Abstract
The importance of hypoxanthine-phosphoribosyltransferase (HPRT) to human biochemical genetics need not be stressed in this context. Although in some cases it has not been clear whether deficiencies of this enzyme are due to a structural mutation this seems to be well established in others. Hence a detailed knowledge of the structure and especially of essential amino acid residues seems desirable. Induced by a similar study on quinolinate-phosphoribosyltransferase1 and parallel to our experiments on specific irreversible inhibition chemical modification of HPRT was investigated.
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© 1980 Plenum Press, New York
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Gutensohn, W., Jahn, H. (1980). Chemical Modification of Hypoxanthine-Phosphoribosyltransferase and Its Protection by Substrates and Products. In: Rapado, A., Watts, R.W.E., De Bruyn, C.H.M.M. (eds) Purine Metabolism in Man—III. Advances in Experimental Medicine and Biology, vol 122B. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8559-2_21
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DOI: https://doi.org/10.1007/978-1-4684-8559-2_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8561-5
Online ISBN: 978-1-4684-8559-2
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