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Cholinergic Mechanisms pp 451–461Cite as

Regulation of Acetylcholine Release During Increased Neuronal Activity

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 25))

Abstract

The availability of choline (Ch) in the microenvironment of the nerve terminal and its transport across the neuronal membrane may play a significant role in the dynamic regulation of acetylcholine (ACh) metabolism. However, the precise nature of, or factors involved in, the regulatory processes have not been unequivocally determined. In particular, relatively little attention has been focussed on the possibility that the mechanisms regulating the metabolism of ACh can be modified or directly influenced by the state of neuronal activity. Plasticity, the ability to alter or adapt with the immediate environment, is characteristic of numerous biological systems. Hence, it is possible that the regulatory mechanisms controlling the metabolism of ACh may vary according to the demands imposed on the neuron. In order to characterize the nature of the regulatory process(es) and elucidate the determinant effects of the availability and transport of Ch on the metabolism of ACh, we have taken into account the physiological status of the neuron. Consideration of both the supply to and the demand of the system for Ch will undoubtedly clarify the relationship between neuronal activity and possible regulatory mechanisms.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Louisiana State University Medical Center, 70112, New Orleans, Louisiana, USA

    L. Wecker

  2. Department of Environmental Health Sciences Division of Toxicology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, 21205, USA

    A. M. Goldberg

Authors
  1. L. Wecker
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  2. A. M. Goldberg
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Editor information

Editors and Affiliations

  1. Institute of Pharmacology, University of Florence, Florence, Italy

    Giancarlo Pepeu

  2. Mario Negri Institute for Pharmacological Research, Milan, Italy

    Herbert Ladinsky

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© 1981 Plenum Press, New York

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Wecker, L., Goldberg, A.M. (1981). Regulation of Acetylcholine Release During Increased Neuronal Activity. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_45

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  • DOI: https://doi.org/10.1007/978-1-4684-8643-8_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8645-2

  • Online ISBN: 978-1-4684-8643-8

  • eBook Packages: Springer Book Archive

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