Abstract
The nuclear magnetic resonance positions of the C-18 and C-19 methyl group protons in a series of A- and D-ring substituted steroidal androstane derivatives were measured and found to be in excellent agreement with the values calculated using Zurcher’s tables. In the A -ring hydroxylated derivatives the magnitude of the coupling between the proton on the carbon bearing the hydroxyl group and the protons on the adjacent carbon atoms was also found to be consistent with the proposed structures.
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References
P. D. Klimstra, A. R. Zigman, R. E. Counsell, J. Med. Chem. 9, 924 (1966).
R. F. Zürcher, Helv. Chim. Acta 46, 2054 (1963).
R. F. Zürcher in NMR in Chemistry, B. Pesce (ed.), Academic Press, New York (1965) p. 45.
N. S. Bhacca and D. H. Williams, Applications of NMR Spectroscopy in Organic Chemistry, Holden-Day, San Francisco (1964), Chapter 2.
K. Tori and E. Kondo, Tetrahedron Letters, 1963 (10), 645.
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© 1970 Chicago Section of the Society for Applied Spectroscopy
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Klimstra, P.D., Bible, R.H. (1970). A Comparative NMR Study. In: Grove, E.L., Perkins, A.J. (eds) Developments in Applied Spectroscopy. Developments in Applied Spectroscopy, vol 7b. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8589-9_12
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DOI: https://doi.org/10.1007/978-1-4684-8589-9_12
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