Skip to main content

Studies of the Secretion and the Metabolism of Steroid Conjugates: Synthesis, Analysis, and Use of Doubly Labeled Compounds

  • Chapter
Advances in Tracer Methodology

Abstract

The conjugated steroids, namely, the hemi-esters of sulfuric acid (sulfates, S) and the β-D-glucopyranuronosides (glucuronides, G) were considered as detoxication forms of the hormones and their metabolites. Recently, the adrenal cortical secretion of dehydroisoandrosterone sulfate (DS) [1] and the metabolic transformation of this compound into other compounds and especially other steroid conjugates were shown, and renewed the interest in their study [2,3]. Some problems concerning the synthesis and analysis of steroid conjugates and the application of the methods so described to biochemical research will be considered.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baulieu, E.E., Compt. Rend. Acad. Sci. 251: 1421 (1960).

    CAS  Google Scholar 

  2. Roberts, K.D., Van de Wiele, R.L., and Lieberman, S., J. Biol. Chem. 236: 2213 (1961).

    PubMed  CAS  Google Scholar 

  3. Baulieu, E.E., Corpéchot, C., Dray, F., Emiliozzi, R.,Lebeau, M.C., Mauvais-Jarvis, P., and Robel, P., in Pincus, G. (editor), Recent Progress in Hormone Research 21:411 (1965).

    Google Scholar 

  4. Sobel, A.E., and Sperri, P.E., J. Am. Chem. Soc. 64: 361 (1942).

    Article  CAS  Google Scholar 

  5. Baulieu, E.E., and Emiliozzi, R., Bull. Soc. Chim. Biol. 44: 823 (1962).

    CAS  Google Scholar 

  6. Baulieu, E.E., Corpéchot, C., and Emiliozzi, R., Steroids 2: 429 (1963).

    Article  CAS  Google Scholar 

  7. Goebel, W.F., and Sabers, F.H., J. Biol. Chem. 111: 347 (1935).

    CAS  Google Scholar 

  8. Robel, P., Emiliozzi, R., and Baulieu, E.E., J. Biol. Chem. 241: 20 (1966).

    PubMed  CAS  Google Scholar 

  9. Robel, P., Emiliozzi, R., and Baulieu, E.E., Compt. Rend. Acad. Sci. 261:4886 (1965); J. Biol. Chem. (in press).

    Google Scholar 

  10. Wengle, B., and Boström, H., Acta Chem. Scand. 16: 502 (1962).

    Article  CAS  Google Scholar 

  11. Edwards, R. W. H., Kellie, A.E., and Wade, A. P., Mem. Soc. Endocrinol. 2: 53 (1953).

    Google Scholar 

  12. MacKenna, J., and Norymberski, K. J., Biochem. J. 76: 60 (1960).

    Google Scholar 

  13. Crépy, O., Jayle, M.F., and Meslin, R., Acta Endocrinol. 24: 233 (1957).

    Article  Google Scholar 

  14. Siiteri, P., Ph.D. dissertation, Columbia University (1962).

    Google Scholar 

  15. Siiteri, P., Steroids 2: 687 (1963).

    Article  CAS  Google Scholar 

  16. Schneider, J. J., and Lewbart, M. L., Recent Progress in Hormone Research, Vol. 15, Academic Press, New York, 1959, p. 201.

    Google Scholar 

  17. Cavina, G., Bull. Soc. Ital. Biol. Sper. 31: 1666 (1955).

    CAS  Google Scholar 

  18. Calvin, H.I., Van de Wiele, R.L., and Lieberman, S., Biochemistry 2: 648 (1963).

    Article  PubMed  CAS  Google Scholar 

  19. Roberts, K. D., Bandi, L., Calvin, H. I., Drucker, W. D., and Lieberman, S., Biochemistry 3: 1983 (1964).

    Article  PubMed  CAS  Google Scholar 

  20. Sandberg, E., Gurpide, E., and Lieberman, S., Biochemistry 3: 1256 (1964).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1966 New England Nuclear Corporation

About this chapter

Cite this chapter

Baulieu, E.E., Emiliozzi, R., Lebeau, M.C., Corpéchot, C., Robel, P. (1966). Studies of the Secretion and the Metabolism of Steroid Conjugates: Synthesis, Analysis, and Use of Doubly Labeled Compounds. In: Rothchild, S. (eds) Advances in Tracer Methodology. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-8625-4_30

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8625-4_30

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-8627-8

  • Online ISBN: 978-1-4684-8625-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics