Abstract
Mechanisms underlying pulmonary hypertension are not completely clarified. However, it has been shown that pulmonary blood flow, alveolar pressure or left atrial pressure and blood viscosity do not change at all during hypoxia. Furthermore, it has been reported that alveolar hypoxia produces an increase in pulmonary pressure by a vasoconstrictive response although the mechanisms responsible for this phenomenon remain unclear (1–4).
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References
D.M. Aviado, The lung circulation, vol 1. Oxford Pergamon Press, 1965.
U.S. von Euler, G. Liljestrand, Observation on the pulmonary arterial blood pressure in the cat. Acta Physiol. Scand. 12:301 (1964).
G.G. Nahas, M.B. Visscher, G.W. Mather, F.J. Haddy, H.R. Warner, Influence of hypoxia on the pulmonary circulation in nonarcotized dogs. J. Appl. Physiol. 6:467 (1954).
D.M. Aviado, The pharmacology of the pulmonary circulation. Pharmacol. Rev. 12:159 (1960).
T.C. Lloyd Jr., The role of nerve pathways in the hypoxic vasoconstriction of lung. J. Appl. Physiol. 21:1351 (1961).
A.P. Fishman, H.W. Fritts, A. Cournand, Effects of acute hypoxia and exercise on the pulmonary circulation. Circulation 22: 220 (1960).
R.M. Goldring, G.M. Turino, G. Cohen, A.G. Jamieson, B.G. Bass, A.P. Fishman, the catecholamines in the pulmonary arterial pressor response to acute hypoxia. J. Clin. Invest. 41:1211 (1962).
E. Housley, S.W. Clarke, R.B. Hedworth-Whitty, J.M. Bishop, Effect of acute and chronic acidemia and associated hypoxia on the pulmonary circulation of patients with chronic bronchitis. Cardiovasc. Res. 4:482 (1970).
E.H. Bergofsky, Mechanisms underlying vasomotor regulation of regional pulmonary blood flow in normal and disease states. Am. J. Med. 57:378 (1974).
E.D. Silove, R.F. Grover, Effects of alpha adrenergic blockade and tissue catecholamine depletion on pulmonary vascular response to hypoxia. J. Clin. Invest. 47:274 (1968).
R.J. Porcelli, E.H. Bergofsky, Adrenergic receptors in pulmonary vasoconstrictor response to gaseous and humoral agents. J. Appl. Physiol. 34:483 (1973).
R.J. Porcelli, A. Viau, M. Demeny, E. Naftchin, E.H. Bergofsky, Relation between hypoxic pulmonary vasoconstriction, its humoral mediators and alpha-beta adrenergic receptors. The 19th Aspen lung conference. The pulmonary circulation. Chest 71 (Suppl.) 310 (1977).
A.P. Fishman, Hypoxia on the pulmonary circulation. How and where it acts. Circ. Res. 38:221 (1976).
H.N. Duke, E.M. Kollock, J.V. Marchant, Changes in pH of the perfusate during hypoxia in isolated perfused cat lungs. J. Physiol. (London) 157:90 (1960).
R. Detar, D.F. Bohr, Contractile responses of isolated vascular smooth muscle during prolonged exposure to anoxia. Am. J. Physiol. 2:1269 (1972).
G. Liljestrand, Chemical control of the pulmonary blood flow. Acta Physiol. Scand. 44:216 (1958).
J.L. Walker, The regulatory function of prostaglandins in the release of histamine and SRS A from passively sensitized human lung tissue. Advances in Biosciences 253:9 (1973).
A.A. Mathè, Studies on actions of prostaglandins in the lung. Acta Physiol. Scand. Suppl. 441 (1976).
A. Hague, K.L. Melmon, Role of histamine in hypoxic pulmonary hypertension in the rat. II depletion of histamine, serotonin and catecholamins. Circ. Res. 22:385 (1968).
A. Hague, N.C. Staub, Prevention of hypoxic vasoconstriction in cat lung by histamine-releasing agent 48/80. J. App1. Physiol. 26:693 (1969).
A. Susmano, R.A. Carleton, Prevention of hypoxic pulmonary hypertension by chlorpheniramine. J. Appl. Physiol. 31: 531 (1971).
F. Haas, E.H. Bergofsky, role of the mast-cell in the pulmonary pressor response to hypoxia. J. Clin. Invest. 51:3154 (1972).
C.A. Dowson, F.A. Delano, L.H. Hamilton and W.J. Stekiel, Histamine releasers and hypoxic vasoconstriction in isolated cat lungs. J. Appl. Physiol. 17:670 (1974).
F. Iodice, F. Piscione, G. Giuffrida, G. De Michele, Les effects des antihistaminiques sur 1’hypertension pulmonaire par hypoxie chronique chez 1’homme.
F. Rengo, B. Trimarco, M. Chiariello, B. Ricciardelli, M. Volpe, R. Violini, G. Rasetti, Histamine and hypoxic pulmonary hypertension. A quantitative study. Cardiovasc. Res. 12: 752 (1978).
F. Rengo, B. Trimarco, B. Ricciardelli, M. Volpe, R. Violini, L. Saccà, M. Chiariello, Effects of di sodium cromoglycate on hypoxic pulmonary hypertension in dog. J. Pharmacol. Exper. Ther. 211:686 (1979).
D. Bonaduce, P. Scarafile, L. De Caprio, M. Petretta, G. De Fabrizio, A. Carlomagno. Effetti della clorfeniramina sulle resistenze bronchiali in soggetti affetti da broncopneumopatia ostruttiva. In.: Atti Internacional Conference on Pneumology and of European Specialist Physicians. Eolian Islands, Messina 1977.
B.M. Altura, B.T. Altura, Effects of local anesthetics antihistamines and glucocorticoids on peripheral blood flow and vascular smooth muscle. Anesthesiology 41:197 (1974).
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© 1984 Plenum Press, New York
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Condorelli, M. et al. (1984). Mechanisms Underlying Pulmonary Hypertension by Hypoxemia. In: Strano, A. (eds) Thrombosis and Cardiovascular Disease. Advances in Experimental Medicine and Biology, vol 164. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8616-2_31
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DOI: https://doi.org/10.1007/978-1-4684-8616-2_31
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