Abstract
Several immunologically mediated mechanisms may lead to injury of renal tubules and interstitial tissue resulting in tubulointer-stitial nephritis (TIN). The distinguishing features of these mechanisms are based upon their immunofluorescent microscopic (IF) pattern. Tubular linear deposits of immunoglobulins (Ig) suggest the presence of circulating antitubular basement membrane (TBM) antibodies. Granular deposits of Ig and/or complement (C) are likely related to the presence of immune complexes (IC). In the absence of deposits, a cell-mediated reaction may be suggested. These mechanisms have been well studied in experimental models. They may also be observed in man. We report about 14 children with proven or presumed immunologically mediated TIN.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Habib, R., Levy, M. (1981). Highlights Immunologically Mediated Tubulointerstitial Nephritis in Children. In: Strauss, J. (eds) Pediatric Nephrology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8804-3_13
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8804-3_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8806-7
Online ISBN: 978-1-4684-8804-3
eBook Packages: Springer Book Archive