors and Affiliations

  1. Michigan State University, USA

    Irvin M. Korr

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© 1978 Plenum Press, New York

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Sjöstrand, J., Rydevik, B., Lundborg, G., McLean, W.G. (1978). Impairment of Intraneural Microcirculation, Blood-Nerve Barrier and Axonal Transport in Experimental Nerve Ischemia and Compression. In: Korr, I.M. (eds) The Neurobiologic Mechanisms in Manipulative Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8902-6_15

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  • DOI: https://doi.org/10.1007/978-1-4684-8902-6_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8904-0

  • Online ISBN: 978-1-4684-8902-6

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