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Acetylcholine Biosynthesis in Developing Cholinergic Synapses

  • Chapter
Cholinergic Mechanisms

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 25))

Abstract

In contrast to in vitro conditions synapse formation in situ represents a long term process (16) consisting of consecutive steps of complex structural and biochemical modifications. On a chronological scale, synaptogenesis occurs not only during part of the embryonic phase but also during the period following birth or hatching. Recent studies have shown that in the avian peripheral nervous system the process of synaptic growth may continue throughout adult life (30). In the present study chick ciliary ganglia and their target organ (the iris) provides a useful model for investigating the process of synapse formation and growth (Fig. 1). For a comparison, the development of synapses in sympathetic ganglia (lumbar) was examined in a parallel study (14). The possibility of examining simultaneously cell bodies and terminals in the same group of cells belonging to a small (3000 cells) and well defined cholinergic population, represents a unique feature of this preparation (18). In this model, changes in biochemical parameters related to acetylcholine (ACh) metabolism can be correlated step by step to neurotransmission and morphology (15).

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Author information

Authors and Affiliations

  1. Laboratory of Neuropsychopharmacology, Department of Biobehavioral Sciences, University of Connecticut Storrs, Connecticut, 06268, USA

    E. Giacobini & M. Marchi

Authors
  1. E. Giacobini
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  2. M. Marchi
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Editor information

Editors and Affiliations

  1. Institute of Pharmacology, University of Florence, Florence, Italy

    Giancarlo Pepeu

  2. Mario Negri Institute for Pharmacological Research, Milan, Italy

    Herbert Ladinsky

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© 1981 Plenum Press, New York

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Giacobini, E., Marchi, M. (1981). Acetylcholine Biosynthesis in Developing Cholinergic Synapses. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_1

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  • DOI: https://doi.org/10.1007/978-1-4684-8643-8_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8645-2

  • Online ISBN: 978-1-4684-8643-8

  • eBook Packages: Springer Book Archive

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