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Thrombosis and Cardiovascular Disease pp 193–209Cite as

Prostacyclin and its Analogues for the Therapy of Thromboembolic Disorders

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 164))

Abstract

The discovery that blood vessels synthesize and release an unstable arachidonic acid metabolite, prostacyclin, which is a potent vasodilator and inhibitor of platelet aggregation (Moncada, Gryglewski, Bunting and Vane, 1976) has implicated this prostanoid as an important factor in the regulation of vascular tone and haemostasis (Moncada and Vane, 1979). This bicyclic enol-ether is derived from the fatty acid precursor arachidonic acid via the unstable endoper-oxide intermediates. These are transformed by the action of an enzyme system, prostacyclin synthetase, which is located predominantly in vascular endothelium. It has become apparent that prostacyclin has many potential clinical applications for the management of thromboembolic disorders (Table 1).

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Authors and Affiliations

  1. Department of Prostaglandin Research, Langley Court, Beckenham, Kent, BR3 3BS, UK

    B. J. R. Whittle & S. Moncada

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  1. B. J. R. Whittle
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  2. S. Moncada
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Editors and Affiliations

  1. Institute of Clinical Medicine and Medical Therapy, University of Palermo, Palermo, Italy

    Antonio Strano

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© 1984 Plenum Press, New York

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Whittle, B.J.R., Moncada, S. (1984). Prostacyclin and its Analogues for the Therapy of Thromboembolic Disorders. In: Strano, A. (eds) Thrombosis and Cardiovascular Disease. Advances in Experimental Medicine and Biology, vol 164. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8616-2_20

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  • DOI: https://doi.org/10.1007/978-1-4684-8616-2_20

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4684-8616-2

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