Abstract
Achondroplasia is the most common of the inherited bone dysplasias in man. It is well defined clinically, radiographically and genetically (1, 2). Although its pathogenesis is thought to involve defective endochondral ossification, the specific way in which this occurs is not known. Previous studies of the growth plate in achondroplasia have suggested that the architecture of the growth plate may be mildly abnormal and that there may be abnormalities of extracellular matrix constituents including cartilage collagen and proteoglycan (3, 4). To further explore this issue we have investigated growth plate tissue from 7 patients with heterozygous achondroplasia and 2 patients with homozygous achondroplasia by a combination of biochemical, immunohistochemical, morphometric and ultrastructural methods.
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© 1988 Plenum Press, New York
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Horton, W.A., Hood, O.J., Machado, M.A., Campbell, D. (1988). Growth Plate Cartilage Studies in Achondroplasia. In: Nicoletti, B., Kopits, S.E., Ascani, E., McKusick, V.A., Dryburgh, S.C. (eds) Human Achondroplasia. Basic Life Sciences, vol 48. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8712-1_11
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DOI: https://doi.org/10.1007/978-1-4684-8712-1_11
Publisher Name: Springer, Boston, MA
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