Abstract
Several antipsychotic agents produce extrapyramidal side effects which resemble Parkinson’s disease (Hollister, 1972; Hornykiewicz, 1973). It is generally agreed that these side effects may arise from the ability of these drugs to block the dopamine receptor of the caudate nucleus (Carlsson and Lindqvist, 1963; Nyback and Sedvall, 1968). Biochemical and pharmacological studies have suggested an intimate association between the dopamine receptor and a dopamine-sensitive adenylate cyclase in the caudate since the properties of the enzyme mimicked in large part the actions of the dopamine receptor (Kebabian, Petzold and Greengard, 1972; Clement-Cormier, Kebabian, Petzold and Greengard, 1974; Iverson, 1975; Anden and Stock, 1973).
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Clement-Cormier, Y. (1978). Cyclic Nucleotides in Neuroendocrine Function. In: Finch, C.E., Potter, D.E., Kenny, A.D. (eds) Parkinson’s Disease—II. Advances in Experimental Medicine and Biology, vol 113. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8893-7_12
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DOI: https://doi.org/10.1007/978-1-4684-8893-7_12
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