Skip to main content
SpringerLink
Log in

Factor VIII and Antithrombin III in Atherosclerosis Obliterans of the Lower Limbs

  • Chapter
Book cover Thrombosis and Cardiovascular Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 164))

Abstract

In the multifactorial pathogenesis of atherosclerosis (the W.H.O. gives a list of about forty risk factors) recent acquisitions have allowed to determine in part the role carried out by the term “haemocoagulative disorders” (90) showing the possible connections between haematic components of haemocoagulation and vascular wall that up to now have been only hypothesised.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. U. Abilgaard, Inhibition of the thrombin-fibrinogen reaction by antithrombin III studied by N-terminal analysis. Scand. J. Clin. Lab. Inv. 20:205 (1967).

    Google Scholar 

  2. U. Abilgaard, Inhibition of the thrombin-fibrinogen reaction by alpha 2-macroglobulin, studied by N-terminal analysis. Thromb. Diath. Haemorrh. 21:173 (1968).

    Google Scholar 

  3. L.O. Almer, I.M. Nilsson, On fibrinolysis in diabetes mellitus. Acta Med. Scand. 198:101 (1975).

    Article  PubMed  CAS  Google Scholar 

  4. H.N. Antoniades, C.D. Scher, Growth factor derived from human serum, human platelets and human pituitary: properties and immunological cross reactivity. J. Natl. Cancer Institute p. 137 (1978).

    Google Scholar 

  5. G. Avellone, V. Mandalà, G. Raneli, Coagulazione, aggregazione piastrinica, fibrinolisi in pazienti affetti da arteriopatia ad evoluzione obliterante degli arti inferiori. In: Di Matteo G. & Pola P. (eds.): Atti I Congresso Nazionale della Società Italiana di Patologia Vasculare, p. 231, ERRE.DI.E., Roma, 1979.

    Google Scholar 

  6. G. Avellone, S. Novo, G. Davì, G. Abruzzese, Plasmatic fibrinogen, plasminogen and antithrombin III levels in atherosclerotic patients. In: Strano A. (ed.): Proceedings of European Symposium on advances in coagulation, fibrinolysis, platelet aggregation and atherosclerosis, p. 183, C.E.P.I., Roma, 1978.

    Google Scholar 

  7. G. Avellone, V. Mandalà, F.P. Riolo, A. Pinto, Antithrombin III in patients with atherosclerotic vascular disease. Abstracts of: First International “Colloquy” of Angiology, p. 271, Firenze, 1979.

    Google Scholar 

  8. N.U. Bang, M.L. Chang, Soluble Fibrin complexes. Sem. Thromb. Haemostas. 1:91 (1974).

    CAS  Google Scholar 

  9. D. Bensoussan, S. Levi-Toledano, P. Passa, Platelet hyperaggregation in increased plasma level of von Willebrand factor in diabetics with retinopathy. Diabetologia 11:307 (1975).

    Article  PubMed  CAS  Google Scholar 

  10. R. Biggs, K.W.E. Denson, N. Alkman, R. Barrett, M. Hadden, Antithrombin III, antifactor Xa and heparin. Br. J. Haematol. 19:283 (1970).

    Article  PubMed  CAS  Google Scholar 

  11. R. Biggs, The absorption of human F. VIII neutralising antibody by factor VIII. Br. J. Haematol. 26:259–268 (1974).

    Article  PubMed  CAS  Google Scholar 

  12. T.K. Bills, J.B. Smith, M.J. Silver, Metabolism of (14C) arachidonic acid by human platelets. Biochim. Biophys. Acta 124: 303 (1976).

    Google Scholar 

  13. A.L. Bloom, J.C. Giddings, G.R. Peake, Low molecular weight factor VIII. Lancet 1:661–662 (1973).

    Article  PubMed  CAS  Google Scholar 

  14. A.L. Bloom, G.R. Peake, J.C. Giddings, The presence and reactions of high and lower molecular weight procoagulant F.VIII in the plasma of patients with von Willebrand disease after treatment; significance for a structural hypothesis for F.VIII. Thromb. Res. 3:389–404 (1973).

    Article  Google Scholar 

  15. A.L. Bloom, S.C. Giddings, C.J. Wilks, Factor VIII on vascular intima: possible importance in hemostasis and thrombosis. Nature. New Biology 241:217 (1973).

    Article  PubMed  CAS  Google Scholar 

  16. B. Boneu, M. Abbal, J. Plante, R. Bierme, Factor VIII complex and endothelial damage. Lancet 1:1430 (1975).

    Article  PubMed  CAS  Google Scholar 

  17. B. Boneu, D. Durand, F. Counillan, J.P. Charlet, R. Bierme, J.M. Sue, Increased level of factor VIII complex in severe arterial hypertension. Haemostasis 7:332 (1978).

    PubMed  CAS  Google Scholar 

  18. B.N. Bouma, J.M. Hordijk-Hoss, S. De Graaf, J.J. Sixma, J.A. Van Mourik, Presence of factor VIII related antigen in blood platelets of patients with von Willebrand’s disease. Nature 257:510 (1975).

    Article  PubMed  CAS  Google Scholar 

  19. C. Busch, J. Dawes, D.S. Pepper, A. Wasteson, Binding of platelet factor 4 to cultured human endothelial cells. Thrombos. Haemostas. 42:43 (1979).

    Google Scholar 

  20. C. Cavallero, Modificazioni della parete arteriosa nell’arteriosclerosi. In: Cardiología Oggi, vol. 1, p. 193, Ed. Med. Scient., Torino 1975.

    Google Scholar 

  21. A.B. Chandler, Thrombosis and the development of atherosclerosis lesion. In: Jones R. (ed.): Atherosclerosis, p. 88, Springer, New York, 1970.

    Google Scholar 

  22. A.B. Chandler, I. Chapman, L.R. Erhardt, W.C. Roberts, J.C. Schwartz, D. Sinapius, D.M. Spain, S. Sherry, P.M. Neiss, T.L. Simon, Coronary thrombosis in myocardial infarction. Report of a workshop on the role of coronary thrombosis in the pathogenesis of acute myocardial infarction. Am. J. Cardiol. 34:823 (1974).

    Article  PubMed  CAS  Google Scholar 

  23. P.S. Damus, M. Hicks, R.D. Rosenberg, A generalized view of heparin’s anticoagulatnt action. Nature 246:355 (1973).

    Article  PubMed  CAS  Google Scholar 

  24. M.J. Davies, N. Woolf, J.W.P. Bradley, Endothelialisation of experimentally produced mural thrombi in the pig aorta. J. Pathol. 97:589 (1969).

    Article  PubMed  CAS  Google Scholar 

  25. K.W.E. Denson, Reagents and techniques, In: The treatment of haemophilia and other clotting disorders. Ed. by R. Biggs and R.G. Macfarlane, p. 337. Blackwell Scientific Publication, Oxford 1966.

    Google Scholar 

  26. K.W.E. Denson, Standardization of methods for the determination of factor VIII. Thrombos. Diathes. Haemorrh. Suppl. 43:99 (1971).

    Google Scholar 

  27. K.W.E. Denson, G.I.C. Ingram, Antigen/biologival-activity ratio for factor VIII. Lancet, 1: 1973.

    Google Scholar 

  28. K.W.E. Denson, In: Human blood coagulation, haemostasis and thrombosis. Ed. by: Biggs R., Blackwell Scientific Publications, Oxford-Edinburgh, 1976.

    Google Scholar 

  29. M. Ekberg, I.M. Nilsson, Factor VIII and glomerulonephritis. Lancet 1: 1111 (1975).

    Article  PubMed  CAS  Google Scholar 

  30. A.P. Fletcher, N. Alkjaersig, O. Owens, G. Wolff, J.R. Smith, Blood hypercoagulability, thrombosis and acute myocardial infarction. J. Lab. Clin. Med. 78:798 (1971).

    PubMed  CAS  Google Scholar 

  31. A.P. Fletcher, N. Alkjaersig, Blood screening methods for the diagnosis of venous thrombosis. Milkbank Mem. Fund. Q. 50: 170 (1972).

    Article  Google Scholar 

  32. A. Girolami, A. Sticchi, T. Barbui, G. Bareggi, Factor VIII immunological assay. An evaluation of several methods using whole plasma. Blut. Band XXIX:309 (1974).

    Google Scholar 

  33. H.L. Goldsmith, The flow of model particles and blood cells and its relation to thrombogenesis. In: Spet T.H. (ed.): Progress in haemostasis and thrombosis. Grune and Stratton, New York, 1972.

    Google Scholar 

  34. J. Gormsen, J.D. Nielsen, L.A. Andersen, ADP-induced platelet aggregation in patients with ischemic heart disease and peripheral thrombo-atherosclerosis. Acta Med. Scand. 201: 509 (1977).

    Article  PubMed  CAS  Google Scholar 

  35. J.W. Haerem, Platelets and sudden death. In: Neri Serneri G.G., Mason, D.T. (eds.): Myocardial Infarction. Excerpta Medica, Amsterdam, p. 30, 1979.

    Google Scholar 

  36. M.D. Haust, R.H. Moore, Development of modern theories on tne pathogenesis of atherosclerosis, In: Wissler R.W., Geer J.C. (eds.): The pathogenesis of atherosclerosis, p. 1, Williams & Wilkins, Baltimora 1972.

    Google Scholar 

  37. E.J. Hershgold, A.M. Davison, M.E. Jansgen, Human F. VIII (antihemophilic factor): activation and inactivation by phospho-lipases. J. Lab. Clin. Med. 77:206 (1971).

    PubMed  CAS  Google Scholar 

  38. E.J. Hershgold, A.M. Davison, M.E. Jansgen, Isolation and some clinical properties of human F. VIII J. Lab. Clin. Med. 77: 185 (1971).

    PubMed  CAS  Google Scholar 

  39. H. Holmsen, Prostaglandin endoperoxide-thromboxane synthesis and dense granuli secretion as positive feedback loops in the propagation of platelet responses during “the basic platelet reaction”. Thromb. Haemost. 38:1030 (1977).

    PubMed  CAS  Google Scholar 

  40. P.W. Howie, C.B. Begg, D.W. Purdie, & coll. Use of coagulation tests to predict the clinical progress of pre-eclampsia. Lancet 2:323 (1976).

    Article  PubMed  CAS  Google Scholar 

  41. J. Hudson, W.T.E. McCaughy, Mural thrombosis and atherogenesis in coronary arteries and aorta. An investigation using anti-fibrin and antiplatelet sera. Atherosclerosis 19:543 (1974).

    Article  PubMed  CAS  Google Scholar 

  42. A. Huges, R.S. Tonks, The role of microemboli in the production of carditis in hypersensitivity experiments. J. Path. Bacte-riol. 77:207 (1959).

    Article  Google Scholar 

  43. E.A. Jaffe, L.W. Hoyer, R.L. Nachman, Synthesis of antiemophilic factor antigen by cultured human endothelial cells. J. Clin. Invest. 52:2757 (1973).

    Article  PubMed  CAS  Google Scholar 

  44. E.A. Jaffe, L.W. Hoyer, R.L. Nachman, Synthesis of von Willebrand factor by cultured human endothelial cells. Proc. Natl. Acad. Sci. USA, 7:190 (1974).

    Google Scholar 

  45. E.A. Jaffe, R.L. Nachman, Submit structure of factor VIII antigen synthetized by cultured human endothelial cells. J. Clin. Invest. 56:698 (1975).

    Article  PubMed  CAS  Google Scholar 

  46. E.A. Jaffe, Endothelial cells and the biology of factor VIII. Nature 296:377 (1977).

    CAS  Google Scholar 

  47. C.L. Janssen, W.M. van Leuwen, Behaviour of factors V and factor VII during the process of blood coagulation. Scand. J. Haemat. 9:531 (1972).

    Article  PubMed  CAS  Google Scholar 

  48. L. Jorgensen, T. Hovig, H.C. Roswell, J.F. Mustard, Adenosine diphosphate induced platelet aggregation and vascular injury in swine and rabbits. Am. J. Pathol. 61:161 (1970).

    PubMed  CAS  Google Scholar 

  49. L. Jorgensen, M.A. Packham, H.C. Roswell, M.R. Buchanan, J.F. Mustard, Local aortic injury caused by cannulation: increased plasma protein accumulation and thrombosis. Acta Path. Microbiol.Scand. 82:637 (1974).

    CAS  Google Scholar 

  50. K.L. Kaplan, H.L. Nossel, M. Drillings, G. Lesznik, Radioim munoassay of platelet factor 4 and beta-thromboglobulin: development and application to studies of platelet release in relation to fibrinipeptide A generation. Br. J. Haematol. 38:129 (1978).

    Article  Google Scholar 

  51. M. Kazama, T. Abe, Change of the molecular mass of fibrinogen in circulating blood, as an index of hypercoagulable states. Thromb. Res. 8:(Suppl. II) 133 (1976).

    Article  PubMed  CAS  Google Scholar 

  52. P.E.A. Kernoff, Affinity of factor VIII clotting activity for antigen detectable immunologically. Nature. New Biology 244:148 (1973).

    PubMed  CAS  Google Scholar 

  53. B.A. Kottke, M.T.R. Subbiah, Subject review pathogenesis of atherosclerosis, concepts based on animal models. Mayo Clin. Proc. 53:35 (1978).

    PubMed  CAS  Google Scholar 

  54. J.L. Lane, P. Bird, C.R. Rizza, A new assay for measurement of total progressive antithrombin. Br. J. Haematol. 30:103 (1975).

    Article  PubMed  CAS  Google Scholar 

  55. C.B. Laurell, Quantitative estimation of proteins by elettro-phoresis in agarose gel containing antibodies. Analitical Biochemistry 15:45 (1966).

    Article  CAS  Google Scholar 

  56. C.B. Laurell, Electroimmuno assay. Scand. J. Clin. Lab. Invest. 29, suppl. 124:21 (1972).

    Article  CAS  Google Scholar 

  57. E.C. Lian, R.R. Minej, D.R. Harnnes, In vitro and in vivo effects of thrombin and plasmin on human factor VIII (AHF). Am. J. Haemat. 1:481 (1976).

    Article  CAS  Google Scholar 

  58. C.A. Ludlam, J.D. Cash, Studies on the liberation of betathromboglobulin from human platelets in vitro. Brit. J. Haematol. 33:239 (1976).

    Article  CAS  Google Scholar 

  59. C.A. Ludlam, Beta-thromboglobulin. A new diagnostic tool in the diagnosis of hypercoagulability? In: Neri Serneri G.G., Prentice C.R.M. (eds.): Florence Conference on Haemostasis and Thrombosis. Academic Press, London 1977.

    Google Scholar 

  60. P.M. Mannucci, F.I. Pareti, L. Holmberg, I.M. Nilsson, Z.M. Ruggeri, Studies on the prolonged bleeding time in von Willebrand’s disease. J. Lab. Clin. Med., October, 662 (1976).

    Google Scholar 

  61. E.E. Mayne, J.M. Bridges, J.A. Weawer, Platelet adhesiveness, plasma fibrinogen and factor VIII levels in diabetes mellitus. Diabetologia. 6:436 (1970).

    Article  PubMed  CAS  Google Scholar 

  62. S. Moore, D.S. Pepper, J.D. Cash, The isolation and characterization of a platelet specific release beta-globulin: beta-thromboglobulin and the detection of antiurokinase and anti-plasmin released from thrombin aggregated washed human platelets. Bioch. Biophys. Acta 379:360 (1975).

    Article  CAS  Google Scholar 

  63. M. Moroi, N. Aoki, Inhibition of plasminogen binding to fibrin by alpha-2-plasmin inhibitor. Thromb. Res. 10:851 (1977a).

    Article  PubMed  CAS  Google Scholar 

  64. M. Moroi, N. Aoki, On the interaction of alpha-2-plasmin inhibitor and proteases. Evidence for the formation of a covalent crosslinkage and non-covalent weak bindings between the inhibitor and proteases. Bioch. Biophys. Acta 482:412 (1977b).

    Article  CAS  Google Scholar 

  65. R.L. Nachman, E.A. Jaffe, Subcellular platelet factor VIII antigen and von Willebrand factor. J. Exp. Med. 141:1101 (1975).

    Article  PubMed  CAS  Google Scholar 

  66. P. Needleman, P.S. Kulkarni, A. Raz, Coronary tone modulation: formation and actions of prostaglandins endoperoxides and thromboxanes. Science 195:409 (1977).

    Article  PubMed  CAS  Google Scholar 

  67. G.G. Neri Serneri, G.F. Gensini, R. Abbate, D. Prisco, C. Mugnaini, Soluble fibrinogen complexes and platelet aggregates in patients with history of myocardial infarction and chronic cerebrovascular disorders. A rationale for prophylactic therapy. Europ. Symp. on Platelet Aggregation, Coagulation Fibrinolysis and Atherosclerosis. (A. Strano ed.) p. 277, CEPI, Roma, 1976.

    Google Scholar 

  68. G.G. Neri Serneri, R. Abbate, G.F. Gensini, G. Masotti, Aterosclerosi e stati trombofilici. In: Atti dell’Ottantesimo Congresso della Società Italiana di Medicina Interna, p. 427, Pozzi L., Roma, 1979.

    Google Scholar 

  69. G.G. Neri Serneri, Relationships between system and ischaemic heart disease. In: Neri Serneri G.G., Mason T.D. (eds.): Myocardial Infarction. Excerpta Medica, Amsterdam, 1979.

    Google Scholar 

  70. G.G. Neri Serneri, High molecular weight fibrinogen complexes in the assessment of hypercoagulability, In: Neri Serneri G.G., Prentice C.R.M. (eds.) Haemostasis and Thrombosis, p. 211. Academic Press, London 1979.

    Google Scholar 

  71. H.L. Nossel, I. Yudelman, R.E. Canfield, Measurement of fibrino-peptide A in human blood. J. Clin. Invest. 54:43 (1974).

    Article  PubMed  CAS  Google Scholar 

  72. J.R. O’Brien, M.D. Etherington, S. Jamieson, P. Lawford, S.V. Lincoln, N.J. Alkjaersig, Blood changes in atherosclerosis and long after myocardial infarction and venous thrombosis. Thromb. Diath. Haemorrh. 34:483 (1975).

    PubMed  Google Scholar 

  73. M. Pandolfi, L.O. Aimer, L. Holmberg, Increased von Willebrand antiemophylic factor in diabetic retinopathy. Acta Ophtalmol. 52:823 (1974).

    Article  CAS  Google Scholar 

  74. F. Panicucci, A. Sacripanti, E. Pinori, M. Vispi, B. Conte, L. Lecchini, Antithrombin III, heparin cofactor and anti-factor Xa in relation to age, sex and pathological conditions. Thromb. Haemost. 42:127 (1979).

    Google Scholar 

  75. S. Renaud, K. Kuba, C. Goulet, Y. Lemire, C. Allard, Relationship between fatty-acid composition of platelets and platelet aggregation in rat and man. Circ. Res. 26:343 (1970).

    Article  Google Scholar 

  76. R.D. Rosenberg, P.S. Damus, The purification and mechanism of action of human antithrombin-heparin cofactor. J. Biol. Chem. 248:6490 (1973).

    PubMed  CAS  Google Scholar 

  77. J.S. Rosenberg P. McKenna, R.D. Rosenberg, Inhibition of human factor IX by human antithrombin-hepatin cofactor. J. Biol. Chem. 250:8883 (1975).

    PubMed  CAS  Google Scholar 

  78. R.D. Rosenberg, G. Armand, L. Lam, Structure-function relationship of heparin species. Proc. Natl. Sci. USA 75:3065 (1978).

    Article  CAS  Google Scholar 

  79. R. Ross, J. Glomset, B. Kariya, R. Harker, A platelet dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc. Natl. Sci. USA 71:1207 (1974).

    Article  CAS  Google Scholar 

  80. R. Ross, J. Glomset, The pathogenesis of atherosclerosis. New Engl. J. Med. 295:369 (1976).

    Article  PubMed  CAS  Google Scholar 

  81. N. Salky, M. Dugdale, Platelet abnormalities in ischaemic heart disease. Am. J. Cardiol. 32:612 (1973).

    Article  PubMed  CAS  Google Scholar 

  82. S.C. Sharma, H.N. Seth, Platelet adhesiveness, plasma fibrinogen and fibrinolytic activity in acute myocardial infarction Br. Heart J. 40:526 (1978).

    Article  PubMed  CAS  Google Scholar 

  83. M.J. Silver, T.K. Bills, J.B. Smith, Platelets and prostaglandins: the key role of platelet phospholipase A2 activity. In: De Gaetano G., Garattini S. (eds.): Platelets: A multidisciplinary approach. Raven Press, New York, 1978.

    Google Scholar 

  84. J.B. Smith, C. Ingerirían, M.J. Silver, Persistence of thromboxane A-2 like material and platelet reíase inducing activity in plasma. J. Clin. Inv. 58:1119 (1976).

    Article  CAS  Google Scholar 

  85. J. Stibbe, Effect of exercise on F. VIII complex: proportional increase of Ristocetin cofactor (von Willebrand cofactor) and F. VIII AGN, but disproportional increase of F. VIII AHF. Thromb. Res., vol.10:163 (1977).

    Article  PubMed  CAS  Google Scholar 

  86. H. Stormorken, J. Herikssen, S. Nitter-Hange, A. Hellem, Antithrombin III and arterial thromboembolism. In: A. Strano (ed.) Proceedings of European Symposium on Advances in Coagulation, Fibrinolysis, Platelet Aggregation and Atherosclerosis. p. 19, CE.P.I., Roma, 1978.

    Google Scholar 

  87. A. Strano, S. Novo, G. Davi, G. Avellone, A. Pinto, La sindrome trombofilica delle arteriopatie obliteranti degli arti in-feriori. In: Atti dell’Ottantesimo Congresso della Società Italiana di Medicina Interna, p. 535, Pozzi L. Roma, 1979.

    Google Scholar 

  88. A. Strano, S. Novo, Prospettive sull’impiego degli antiaggreganti piastrinici nellTarteriosclerosi. Editoriale Giorn. Ital. Cardiol. 9:1 (1979).

    Google Scholar 

  89. A. Strano, S. Novo, G. Davi, G. Avellone, Fisiopatologia della coagulazione, dell’aggregazione piastrinica nella cardio-patia ischemica. In: Atti del XXXVIII Congresso Nazionale della Società Italiana di Cardiología, suppl. Boll. Soc. Ital. Cardiol., p. 499, Roma, 1980.

    Google Scholar 

  90. T. Strasser, Atherosclerosis and coronary heart disease: the contribution of epidemiology. WHO Chron. 26:7 (1972).

    PubMed  CAS  Google Scholar 

  91. J. Svensson, M. Hamberg, B. Samuelsson, Prostaglandin endo-peroxides IX. Characterization of rabbit aorta contracting substance (RCS) from guinea pig lung and human platelets. Acta Physiol. Scand. 94:222 (1975).

    Article  PubMed  CAS  Google Scholar 

  92. M.E. Switzer, P.A. McKee, Some effects of calcium on the activation of human factor VIII: von Willebrand factor protein by thrombin. J. Clin. Invest. 60:819 (1977).

    Article  PubMed  CAS  Google Scholar 

  93. A. Teien, V. Abildgaard, M. Höök, The anticoagulant effect of heparin sulphate and dermatan sulphate. Thromb. Res. 8: 859 (1976).

    Article  PubMed  CAS  Google Scholar 

  94. Z.I. Terashita, H. Fukui, K. Nishikawa, M. Hirata, S. Kikuchi, Coronary vasospastic action of thromboxane A2 in isolated working guinea pig hearts. Europ. J. Pharmacol. 53:94 (1978).

    Article  Google Scholar 

  95. C. Thomson, C.D. Forbes, C.R.M. Prentice, Relationship of factor VIII to Ristocetin induced platelet aggregation: effect of heterologous and acquired factor VIII antibodies. Thromb. Res. 3:363 (1973).

    Article  Google Scholar 

  96. J.F. Toole, R. Janeway, K. Choi, R. Cordell, F. Johnston, H.S. Muller, Transient ischemic attacks due to atherosclerosis: a prospective study of 160 patients. Arch. Neurol. 32:5 (1975).

    Article  PubMed  CAS  Google Scholar 

  97. V.T. Turitto, H.R. Baumgartner, Platelet interaction with sub-endothelium in a perfusion system: physical role of red blood cells. Microvasc. Res. 9:335 (1975).

    Article  PubMed  CAS  Google Scholar 

  98. E. von Kaulla, K.N. von Kauila, Antithrombin III and disease. Am. J. Clin. Pathol. 48:69 (1967).

    Google Scholar 

  99. P.N. Walsh, Albumin density gradient and washing of platelets and the study of platelet coagulant activities. Br. J. Haemat. 22:205 (1972).

    Article  CAS  Google Scholar 

  100. P.N. Walsh, Platelet coagulant activities and haemostasis: a hypothesis. Blood 43:597 (1974).

    PubMed  CAS  Google Scholar 

  101. H.J. Weiss, L.W. Hoyer, R.F. Rickles, A. Varma, J. Rogers, Quantitative assay of a plasma factor deficient in von Willebrand disease that is necessary for platelet aggregation: relationship to decrease F. VIII procoagulant activity and antigen content. J. Clin. Invest. 52:2708 (1973).

    Article  PubMed  CAS  Google Scholar 

  102. R.W. Wissler, Overview of problems of atherosclerosis. In: Scheinberg P. (ed.): Cerebrovascular disease, p. 56, Raven Press, New York, 1976.

    Google Scholar 

  103. S. Wessler, E.T. Yin, On the antithrombotic action of heparin. Thromb. Diath. Haemorrh. 32:71 (1974).

    PubMed  CAS  Google Scholar 

  104. J.C. White, Electron microscopic studies of platelet secretion. Prog. Haemostas. Thromb. 2:49 (1974).

    CAS  Google Scholar 

  105. L.D. Witte, K.L. Kaplan, H.L. Nossel, B.A. Lages, H.J. Weiss, S.G. De Witt, Studies of the release from human platelets of the growth factor for cultured human arterial smooth muscle cells. Circ. Res. 42:402 (1978).

    Article  PubMed  CAS  Google Scholar 

  106. N. Woolf, K.C. Carstairs, Infiltration and thrombosis in atherogenes is. A study using immunofluoréscent technique. Am. J. Pathol. 51:373 (1967).

    PubMed  CAS  Google Scholar 

  107. E.T. Yin, L.C. Guidice, S. Wessler, Inhibition of activated factor X-induced platelet aggregation: the role of heparin and the plasma inhibitor to activated factor X. J. Clin. Med. 81:298 (1973).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Clinical Medicine and Medical Therapy, University of Palermo, Piazza delle Cliniche, 2, 90127, Palermo, Italy

    G. Avellone, V. Mandalà, S. Novo, A. Pinto, F. P. Riolo, F. Cannioto & G. Raneli

Authors
  1. G. Avellone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Mandalà
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Novo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Pinto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. P. Riolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F. Cannioto
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. G. Raneli
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Clinical Medicine and Medical Therapy, University of Palermo, Palermo, Italy

    Antonio Strano

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Avellone, G. et al. (1984). Factor VIII and Antithrombin III in Atherosclerosis Obliterans of the Lower Limbs. In: Strano, A. (eds) Thrombosis and Cardiovascular Disease. Advances in Experimental Medicine and Biology, vol 164. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8616-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8616-2_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8618-6

  • Online ISBN: 978-1-4684-8616-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation