Abstract
Recent studies demonstrated that dATP concentration was markedly increased in erythrocytes from patient with adenosine deaminase deficiency1,2 . Deoxyadenosine is toxic to T lymphoblast in the presence of an inhibitor of adenosine deaminase. By the addition of deoxyadenosine, dATP accumulated in the cell and the level of dATP well corelated with the cytotoxicity4,5.
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References
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© 1980 Plenum Press, New York
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Ogasawara, N., Yamada, Y., Goto, H. (1980). Adenosine and Deoxyadenosine Kinase from Rat Liver. In: Rapado, A., Watts, R.W.E., De Bruyn, C.H.M.M. (eds) Purine Metabolism in Man—III. Advances in Experimental Medicine and Biology, vol 122B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8559-2_26
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DOI: https://doi.org/10.1007/978-1-4684-8559-2_26
Publisher Name: Springer, Boston, MA
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