Skip to main content

Endocrine Rhythms Associated with Pineal Gland Function

  • Chapter
Biological Rhythms and Endocrine Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 54))

Abstract

The endocrine system exhibits a gamut of rhythms. Many of these have a duration of roughly 24 hours (circadian) while some are approximately 12 months (circannual) in length. All of the rhythms are probably advantageous to the individual animals or to the species as a whole. The factors controlling many of these hormonal fluctuations are likely numerous; and, in many cases, the governing mechanisms remain unknown. Some of the rhythms are undoubtedly related to the activity of the pineal gland, an organ which itself exhibits remarkable variations in its biosynthetic and presumably in its secretory activity. In the pineal gland, the primary impeller of these changes is ostensibly the photoperiodic environment (Quay, 1963a; Axelrod, Wurtman, and Snyder, 1965; Snyder, Axelrod, and Zweig, 1967) and to somewhat lesser extent locomotor activity (Ralph, Mull, Lynch, and Hedlund, 1971; Reiter, Sorrentino, Ralph, Lynch, Mull, and Jarrow, 1971) and hormonal feedback influences (Quay, 1964; Wurtman, Axelrod, Snyder, and Chu, 1965; Houssay and Barcello, 1972).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albertazzi, E., Barbanti-Silva, C., Trentini, G. P., and Botticelli, A. (1966). Influence de l’epiphysectomie et du traitement avec la 5-hydroxytryptamine sur le cycle oestral de la ratte albinos. Ann. Endocrinol. 27, 93–100.

    Google Scholar 

  • Allen, C., and Kendall, J. W. (1967). Maturation of the circadian rhythm of plasma corticosterone in the rat. Endocrinology 80, 926–930.

    Article  PubMed  CAS  Google Scholar 

  • Alleva, J. J., Waleski, M. V., and Alleva, F. R. (1970). The Zeitgeber for ovulation in rats: non-participation of the pineal gland. Life Sci. 9, 241–246.

    Article  PubMed  CAS  Google Scholar 

  • Axelrod, J., and Weissbach, H. (1960). Enzymatic O-methylation of N-acetylserotonin to melatonin. Science 131, 1312.

    Article  PubMed  CAS  Google Scholar 

  • Axelrod, J., Wurtman, R. J., and Snyder, S. H. (1965). Control of hydroxyindole-O-methyltransferase activity in the rat pineal gland by environmental lighting. J. Biol. Chem. 240, 949–954.

    PubMed  CAS  Google Scholar 

  • Benson, B., Matthews, M. J., and Rodin, A. (1971). A melatonin-free extract of bovine pineal with anti gonadotropic activity. Life Sci. 10, 607–613.

    Article  CAS  Google Scholar 

  • Benson, B., Matthews, M. J., and Rodin, A. (1972). Studies on a non-melatonin pineal anti gonadotropin. Acta Endocrinol. 69, 257–266.

    PubMed  CAS  Google Scholar 

  • Benson, B., and Orts, R. J. (1972). Regulation of ovarian growth by the pineal aland. In: Regulation of Organ and Tissue Growth (Goss, R. J., ed.), pp. 315–335, Academic Press, New York.

    Google Scholar 

  • Butcher, R. L., Fugo, N. W., and Collins, W. E. (1972). Semicircadian rhythm in plasma levels of prolactin during early gestation in the rat. Endocrinology 90, 1125–1127.

    Article  PubMed  CAS  Google Scholar 

  • Cardinali, D. P., and Rosner, J. J. (1971). Retinal localization of the hydroxyindole-O-methyltransferase (HI0MT) in the rat. Endocrinology 89, 301–303.

    Article  PubMed  CAS  Google Scholar 

  • Cardinali, D. P., and Wurtman, R. J. (1972). Hydroxyindole-O-methyltransferase in the rat pineal, retina and Harderian gland. Endocrinology 91, 247–252.

    Article  PubMed  CAS  Google Scholar 

  • Chazov, Ye. I., Isachenkov, V. A., Krisvosheyev, O. G., Veselova, S. N., and Zhivoderova, G. V. (1972). A factor from the pineal body inhibiting the ovulation induced by luteinizing hormone. Dokl. Acad. Nauk. SSSR, 27, 246–248 (In Russian).

    Google Scholar 

  • Cheesman, D. W. (1970). Structure elucidation of a gonadotropin inhibiting substance from the bovine pineal gland. Biochim. Biophys. Acta 207, 247–253.

    PubMed  CAS  Google Scholar 

  • Cheifez, P., Gaffud, N., and Dingman, J. F. (1968). Effects of bilateral adrenalectomy and continuous light on the circadian rhythm of corticotropin in female rats. Endocrinology 82, 1117–1124.

    Article  Google Scholar 

  • Clark, R. H., and Baker, B. L. (1964). Circadian periodicity in the concentration of prolactin in the rat hypophysis. Science 143, 375–376.

    Article  PubMed  CAS  Google Scholar 

  • Cuello, A. C., and Tramezzani, J. H. (1969). The epiphysis cerebri of the Weddell seal: its remarkable size and glandular pattern. Gen. Comp. Endocrinol. 12, 154–164.

    Article  PubMed  CAS  Google Scholar 

  • Donofrio, R. J., and Reiter, R. J. (1972). Depressed pituitary prolactin levels in blinded anosmic female rats: role of the pineal gland. J. Reprod. Fertil. 31, 159–162.

    Article  PubMed  CAS  Google Scholar 

  • Dunn, J., Dyer, R., and Bennett, M. (1972). Diurnal variation in plasma corticosterone following long term exposure to continuous illumination. Endocrinology 90, 1660–1663.

    Article  PubMed  CAS  Google Scholar 

  • Dunn, J., Bennett, M., and Peppier, P.. (1972). Pituitary-adrenal function in photic and olfactory deprived rats. Proc. Soc. Exptl. Biol. Med. 140, 755–758.

    CAS  Google Scholar 

  • Dunn, J. D., Arimura, A., and Scheving, L. E. (1972). Effect of stress on circadian periodicity in serum LH and prolactin concentration. Endocrinology 90, 29–33.

    Article  PubMed  CAS  Google Scholar 

  • Ebels, I., Moszkowska, A., and Scemama, A. (1970). An attempt to separate a sheep pineal extract fraction showing antigonadotropic activity. J. Neurovisc. Rel. 32, 1–10.

    CAS  Google Scholar 

  • Eiden, C. A., Keyes, M. C., and Marshall, C. E. (1971). Pineal body of the northern fur seal (Callorhinus ursinus): a model for studying the probable function of the mammalian pineal body. Am. J. Vet. Res. 32, 639–647.

    Google Scholar 

  • Everett, J. W. (1961). The mammalian female reproductive cycle and its controlling mechanisms. In: Sex and Internal Secretions, Vol. I, (Young, W. C., ed.), pp. 497–555, Williams and Wilkins, Baltimore.

    Google Scholar 

  • Figala, J., Hoffmann, K., and Goldau, G. (1973). Zur Jahresperiodik beim Dsungarischen Zwerghamster Phodopus sungorus Pallas. Oecologia 12, 89–118.

    Article  Google Scholar 

  • Fraschini, F. and Martini, L. (1970). Rhythmic phenomena and pineal principles. In: The Hypothalamus (Martini, L., Fraschini, F., and Motta, M., eds.), pp. 529–549, Academic Press, New York.

    Google Scholar 

  • Freeman, M. E., and Neill, J. D. (1972). The pattern of prolactin secretion during pseudopregnancy in the rat: a daily nocturnal surge. Endocrinology 90, 1291–1294.

    Google Scholar 

  • Giarman, N. J., Freedman, D. X., and Picard-Ami, L. (1960). Serotonin content of the pineal gland of man and monkey. Nature 186, 480–481.

    Article  PubMed  CAS  Google Scholar 

  • Hakanson, R., and Owman, C. (1966). Pineal dopa decarboxylase and monoamine oxidase activities as related to monoamine stores. J. Neurochem. 13, 597–605.

    Article  PubMed  CAS  Google Scholar 

  • Herbert, J. (1971). The role of the pineal gland in the control by light of the reproductive cycle of the ferret. In: The Pineal Gland (Wolstenholme, G. E. W. and Knight, J., eds.), pp. 303–327, Churchill Livingstone, London.

    Google Scholar 

  • Herbert, J. (1972). Initial observations on pinealectomized ferrets kept for long periods in either daylight or artificial illumination. J. Endocrinol. 55, 591–597.

    Article  PubMed  CAS  Google Scholar 

  • Hiroshige, T., Abe, K., Wada, S., and Kaneko, M. (1973). Sex differences in circadian periodicity of CRF activity in rat hypothalamus. Neuroendocrinology 11, 306–320.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman, R. A., Hester, R. J., and Towns, C. (1965). Effect of light and temperature on the endocrine system of the golden hamster (Mesocricetus auratus Waterhouse). Comp. Biochem. Physiol. 15, 525–533.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman, R. A., and Reiter, R. J. (1965). Pineal gland: influence on gonads of male hamsters. Science 148, 1609–1611.

    Article  PubMed  CAS  Google Scholar 

  • Hoffmann, K. (1972). Melatonin inhibits photoperiodically induced testes development in a dwarf hamster. Naturwissenschaften 59, 218–219.

    Article  PubMed  CAS  Google Scholar 

  • Hoffmann, K. (1973). The influence of photoperiod and melatonin on testes size, body weight, and pelage colour in the Djungarian hamster (Phodopus sungorus). J. Comp. Physiol. 85, 267–282.

    Article  CAS  Google Scholar 

  • Houssay, A. B., and Barcello, A. C. (1972). Effects of estrogens and progesterone upon the biosynthesis of melatonin by the pineal gland. Experientia 28, 478–479.

    Article  PubMed  CAS  Google Scholar 

  • Illnerova, H. (1971). Effect of environmental lighting on serotonin rhythm in rat pineal gland during postnatal development. Life Sci. 10, 583–590.

    Article  CAS  Google Scholar 

  • Jacobs, J. J., and Kendall, J. W. (1972). The effect of the pineal on rhythmic pituitary-adrenal function in the blinded rat. Abstracts of Fourth International Congress of Endocrinology, Washington, D.C., p. 53 (Abstract).

    Google Scholar 

  • Kamberi, I. A., Mical, R. S., and Porter, J. C. (1971). Effects of melatonin and serotonin on the release of FSH and prolactin. Endocrinology 88, 1288–1293.

    Article  PubMed  CAS  Google Scholar 

  • Klein, D. C., Reiter, R. J., and Weiler, J. L. (1971). Pineal N-acetyltransferase activity in blinded and anosmic rats. Endocrinology 89, 1020–1023.

    Article  PubMed  CAS  Google Scholar 

  • Klein, D. C., and Weiler, J. L. (1970). Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase. Science 169, 1093–1095.

    Article  PubMed  CAS  Google Scholar 

  • Lawton, I. E., and Schwartz, N. B. (1968). A circadian rhythm of luteinizing hormone secretion in ovariectomized rats. Am. J. Physiol. 214, 213–217.

    PubMed  CAS  Google Scholar 

  • Lerner, A. B., Case, J. D., and Takahashi, Y. (1960). Isolation of melatonin and 5-methoxyindole-3-acetic acid. J. Biol. Chem. 235, 1992–1997.

    PubMed  CAS  Google Scholar 

  • Lerner, A. B., Case, J. D., Takahashi, Y., Lee, T. H., and Mori, W. (1958). Isolation of melatonin, the pineal gland factor that lightens melanocytes. J. Am. Chem. Soc. 80, 2587.

    Article  CAS  Google Scholar 

  • Longnecker, D. E., and Gallo, D. G. (1971). The inhibition of PMSG-induced ovulation in immature rats by melatonin. Proc. Soc. Exp. Biol. Med. 137, 623–625.

    Google Scholar 

  • Lynch, H. J. (1971). Diurnal oscillations in pineal melatonin content. Life Sci. 10, 791–795.

    Article  CAS  Google Scholar 

  • Martini, L., Fraschini, F., and Motta, M. (1968). Neural control of the anterior pituitary. Recent Prog. Horm. Res. 24, 439–496.

    PubMed  CAS  Google Scholar 

  • McGeer, E. G., and McGeer, P. L. (1966). Circadian rhythm in pineal tyrosine hydroxylase. Science 153, 73–74.

    Article  PubMed  CAS  Google Scholar 

  • Mclsaac, W. M., Farrell, G., Taborsky, R. G., and Taylor, A. N. (1965). Indole compounds: isolation from pineal tissue. Science 145, 102–103.

    Article  Google Scholar 

  • Mclsaac, W. M., Taborsky, R. G., and Farrell, G. (1964). 5-methoxytryptophol: effect on estrus and ovarian weight. Science 145, 63–64.

    Article  Google Scholar 

  • Milcu, S. M., Pavel, S., and Neascu, C. (1963). Biological and chromatographic characterization of a polypeptide with pressor and oxytocic activities isolated from bovine pineal gland. Endocrinology 72, 563–566.

    Article  Google Scholar 

  • Mogler, R. K.-H. (1958). Das Endokrine System des Syrischen Goldhamster unter Berucksichtigung des Natürlichen und Experimentallen Winterschlaf. Z. Morphol. Öekl. Tiere. 47, 167–308.

    Google Scholar 

  • Morin, L. P. (1973). Ovulatory and body weight response of the hamster to constant light or pinealectomy. Neuroendocrinology 12, 192–198.

    Article  PubMed  CAS  Google Scholar 

  • Moszkowska, A. (1965). Quelques données nouvelles sur le mecanisme de l’antagonisme épiphyso-hypophysaire. Rôle possible de la Sérotonine et de la mélatonine. Rev. Suisse Zool. 72, 145–160.

    PubMed  CAS  Google Scholar 

  • Moszkowska, A., and Ebels, I. (1971). The influence of the pineal body on the gonadotropic function of the hypophysis. J. Neurovisc. Rel., Suppl. X, 160–176.

    Google Scholar 

  • Muller, E. E., Guistina, G., Miedico, D., Pecile, A., Cocchi, D., and King, F. W. (1970). Circadian pattern of bioassayable and radio-immunoassayable growth hormone in the pituitary of female rats. Proc. Soc. Exp. Biol. Med. 135, 934–939.

    PubMed  CAS  Google Scholar 

  • Nesić, Lj. (1962). Contribution a l’etude du rythme saisonnier de la grande pinéale de brebis. Acta Anat. 49, 376–377 (Abstract).

    Google Scholar 

  • Pavel, S. (1963). Cercetari aspura unui nou hormon pineal cu structura peptidica. Cercet. Endocrinol. 14, 665–668.

    CAS  Google Scholar 

  • Pavel, S. (1971). Evidence for the ependymal origin of arginine vasotocin in the bovine pineal gland. Endocrinology 89, 613–614.

    Article  PubMed  CAS  Google Scholar 

  • Pavel, S., Petrescu, M., and Vicoleanu, N. (1973). Evidence of central gonadotropin inhibiting activity of arginine vasotocin in the female mouse. Neuroendocrinology 11, 370–374.

    Article  PubMed  CAS  Google Scholar 

  • Pelham, R. W., and Ralph, C. L. (1972). Diurnal rhythm of serum melatonin in chicken: abolition by pinealectomy. Physiologist 15, 236 (Abstract).

    Google Scholar 

  • Pelham, R. W., Ralph, C. L., and Campbell, I. M. (1972). Mass spectral identification of melatonin in blood. Biochem. Biophys. Res. Com. 46, 1236–1241.

    Article  PubMed  CAS  Google Scholar 

  • Pelham, R. W., Vaughan, G. M., Sandock, K. L., and Vaughan, M. K. (1973). Twenty-four hour cycle of a melatomin-1ike substance in the plasma of human males. J. Clin. Endocrinol. Metab. 37, 341–344.

    Article  Google Scholar 

  • Pflügfelder, O. (1956). Physiologie der Epiphyse. Deut. Zool. Gesell. Verh. 50, 53–75.

    Google Scholar 

  • Porter, J. C., Mical, R. S., and Cramer, O. M. (1971/1972). Effect of serotonin and other indoles on the release of LH, FSH and prolactin. Gynecol. Invest., 2, 13–22.

    Article  Google Scholar 

  • Quay, W. B. (1956). Volumetric and cytologic variation in the pineal body of Peromyscus leucopus (Rodentia) with respect to sex, captivity and day-length J. Morphol. 98, 471–495.

    Article  CAS  Google Scholar 

  • Quay, W. B. (1963a). Circadian rhythm in rat pineal serotonin and its modifications by estrous cycle and photoperiod. Gen. Comp. Endocrinol. 3, 473–479.

    Article  CAS  Google Scholar 

  • Quay, W. B. (1963b). Differential extraction for the spectrophotofluorometric measurement of diverse 5-hydroxy- and 5-methoxyindoles. Anal. Biochem. 5, 51–59.

    Article  PubMed  CAS  Google Scholar 

  • Quay, W. B. (1964). Circadian and estrous rhythm in pineal melatonin and 5-hydroxyindole-3-acetic acid. Proc. Soc. Exp. Biol. Med. 115, 710–713.

    PubMed  CAS  Google Scholar 

  • Quay, W. B., and Halevy, A. (1962). Experimental modification of the rat pineal’s content of serotonin and related indoleamines. Physiol. Zool. 35, 1–7.

    CAS  Google Scholar 

  • Ralph, C. L., Mull, D., Lynch, H. J., and Hedlund, L. (1971). A melatonin rhythm persists in rat pineals in darkness. Endocrinology 89, 1361–1366.

    Article  PubMed  CAS  Google Scholar 

  • Ramaley, J. A. (1973). The development of daily changes in serum corticosterone in pre-weanling rats. Steroids 21, 433–442.

    Article  PubMed  CAS  Google Scholar 

  • Reiter, R. J. (1968a). The pineal gland and gonadal development in male rats and hamsters. Fertil. Steril. 19, 1009–1017.

    PubMed  CAS  Google Scholar 

  • Reiter, R. J. (1968b). Pineal-gonadal relationships in male rodents. In: Progress in Endocrinology (Gual, C., ed.), pp. 631–636, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Reiter, R. J. (1969). Pineal function in long term blinded male and female golden hamsters. Gen. Comp. Endocrinol. 12, 460–468.

    Article  PubMed  CAS  Google Scholar 

  • Reiter, R. J. (1972a). The role of the pineal in reproduction. In: Reproductive Biology (Balin, H., and Glasser, S., eds.), pp. 71–114, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Reiter, R. J. (1972b). Surgical procedures involving the pineal gland which prevent gonadal degeneration in adult male hamsters. Ann. Endocrinol. 33, 571–582.

    CAS  Google Scholar 

  • Reiter, R. J. (1972c). Evidence for refractoriness of the pituitarygonadal axis to the pineal gland in golden hamsters and its possible implications in annual reproductive rhythms. Anat. Rec. 173, 365–371.

    Article  PubMed  CAS  Google Scholar 

  • Reiter, R. J. (1973a). Comparative physioloay: pineal gland. Ann. Rev. Physiol. 35, 305–328.

    Article  CAS  Google Scholar 

  • Reiter, R. J. (1973b). Pineal control of a seasonal reproductive rhythm in male golden hamsters exposed to natural daylight and temperature. Endocrinology 92, 423–430.

    Article  PubMed  CAS  Google Scholar 

  • Reiter, R. J. (1974a). Effect of light and the pineal on gonadotropins: some theoretical considerations. In: Biochemistry and Physiology of the Pineal Gland (Klein, D. C., ed.), Spectrum Publ. Co., New York, in press.

    Google Scholar 

  • Reiter, R. J. (1974b). Influence of pinealectomy on the breeding capability of hamsters maintained under natural photoperiodic and temperature conditions. Neuroendocrinology, in press.

    Google Scholar 

  • Reiter, R. J., and Sorrentino, S., Jr. (1971). Inhibition of luteinizing hormone release and ovulation in PMS-treated rats by peripherally administered melatonin. Contraception 4, 385–392.

    Article  CAS  Google Scholar 

  • Reiter, R. J., Sorrentino, S., Jr., and Ellison, N. M. (1970). Interaction of photic and olfactory stimuli in mediating pineal-induced gonadal regression in adult female rats. Gen. Comp. Endocrinol. 15, 326–333.

    Article  PubMed  CAS  Google Scholar 

  • Reiter, R. J., Sorrentino, S., Jr., Ralph, C. L., Lynch, H. J., Mull, D., and Jarrow, E. (1971). Some endocrine effects of blinding and anosmia in adult male rats with observations on pineal melatonin. Endocrinology 88, 895–900.

    Article  PubMed  CAS  Google Scholar 

  • Reiter, R. J., Vaughan, M. K., Vaughan, G. M., Sorrentino, S., Jr., and Donofrio, R. J. (1974). The pineal gland as an organ of internal secretion. In: Frontiers of Pineal Physiology (Altschule, M. D., ed.), Harvard University Press, Cambridge, in press.

    Google Scholar 

  • Rønnekleiv, O. K., Krulich, L., and McCann, S. M. (1973). An early morning surge of prolactin in the male rat and its abolition by pinealectomy. Endocrinology 92, 1339–1342.

    Article  PubMed  Google Scholar 

  • Rust, C. C., and Meyer, R. K. (1969). Hair color, molt, and testes size in male, short-tailed weasels treated with melatonin. Science 165, 912–922.

    Article  Google Scholar 

  • Sassin, J. F., Frantz, A. G., Weitzman, E. D., and Kapen, S. (1972). Human prolactin: 24-hour pattern with increased release during sleep. Science 177, 1205–1207.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, N. B. (1970). Control of rhythmic secretion of gonadotropins. In: The Hypothalamus (Martini, L., Motta, M., and Fraschini, F., eds.), pp. 515–528, Academic Press, New York.

    Google Scholar 

  • Schwartz, N. B., and McCormack, C. E. (1972). Reproduction: gonadal function and its regulation. Ann. Rev. Physiol. 34, 425–472.

    Article  CAS  Google Scholar 

  • Simonovic, I., Tima, L., and Martini, L. (1971). “Hypothalamic deafferentation” and gonadotropin secretion. Experientia 27, 211–212.

    Article  PubMed  CAS  Google Scholar 

  • Smit-Vis, J. H. (1972). The effect of pinealectomy and of testosterone administration on the occurrence of hibernation in adult male golden hamsters. Acta Morph. Neerl. Scand. 10, 269–282.

    CAS  Google Scholar 

  • Smit-Vis, J. H., and Akkerman-Bellaart, M. A. (1967). Spermiogenesis in hibernating golden hamsters. Experientia 23, 844–845.

    Article  PubMed  CAS  Google Scholar 

  • Snyder, S. H., Axelrod, J., and Zweig, M. (1967). Circadian rhythm in the serotonin content of the rat pineal gland: regulating factors. J. Pharmacol. Exp. Therap. 158, 206–213.

    CAS  Google Scholar 

  • Sorrentino, S., Jr., and Reiter, R. J. (1970). Pineal-induced alteration of estrous cycles in blinded hamsters. Gen. Comp. Endocrinol. 15, 39–42.

    Article  PubMed  Google Scholar 

  • Sorrentino, S., Jr., Reiter, R. J., and Schalch, D. S. (1971a). Hypotrophic reproductive organs and normal growth in male rats treated with melatonin. J. Endocrinol. 51, 213–214.

    Article  CAS  Google Scholar 

  • Sorrentino, S., Jr., Schalch, D. S., and Reiter, R. J. (1971b). Environmental control of growth hormone and growth. In: Growth and Growth Hormone (Pecile, A., and Muller, E. E., eds.), pp. 330–348, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Thieblot, L. (1965). Physiology of the pineal body. Prog. Brain Res. 10, 479–488.

    Article  PubMed  CAS  Google Scholar 

  • Thieblot, L., Alassimare, A., and Blaise, S. (1966). Etude chromatographique et électrophorétique du facteur antigonadotrope de la glande pinéale. Ann. Endocrinol;. 27, 861–866.

    CAS  Google Scholar 

  • Thieblot, L., and Blaise, S. (1966). Etude biochimique du principe pinéal antigonadotrope. Probl. Actuels. Endocrinol. Nutr. 10, 257–275.

    PubMed  CAS  Google Scholar 

  • Thieblot, L., and Menigot, M. (1971). Acquisitions récentes sur le facteur antigonadotrope de la glande pinéale. J. Neurovisc. Rel., Suppl. X, 153–159.

    Google Scholar 

  • Turner, W. (1888). The pineal body (epiphysis cerebri) in the brain of the walrus and seals. J. Anat. Physiol. 22, 300–303.

    PubMed  CAS  Google Scholar 

  • Vaughan, M. K., Benson, B., Norris, J. T., and Vaughan, G. M. (1971). Inhibition of compensatory ovarian hypertrophy in mice by melatonin, 5-hydroxytryptamine and pineal powder. J. Endocrinol. 50, 171–175.

    Article  PubMed  CAS  Google Scholar 

  • Vaughan, M. K., and Klein, D. C. (1973). Effect of arginine vasotocin on gonadal stimulation induced by exogenous or endogenous gonadotrophin. Amer. Zoologist 13, 1288 (Abstract).

    Google Scholar 

  • Vaughan, M. K., Reiter, R. J., Vaughan, G. M., Bigelow, L., and Altschule, M. D. (1972). Inhibition of compensatory ovarian hypertrophy in the mouse and vole: a comparison of Altschule’s pineal extract, pineal indoles, vasopressin and oxytocin. Gen. Comp. Endocrinol. 18, 372–377.

    Article  PubMed  CAS  Google Scholar 

  • Vlahakes, G., and Wurtman, R. J. (1972). A Mg2+ dependent hydroxyindole-O-methyltransferase in the rat Harderian gland. Biochim. Biophys. Acta, 261, 194–198.

    Article  PubMed  CAS  Google Scholar 

  • Watzka, M., and Voss, H. (1967). Verqleichende histologische Studien an der Zirbel der Vögel. Verh. Anat. Ges. 120, 177–183.

    Google Scholar 

  • Weiss, B., and Costa, E. (1967). Effect of denervation and environmental lighting on the norepinephrine reduced activation of adenyl cyclase of the rat pineal aland. Fed. Proc. 26, 765 (Abstract).

    Google Scholar 

  • Weiss, B., and Crayton, J. (1970). Gonadal hormones as regulators of pineal adenyl cyclase activity. Endocrinology 87, 527–533.

    Article  PubMed  CAS  Google Scholar 

  • Weissbach, H., Redfield, B. G., and Axelrod, J. (1960). Biosynthesis of melatonin: enzymatic conversion of serotonin to N-acetylserotonin. Biochim. Biophys. Acta 43, 352–353.

    Article  PubMed  CAS  Google Scholar 

  • Wurtman, R. J., and Axelrod, J. (1966). A 24-hour rhythm in the content of norepinephrine in the pineal and salivary glands of the rat. Life Sci. 5, 665–669.

    Article  PubMed  CAS  Google Scholar 

  • Wurtman, R. J., Axelrod, J., and Chu, E. W. (1963). Melatonin, a pineal substance: effect on the rat ovary. Science 141, 277–278.

    Article  PubMed  CAS  Google Scholar 

  • Wurtman, R. J., Axelrod, J., and Fischer, J. E. (1964). Melatonin synthesis in the pineal gland: effect of light mediated by the sympathetic nervous system. Science 143, 1329–1330.

    Article  Google Scholar 

  • Wurtman, R. J., Axelrod, J., and Phillips, L. S. (1963). Melatonin synthesis in the pineal gland: control by light. Science 142, 1071–1072.

    Article  PubMed  CAS  Google Scholar 

  • Wurtman, R. J., Axelrod, J., Sedvall, G., and Moore, R. Y. (1967). Photic and neural control of the 24-hour norepinephrine rhythm in the rat pineal gland. J. Pharmacol. Exp. Therap. 157, 487–492.

    CAS  Google Scholar 

  • Wurtman, R. J., Axelrod, J., Snyder, S. H., and Chu, W. W. (1965). Changes of the enzymatic synthesis of melatonin in the pineal during the estrous cycle. Endocrinology 76, 798–800.

    Article  PubMed  CAS  Google Scholar 

  • Ying, S. -Y., and Greep, R. O. (1973). Inhibition of ovulation by melatonin in the cyclic rat. Endocrinology 92, 333–335.

    Article  PubMed  CAS  Google Scholar 

  • Zieher, L. M., and Pellegrino de Iraldi, A. (1966). Central control of the noradrenaline content in the rat pineal and submaxillary gland. Life Sci. 5, 155–161.

    Article  PubMed  CAS  Google Scholar 

Discussion References

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1975 Plenum Press, New York

About this chapter

Cite this chapter

Reiter, R.J. (1975). Endocrine Rhythms Associated with Pineal Gland Function. In: Hedlund, L.W., Franz, J.M., Kenny, A.D. (eds) Biological Rhythms and Endocrine Function. Advances in Experimental Medicine and Biology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8715-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8715-2_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8717-6

  • Online ISBN: 978-1-4684-8715-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics