Xanthine Oxidoreductase Inhibition by NADH as a Regulatory Factor of Purine Metabolism

Jeżewska, Maria M.; Kamiński, Z. W.

doi:10.1007/978-1-4684-8559-2_7

Xanthine Oxidoreductase Inhibition by NADH as a Regulatory Factor of Purine Metabolism

Maria M. Jeżewska⁴ &
Z. W. Kamiński⁴

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 122B))

Abstract

Xanthine oxidoreductase occurs in mammalian tissues mostly in a NAD⁺-dependent form¹. In rat liver this dehydrogenase form accounts for over 85 % of total enzyme, the rest being an intermediate dehydrogenase-oxidase form which preferably reacts with NAD% but can also use O₂as an electron acceptor². Both these forms are inhibited by NADH², in contrast to the O₂-dependent form³ arising from them^2.

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Authors and Affiliations

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-532, Warszawa, 36 Rakowiecka St., Poland
Maria M. Jeżewska & Z. W. Kamiński

Authors

Maria M. Jeżewska
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Z. W. Kamiński
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Fundación Jiménez Díaz, Madrid, Spain
Aurelio Rapado
M.R.C. Clinical Research Centre, Harrow, England
R. W. E. Watts
Department of Human Genetics, University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands
Chris H. M. M. De Bruyn

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Jeżewska, M.M., Kamiński, Z.W. (1980). Xanthine Oxidoreductase Inhibition by NADH as a Regulatory Factor of Purine Metabolism. In: Rapado, A., Watts, R.W.E., De Bruyn, C.H.M.M. (eds) Purine Metabolism in Man—III. Advances in Experimental Medicine and Biology, vol 122B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8559-2_7

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DOI: https://doi.org/10.1007/978-1-4684-8559-2_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8561-5
Online ISBN: 978-1-4684-8559-2
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