Skip to main content

Antithrombin III and Atherosclerosis

  • Chapter
Thrombosis and Cardiovascular Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 164))

  • 101 Accesses

Abstract

The mechanisms leading to the initiation of atherosclerosis are very complex. Since Duguid’s modification of Rokitansky’s theory, atherosclerosis has been related to thrombogenesis. Several investigators proposed the clumping of platelets to play a crucial role in the initiation of atheroma formation. When platelets are stimulated, they release polypeptide that is mitogenic to smooth muscle cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J.L. Kadish, Fibrin and atherosclerosis. A hypothesis. Atherosclerosis 33:409–413 (1979).

    Article  PubMed  CAS  Google Scholar 

  2. J. Conard, Congenital AT III deficiency. In: abstract book Vlème Congrès International sur la Thrombose, p.94 (1980).

    Google Scholar 

  3. O.R. Odegard, M.K. Fagerhol, M. Lie, Heparin cofactor activity and antithrombin III concentration in plasma related to age and sex. Scand. J. Haematol. 17:258–262 (1976).

    Article  PubMed  CAS  Google Scholar 

  4. T.W. Meade, W.R.S. North, Population-based distributions of haemostatic variables. Brit. Med. Bull. 33:283–288 (1977).

    PubMed  CAS  Google Scholar 

  5. A.C. Carvalho, R.S. Lees, R.A. Vaillancourt, R.B. Cabrai, R.M. Weinberg, R.W. Colman, Intravascular coagulation in hyper-lipidemia. Thrombos Res. 8:843–857 (1976).

    Article  CAS  Google Scholar 

  6. R.N. Banerjee, A.L. Sahni, V. Kumar, M. Arya, Antithrombin III deficiency in maturity onset diabetes mellitus and atherosclerosis. Thrombos. Diathes. Haemorrh. 31:339–344 (1974).

    CAS  Google Scholar 

  7. G. Follea, Antithrombine III et diabète sucré. Thèse Doct. Méd. Montpellier 1976.

    Google Scholar 

  8. E. Corbella, G. Miragliotta, R. Masperi, S. Villa, A. Bini, G. De Gaetano, G. Chiumello, Platelet aggregation and AT III levels in the diabetic children. Haemostasis 8:30–37 (1979).

    PubMed  CAS  Google Scholar 

  9. J. Conard, P. Barbier, M. Samama, Automated amidolytic method for AT III determination. Thrombos. Haemostas. 4:1350–1352 (1979).

    Google Scholar 

  10. J.H. Fuller, H. Keen, R.J. Jarret, T. Orner, T.W. Meade, R. Chakrabarti, W.R.S. North, Y. Stirling, Haemostatic variables associated with diabetes and its complications. Brit. Med. J. 2:964–966 (1979).

    Article  PubMed  CAS  Google Scholar 

  11. H.W. Pratt, Alterations in plasma antithrombin III activity in patients with myocardial infarction. In: abstract book Int. Soc. Thrombos. Haemostas. Washington D.C., p.404 (1980).

    Google Scholar 

  12. U. Hedner, I.M. Nilsson, Antithrombin III in clinical material. Thrombos. Res. 3:631–641 (1973).

    Article  CAS  Google Scholar 

  13. R.H. Yue, M.M. Gertler, T. Staar, R. Koutrouby, Alteration of plasma antithrombin III levels in ischemic heart disease. Thrombos Haemostas. 35:598–606 (1976).

    CAS  Google Scholar 

  14. J.R. O’Brien, Antithrombin III and heparin clotting times in thrombosis and atherosclerosis. Thromb. Piathes. Haemorrh. 32:116–123 (1974).

    Google Scholar 

  15. I. Innerfield, J.D. Goldfisher, H. Reicherreiss, J. Greenberg, Serum antithrombin in coronary artery disease. Am. J. Clin. Pathol. 65:64–68 (1976).

    PubMed  CAS  Google Scholar 

  16. H. Stormorken, J. Erikssen, Plasma antithrombin III and factor VIII antigen in relation to angiographic findings, angina and blood groups in middle-aged men. Thrombos. Haemostas. 38:874–880 (1977).

    CAS  Google Scholar 

  17. T.W. Meade, W.R.S. North, R. Chakrabarti, Y. Stirling, A.P. Haines, S.G. Thompson, M. Brozović, Haemostatic function and cardiovascular death: early results of a prospective study. Lancet 1:1050–1054 (1980).

    Article  PubMed  CAS  Google Scholar 

  18. T.B. Wahlberg, M. Blomback, J. Cash, Risk factors for ischemic heart disease reflected by six blood coagulation variables. Population comparisons between males, aged forty, from Edimburgh and Stockholm. In: abstract book Vlème Congrès International sur la Thrombose, Monte-Carlo, p. 229 (1980).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Conard, J., Castel, M., Samama, M. (1984). Antithrombin III and Atherosclerosis. In: Strano, A. (eds) Thrombosis and Cardiovascular Disease. Advances in Experimental Medicine and Biology, vol 164. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8616-2_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8616-2_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8618-6

  • Online ISBN: 978-1-4684-8616-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics