Diffusion of Radioactively Labeled Molecules in Heart Muscle
In the description of cellular shape and dimensions by electron microscopy an important limitation has been the artifact and distortion introduced by death, fixation, dehydration, sectioning, and staining. It therefore seemed desirable to approach the study of tissue ultrastructure by less destructive methods, suitable for use in intact tissues. This paper describes the results of measurements on the diffusion of radioactively labeled molecules in cat heart muscle. Such measurements yield a more precise definition of cellular and extracellular volume, as well as of the approximate dimensions of the channels available for extracellular diffusion.
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