Abstract
The availability of choline (Ch) in the microenvironment of the nerve terminal and its transport across the neuronal membrane may play a significant role in the dynamic regulation of acetylcholine (ACh) metabolism. However, the precise nature of, or factors involved in, the regulatory processes have not been unequivocally determined. In particular, relatively little attention has been focussed on the possibility that the mechanisms regulating the metabolism of ACh can be modified or directly influenced by the state of neuronal activity. Plasticity, the ability to alter or adapt with the immediate environment, is characteristic of numerous biological systems. Hence, it is possible that the regulatory mechanisms controlling the metabolism of ACh may vary according to the demands imposed on the neuron. In order to characterize the nature of the regulatory process(es) and elucidate the determinant effects of the availability and transport of Ch on the metabolism of ACh, we have taken into account the physiological status of the neuron. Consideration of both the supply to and the demand of the system for Ch will undoubtedly clarify the relationship between neuronal activity and possible regulatory mechanisms.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ansell, G.B. and Spanner, S. (1975): In Cholinergic Mechanisms, (ed) P.G. Waser, Raven Press, New York, pp. 117–129.
Barker, L.A. (1976): In Biology of Cholinergic Function,(eds) A.M. Goldberg and I. Hanin, Raven Press, New York, pp. 203- 238.
Barker, L.A. and Mittag, T. (1975): J. Pharmacol. Exp. Ther. 192:86–94.
Bierkamper, G.G. and Goldberg, A.M. (1979): In Nutrition and the Brain, Vol. 5 (eds) A. Barbeau, J. H. Growdon and R. J. Wurtman, Raven Press, New York, pp. 243–251.
Birks, R. and Macintosh, F.C. (1961); Canad. J, Biochem. Physiol. 39:787–827.
Browning, E.T. (1976): In Biology of Cholinergic Function, (eds) A. M. Goldberg and I. Hanin, Raven Press, New York, pp. 187–201.
Browning, E.T. and Schulman, M.P. (1968): J. Neurochem. 15:1391–1405.
Carroll, P.T. and Goldberg, A.M. (1975): J. Neurochem. 25: 523–527.
Choi, R.L., Freeman, J.J. and Jenden, D.J. (1975): J. Neurochem. 24:735–741.
Cohen, E. and Wurtman, R.J. (1975): Life Sci. 16:1095–1102.
Collier, B. and Macintosh, F.C. (1969); Canad. J. Physiol. Pharmacol. 47:127–135.
Dowdall, M.J. and Simon, E.J. (1973): J. Neurochem. 21:969–982
Dross, K. and Kewitz, H. (1972): Naun.-Schmid. Arch. Pharmacol Exp. Pathol. 274:91–106.
Dudar, J.D. and Szerb, J.C. (1969): J. Physiol. 203:741–762.
Eckernas, S.A., Sahlstrom, L. and Aquilonius, S.M. (1977): Acta Physiol. Scand. 101:404–410.
Freeman, J.J., Choi, R.L. and Jenden, D.J. (1975): J. Neurochem. 24:729–734.
Guyenet, P., Lefresne, P., Rossier, J., Beaujouan, J.C. and Glowinski, J. (1973): Molec. Pharmacol. 9:630–639.
Haga, T. and Noda, H. (1973): Biochem. Biophys, Acta 291: 564–575.
Hanin, I. and Schuberth, J. (1974): J. Neurochem. 23:819–824.
Hanin, I., Massarelli, R. and Costa, E. (1972): Adv. Biochem. Pharmacol. 6:181–203.
Haubrich, D.R., Wedeking, P.W. and Wang, P.F.L. (1974): Life Sci. 14:921–927.
Haubrich, D.R., Wang, P.F.L., Clody, D.E. and Wedeking, P.W.(1975):Life Sci. 17:975–980.
Haubrich, D.R., Wang, P.F.L., Chippendale, T. and Procter. E.(1976):J. Neurochem. 27:1305–1313.
Holmstedt, B. (1967): Ann. N.Y. Acad. Sci. 144:433–458.
Jenden, D.J., Jope, R.S. and Weiler, M.H. (1976): Science 194:635–637.
Jope, R.S. and Jenden, D.J. (1977): Life Sci. 20:1389–1393.
Kewitz, H., Dross, K. and Pleul, O. (1973): In Central Neryous System: Studies on Metabolic Regulation and Function, (eds) E. Genazzani and H. Herken, Springer-Verlag, New York, pp. 21–32
Ksiezak, H. and Goldberg, A.M. (1979): Neurosci. Abst. 5:591.
Kuhar, M.J. and Zarbin, M.A. (1978): J. Neurochem. 31:251–256.
Lovat, S., Millington, W. and Collier, B. (1978): Proc. Canad. Fed. Biol. Sci. 21:2.
Lundholm, B. and Sparf, B. (1975): Eur. J. Pharmacol. 32,:287–292.
Masland, R.H. and Livingstone, C.J. (1976): J. Neuro Physiol. 39:1210–1219.
Moleman, P. and Bruinvels, J. (1979); Nature 281:686–687.
Murrin, L.C., DeHaven, R.N. and Kuhar, M.J. (1977): J. Neurochem. 29: 681–687.
Pedata, F., Wieraszko, A. and Pepeu, G. (1977); Pharmacol. Res. Commun. 9:755–761.
Perry, W.L.M. (1953): J. Physiol. 119:439–454.
Potter, L.T. (1970): J. Physiol. 206:145–166.
Racagni, G., Trabucchi, M. and Cheney, D.L. (1975): Naun,-Schmid. Arch. Pharmacol. 290:99–105.
Schuberth, J., Sparf, B. and Sundwall, A. (1969): J. Neurochem, 16:695–700.
Schuberth, J., Sparf, B. and Sundwall, A, (1970): J, Neurochem. 17: 461–468.
Sherman, K.A., Hanin, I. and Zigmond, M.J. (1978); J. Pharmacol Exp. Ther. 206:677–686.
Simon, J.R., Atweh, S. and Kuhar, M.J. (1976): J. Neurochem. 26:909–922.
Suszkiw, J.B., Beach, R.L. and Pilar, G.R. (1976): J. Neurochem. 26:1123–1131.
Szerb, J.C., Malik, H. and Hunter, E.G. (1970): Canad. J. Physiol. Pharmacol. 48:780–790.
Trommer, B.A., Schmidt, D.E. and Wecker, L, (1980): Fed. Proc. 39:412.
Wecker, L. and Dettbarn, W-D. (1979): J. Neurochem. 32:961–967.
Wecker, L. and Schmidt, D.E. (1979): Life Sci. 25:375–384.
Wecker, L. and Schmidt, D.E. (1980): Brain Res. 184:234–238.
Wecker, L., Dettbarn, W -D. and Schmidt, D.E. (1978); Science 199:86–87.
Weiler, M.H., Jope, R.S. and Jenden, D.J. (1978): J. Neurochem. 31:789–796.
Yamamura, H.I. and Snyder, S.H. (1973): J. Neurochem. 21: 1355–1374.
Yavin, E. (1976): J. Biol. Chem. 251:1392–1397
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Wecker, L., Goldberg, A.M. (1981). Regulation of Acetylcholine Release During Increased Neuronal Activity. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_45
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8643-8_45
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8645-2
Online ISBN: 978-1-4684-8643-8
eBook Packages: Springer Book Archive