Skip to main content

Age-Dependent Changes in Central Dopaminergic and Other Monoaminergic Systems

  • Chapter
Book cover Parkinson’s Disease—II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 113))

Abstract

This presentation will focus on three apparently critical stages during the life-span of central dopaminergic neurons: (1) the vulnerable period of differentiation in pre- and early post- natal life; (2) the changes at puberty, induced by the sexual hor- mones; and (3) the decline of brain dopamine during adult life. Other monoaminergic neurons will also be discussed for the purpose of comparison.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adolfsson, R., Gottfries, C.G. and Winblad, В. (1976). Methodologi- cal aspects of postmortem investigations of human brain with special reference to monoamines and enzymes. Paper presented at Xth CINP meeting, Quebec, Canada.

    Google Scholar 

  • Agrawal, H.C and Himwich, W.A. (1970). Aminoacids, proteins, and monoamines of developing brain. In: Developmental neurobiologys pp. 287–310. Ed. W.A. Himwich. Springfield: Ch. С. Thomas.

    Google Scholar 

  • Ahlenius, S., Engel, J., Hard, E., Larsson, K., Lundborg, P. and Sinnerstedt, P. (1977). Open field behavior and gross motor development in offspring of nursing rat mothers given pen- fluridol. Pharmacology, Biochemistry and Behavior 6, 343–347.

    Article  CAS  Google Scholar 

  • Algeri, S., Ponzio, F., Bonati, M. and Brunello, N. (1976). Bio- chemical changes in monoaminergic nerves in the CNS of the senescent rat. Paper presented at Xth CINP meeting, Quebec, Canada.

    Google Scholar 

  • Bertler, A. (1961). Occurrence and localization of catechol- amines in the human brain. Acta, physiol scand. 51, 97–107.

    Article  CAS  Google Scholar 

  • Bowen, D.M., Smith, C.B., White, P. and Davidson, A.N. (1976). Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain 99, 459–496.

    Article  PubMed  CAS  Google Scholar 

  • Brambilla, F., Guerrine, A., Rizzi, F. and Ricciardi, F. (1974). Psychoendocrine investigations in schizophrenia: Relation- ship between pituitary-gonadal function and behavior. Dis. Nerv. Syst. 2, 362–367.

    Google Scholar 

  • Brody, H. (1973). Aging of the vertebrate brain. In: Development and aging in the nervous system, pp. 121–133. Eds. M. Rock- stein and M.L. Sussman. New York: Adac. Press.

    Chapter  Google Scholar 

  • Brody, K. (1977). Paper presented at Symposium on Aging, Institut de la Vie, Vichy, France.

    Google Scholar 

  • Carlsson, A. (1977). Does dopamine play a role in schizophrenia? Psychological Medicine 7, 583–597.

    Article  PubMed  CAS  Google Scholar 

  • Carlsson, A. and Lindqvist, M. (1978). Dependence of 5-HT and catecholamine synthesis on precursor aminoacid levels in rat brain, in preparation.

    Google Scholar 

  • Carlsson, A., Lindqvist, M. and Kehr, W. (1974). Postmortal accu- mulation of 3-methoxytyramine in brain. Nauyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 284, 365–372.

    Article  CAS  Google Scholar 

  • Carlsson, A. and Winblad, B. (1976). Influence of age and time interval between death and autopsy on dopamine and 3-methoxy- tyramine levels in human basal ganglia. J. Neural Transm. 38, 271–276.

    Article  PubMed  CAS  Google Scholar 

  • Connor, J.D. and Neff, N.H. (1970). Dopamine concentration in the caudate nucleus of the developing cat. Life Sci. 9, 1165–1168.

    Article  CAS  Google Scholar 

  • Davies, P. and Maloney, A.J.F. (1976). Selective loss of central cholinergic neurons in Alzheimer’s disease. Lancet ii, 1403.

    Article  Google Scholar 

  • Engel, J., Ahlenius, S., Almgren, O. and Carlsson, A. (1978). Effects of gonadectomy and hormone replacement on brain-mono- amine synthesis in male rats, in preparation.

    Google Scholar 

  • Finch, C. (1976). The regulation of physiological changes during mammalian aging. Q. Rev. Biol. 51, 49–83.

    Article  PubMed  CAS  Google Scholar 

  • Gottfries, C.G. (1978). Biochemical determinants of dementia. In: Handbook of biological psychiatry. Brain mechanisms and abnormal behavior, Vol. 2, Eds. H.H. van Praag, M.G. Lader, C.J. Rafaelsen and E.J. Sachar. New York: Marcel Dekker, Inc.

    Google Scholar 

  • Gottfries, C.G., Gottfries, I. and Roos, B-E, (1969). The inves- tigation of homovanillic acid in the human brain and its correlation to senile dementia. Br. J. Psychiat. 225, 563–574.

    Article  Google Scholar 

  • Granerus, A.-K. (1977). L-Dopa treatment in Parkinson’s syndrome. Thesis. Kungälv. Sweden: Gotab.

    Google Scholar 

  • Lehmann, J. (1966). Mental disturbances followed by stupor in a patient with carcinoidosis. Acta psychiat. scand. 42, 153 – 161.

    Article  PubMed  CAS  Google Scholar 

  • Loizou L.A. (1972). The postnatal ontogeny of monoamine-contain- ing neurons in the central nervous system of the albino rat, Brain Res. 40, 395–418.

    Article  PubMed  CAS  Google Scholar 

  • Lundborg, P. (1972). Abnormal ontogeny in young rabbits after chronic administration of haloperidol to the nursing mothers. Brain Res. 44,684–681.

    Article  PubMed  CAS  Google Scholar 

  • Lundborg, P. and Engel, J. (1975). Learning deficits and selective biochemical brain changes in 4-week old offspring of nursing rat mothers treated with neuroleptics. In: Antipsychotic drugs: pharmacodynamics and pharmacokinetics, pp. 261–269. Eds. G. Sedvall, B. Uvnds and Y. Zotterman. Oxford: Per- gamon Press.

    Google Scholar 

  • Lundborg, P. and Kellogg, C. (1973). Pharmacological approaches to monoamine receptors during brain development. In: Dy- namics of degeneration and growth in neurons, pp. 561–573. Eds. K. Fuxe, L. Olson and Y. Zotterman. Oxford: Pergamon Press.

    Google Scholar 

  • Manshardt, J. and Wurtman, R.J. (1968). Daily rhythym in the nor- adrenaline content of rat hypothalamus. Nature 217, 574–575.

    Article  PubMed  CAS  Google Scholar 

  • McGeer, P.L. and McGeer, E.G. (1976). Enzymes associated with the metabolism of catecholamines, acetylcholine, and gaba in human controls and Datients with Parkinson’s disease and Huntingtons chorea. J. Neurochem. 26, 65–76.

    PubMed  CAS  Google Scholar 

  • McKean, Ch. M. (1972). The effects of high phenylalanine concen- trations on serotonin and catecholamine metabolism in the human brain. Brain Res. 47, 469–476.

    Article  PubMed  CAS  Google Scholar 

  • Perry, E.K., Perry, R.H., Blessed, G. and Tomlinson, B.E. (1977). Necropsy evidence of central cholinergic deficits in senile dementia. Lancet i, 189.

    Article  Google Scholar 

  • Reis, D.J., Weinbren, M. and Corvelli, A. (1968). A circadian rhythm of norepinephrine regionally in cat brain: its rels- tionship to environmental lighting and to regional diurnal variations in brain serotonin. J. Pharmac. exp. Ther. 164. 135–145.

    CAS  Google Scholar 

  • Strombom, U., Svensson, R.J., Jackson, C.M. and Engstrom, G. (1977). Hyperthyroidism: Specifically increased response to central NA-(α-)receptor stimulation and generally increased monoamine turnover in brain. J. Neural Transm. 41, 73–92.

    Article  PubMed  CAS  Google Scholar 

  • White, P., Goodhardt, M.J., Keet, J.P., Hiley, C.R., Carrasco, L.H. and Williams, I.E.I. (1977). Neurocortical cholinergic neurons in elderly people. Lancet i, 668.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Plenum Press, New York

About this chapter

Cite this chapter

Carlsson, A. (1978). Age-Dependent Changes in Central Dopaminergic and Other Monoaminergic Systems. In: Finch, C.E., Potter, D.E., Kenny, A.D. (eds) Parkinson’s Disease—II. Advances in Experimental Medicine and Biology, vol 113. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8893-7_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8893-7_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8895-1

  • Online ISBN: 978-1-4684-8893-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics