Abstract
Based on the Krogh tissue cylinder, a lumped parameter mathematical model was developed to describe multicomponent transport and metabolic reaction processes in brain. Utilizing the mathematical model, computer solutions were obtained for a wide range of patho-physiologic conditions. Varying degrees of ischemia were imposed on arterial blood flow in order to examine the metabolic state of brain tissue during reduced oxygen supply. The major purpose of the study was to observe the effects created in tissue at extremely low flow rates, including complete flow cessation.
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References
Krogh, A. (1922) The Anatomy and Physiology of Capillaries. Yale University Press.
Null, R.E. (1976) Ph.D. Dissertation, Louisiana Tech University, Ruston, La., U.S.A.
Siesjo, B.K., Nordstrom, C.H. and Rehncrona, S. (1977) Adv. Exp. Med. Biol. 78, 261.
Silver, I.A. (1977) Adv. Exp. Med. Biol. 78, 299.
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© 1978 Plenum Press, New York
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Null, R.E., Reneau, D.D. (1978). A Computer Analysis of Graded Ischemia in Brain. In: Silver, I.A., Erecińska, M., Bicher, H.I. (eds) Oxygen Transport to Tissue — III. Advances in Experimental Medicine and Biology, vol 94. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-8890-6_30
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DOI: https://doi.org/10.1007/978-1-4684-8890-6_30
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