The Neural and Hormonal Bases of the Reproductive Cycle of the Rat

  • R. A. Gorski
  • S. P. Mennin
  • K. Kubo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 54)


The reproductive cycle of the female mammal is one of the most important biological rhythms. Through the coordination of vaginal, ovarian, pituitary, neuroendocrine and behavioral rhythms, reproduction and the propagation of the species is made possible. This reproductive cycle, which in large measure is a manifestation of the regulation of pituitary gonadotropin (GTH) secretion by the central nervous’system (CNS), has several distinctive characteristics: 1) Although related to the daily light cycle, the period of the reproductive cycle is much longer, ranging from four or five days in the rat (which will be the principal species considered in this discussion), to the monthly cycle of the human. 2) Although clearly a manifestation of a neural rhythm, the normal expression of that rhythm is totally dependent on the feedback action of gonadal hormones. 3) Although this biological rhythm is sexually dimorphic, ontogenic studies have demonstrated that it is determined by the hormone environment at a Crotocal Period in development.


Luteinizing Hormone Estrous Cycle Reproductive Cycle Luteinizing Hormone Surge Testosterone Propionate 
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Discussion References

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • R. A. Gorski
    • 1
  • S. P. Mennin
    • 1
  • K. Kubo
    • 1
  1. 1.Department of Anatomy and Brain Research InstituteUCLA School of MedicineLos AngelesUSA

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