Abstract
The cellular events which are necessary for transducing signals from the binding of an agonist with its surface membrane receptor to the final cellular response are still much of a mystery. One particular class of receptors stimulates cells by inducing a rise in the cytosolic Ca + concentration and also by activating protein kinase C. To achieve this, the agonist-occupied receptor stimulates phospholipase C which hydrolyses inositol phospholipids, particularly phosphatidylinositol-4,5-bisphosphate. The result is the generation of the second messenger molecules inositol 1,4,5-trisphosphate and 1,2-diacylglycerol, which release intracellular Ca + stores and activate protein kinase C., respectively (Berridge, 1987).
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© 1989 Plenum Press, New York
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Lapetina, E.G., Crouch, M.F. (1989). Multiple Messenger Roles for the Inhibitory GTP-Binding Protein, G i , in Human Platelets. In: Catravas, J.D., Gillis, C.N., Ryan, U.S. (eds) Vascular Endothelium. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8532-5_17
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DOI: https://doi.org/10.1007/978-1-4684-8532-5_17
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