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Application of Mass Spectrometry to Forensic Toxicology

I. Acidic and Neutral Drugs

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Developments in Applied Spectroscopy

Part of the book series: Developments in Applied Spectroscopy ((DAIS,volume 7a))

Abstract

The use of mass spectrometry in forensic toxicology to detect acidic and neutral drugs is discussed. The speed and versatility of the mass spectrometer make it suitable for detecting these drugs and their metabolites. The advantages of using this method as an analytical tool include the ability to identify drugs for which good chemical tests are lacking, the use of small samples, and the saving of time by direct determination of acidic and neutral fractions without further purification. The mass spectra of these drugs can be obtained at volatilization temperatures below those necessary for normally-occurring interfering tissue impurities.

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References

  1. C. J. Umberger, in: Legal Medicine, Pathology and Toxicology, T. A. Gonzales, M. Vance, M. Helpern, and C. J. Umberger, eds., Appleton-Century-Crofts, New York (1954),pp. 1127, 1153, 1128.

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  3. H. Budzikiewicz, C. Djerassi, and D. H. Williams, Interpretation of Mass Spectra of Organic Compounds, Holden-Day, San Francisco (1964).

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Author information

Authors and Affiliations

  1. Department of Forensic Medicine, New York University Medical Center, New York, New York, USA

    Paritosh K. De & Charles J. Umberger

  2. Department of Toxicology, Office of Chief Medical Examiner, New York, New York, USA

    Paritosh K. De & Charles J. Umberger

Authors
  1. Paritosh K. De
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  2. Charles J. Umberger
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Editor information

Editors and Affiliations

  1. Research Laboratories, Illinois Institute of Technology, Chicago, Illinois, USA

    E. L. Grove

  2. College of Pharmacy, University of Illinois, Chicago, Illinois, USA

    Alfred J. Perkins

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© 1969 Chicago Section of the Society for Applied Spectroscopy

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De, P.K., Umberger, C.J. (1969). Application of Mass Spectrometry to Forensic Toxicology. In: Grove, E.L., Perkins, A.J. (eds) Developments in Applied Spectroscopy. Developments in Applied Spectroscopy, vol 7a. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8700-8_18

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  • DOI: https://doi.org/10.1007/978-1-4684-8700-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8702-2

  • Online ISBN: 978-1-4684-8700-8

  • eBook Packages: Springer Book Archive

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