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Cholinergic Mechanisms pp 109–118Cite as

Multiple Mechanisms in Ganglionic Transmission

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 25))

Abstract

Transmission in sympathetic ganglia is complex; in addition to the fast excitatory postsynaptic potential (f-epsp) which represents a primary synaptic pathway of the ganglia, there are several slow synaptic potentials, both excitatory and inhibitory that may serve to modulate the primary transmission; these include slow excitatory and late slow excitatory postsynaptic potentials (s-epsp and ls-epsp respectively) and slow inhibitory postsynaptic potential (s-ipsp) (3,14,18,19,23). Ganglionic transmission is also a multitransmitter phenomenon. There is now evidence that in addition to the classical transmitter, acetylcholine (ACh), a number of other substances may serve as transmitters or modulators in the ganglia. In recent years, immunohistofluorescent techniques have demonstrated the presence of various peptides, such as substance P or a related peptide, and enkephalins or enkephalin-like substances, in peripheral media (cf. 28). We present here some of our findings indicating that substance P and enkephalins may indeed participate in ganglionic transmission.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Loyola University Stritch School of Medicine, 60153, Maywood, Illinois, USA

    N. J. Dun & A. G. Karczmar

Authors
  1. N. J. Dun
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  2. A. G. Karczmar
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Editor information

Editors and Affiliations

  1. Institute of Pharmacology, University of Florence, Florence, Italy

    Giancarlo Pepeu

  2. Mario Negri Institute for Pharmacological Research, Milan, Italy

    Herbert Ladinsky

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© 1981 Plenum Press, New York

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Dun, N.J., Karczmar, A.G. (1981). Multiple Mechanisms in Ganglionic Transmission. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_9

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  • DOI: https://doi.org/10.1007/978-1-4684-8643-8_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8645-2

  • Online ISBN: 978-1-4684-8643-8

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