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Neurochemistry of Aging

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Aging and the Brain

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 3))

Abstract

Stimulated in part by rapid and parallel advances in biochemistry and neurobiology, the field of neurochemistry has been characterized by a remarkable expansion in the past decade. Despite this rapid advance, however, research on the neurochemistry of aging in man and other primates has been sparse and inconclusive. This paucity of research can be attributed in part to the long life span of man and the primates and in part to the broad, diversified, and exploratory focus on such biological mechanisms of aging as the extracellular components collagen and elastin, the search for age changes in particular cell types, tissue, or organs as a whole, and more recently the neuromolecular emphasis on age differences in a variety of intracellular organelles.

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References

  • Andrew, W. 1964. Changes in the nucleus with advancing age of the organism. In Advances in Gerontological Research. B.L. Strehler(ed.). New York: Academic Press, vol. 1, p. 87.

    Google Scholar 

  • Birren, J.E. 1959. Sensation, perception and modification of behavior in relation to the process of aging. In The Process of Aging in the Nervous System. J.E. Birren, H.A. Imus, and W.F. Windle (eds.). Springfield, Ill.: Charles C Thomas, p. 143.

    Google Scholar 

  • Birren, J.E. 1965. Age changes in speed of behavior: Its central nature and physiological correlates. In Behavior, Aging, and the Nervous System. A.T. Welford and J.E. Birren (eds.). Springfield, Ill.: Charles C Thomas, p. 191.

    Google Scholar 

  • Björkerud, S. 1964. Isolated lipofuscin granules: A survey of a new field. In Advances in Gerontological Research. B.L. Strehler(ed.). New York: Academic Press, vol. 1, p. 257.

    Google Scholar 

  • Bond, V.P.; Fliedner, T.M.; and Archambeau, J.O. 1965. Mammalian Radiation Lethality: A Disturbance in Cellular Kinetics. New York: Academic Press, p. 276.

    Google Scholar 

  • Bondareff, W. 1959. Morphology of the aging nervous system. In Handbook of Aging and the Individual. J.E. Birren (ed.). Chicago: The University of Chicago Press, p. 136.

    Google Scholar 

  • Brody, H. 1955. Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex. J. Comp. Neurol. 102:511.

    Article  PubMed  CAS  Google Scholar 

  • Bürger, M. 1957. Die chemische Biomorphose des menschlichen Gehirns. Abhandlungen der Sachsischen Akademie der Wissenschaften zu Leipzig, Mathematisch-naturwissenschaftliche Klasse 45:1.

    Google Scholar 

  • Curtis, H.J. 1963. Biological mechanisms underlying the aging process. Science 49:626.

    Google Scholar 

  • Dalton, A.J. 1961. Golgi apparatus and secretion granules. In The Cell: Biochemistry, Physiology, Morphology. J. Brachet and A.E. Mirsky (eds.). New York: Academic Press, p. 603.

    Google Scholar 

  • Dalton, M.M.; Hommes, O.R.; and Leblond, C.P. 1968. Correlation of glial proliferation with age in the mouse brain. J. Comp. Neurol. 134:397.

    Article  PubMed  CAS  Google Scholar 

  • Dixit, B.N., and Buckley, J.P. 1969. Brain 5-hydroxytryptamine and anterior pituitary activation by stress. Neuroendocrinology 4:32.

    Article  PubMed  CAS  Google Scholar 

  • Donahue, S.; Zeman, W.; and Watanabe, I. 1966. Electron microscopic observations in Batten’s disease. Proceedings Third International Symposium on The Cerebral Sphingolipidoses. Reprinted from Inborn Disorders of Sphingolipid Metabolism. New York: Pergamon Press, p. 3.

    Google Scholar 

  • Elens, A., and Wattiaux, R. 1969. Age-correlated changes in lysosomal enzyme activities: An index of ageing? Exp. Geront. 4:131.

    Article  CAS  Google Scholar 

  • Földi, M.; Zoltán, O. T.; and Gyori, I. 1970. Über die Wirkung von Kavain und Magnesium-Orotat auf die funktionellen Störungen bei der experimentellen lymphogenen Enzephalopathie. I. Mitteilung. Z. Geront. 3:97.

    Google Scholar 

  • Friede, R.L., and Samorajski, T. 1968. Myelin formation in the sciatic nerve of the rat. J. Neuropath. Exp. Neurol 27:546.

    Article  PubMed  CAS  Google Scholar 

  • Gatenby, J.B. 1953. The Golgi apparatus of the living sympathetic ganglion cells of the mouse, photographed by phase contrast microscopy. J. Roy. Micr. Soc. 73:61.

    Article  PubMed  CAS  Google Scholar 

  • Geller, E.; Yuwiler, A.; and Zolman, J.F. 1965. Effects of environmental complexity on constituents of brain and liver. J. Neurochem. 12:949.

    Article  PubMed  CAS  Google Scholar 

  • Gordon, P. 1971. Molecular approaches to the drug enhancement of deteriorated functioning in the aged. In Advances in Gerontological Research. B.L. Strehler (ed.). New York: Academic Press, vol. 3, p. 199.

    Google Scholar 

  • Harman, D. 1971. Free radical theory of aging: Effect of the amount and degree of unsaturation of dietary fat on mortality rate. J. Geront. 26:451.

    PubMed  CAS  Google Scholar 

  • Hendley, D.D.; Mildvan, A.S.; Reporter, M.C.; and Strehler, B.L. 1963. The properties of isolated human cardiac age pigment. II. Chemical and enzymatic properties. J. Geront. 18:250.

    PubMed  CAS  Google Scholar 

  • Hendley, D.D., and Strehler, B.L. 1965. Enzymic activities of lipofuscin age pigments: Comparative histochemical and biochemical studies. Biochim. Biophys. Acta 99:406.

    PubMed  CAS  Google Scholar 

  • Himwich, H.E. 1959. Biochemistry of the nervous system in relation to the process of aging. In The Process of Aging in the Nervous System. J.E. Birren, H.A. Imus, and W.F. Windle (eds.). Springfield: Charles C Thomas, p. 101.

    Google Scholar 

  • Himwich, W.A., and Himwich, H.E. 1959. Neurochemistry of Aging. In Handbook of Aging and the Individual. J.E. Birren (ed.). Chicago: The University of Chicago Press, p. 187.

    Google Scholar 

  • Horrocks, L.A. 1968. Composition of mouse brain during development. J. Neurochem. 15:483.

    Article  PubMed  CAS  Google Scholar 

  • Horrocks, L.A. 1969. Metabolism of ethanolamine phosphoglycerides of mouse brain myelin and microsomes. J. Neurochem. 16:13.

    Article  PubMed  CAS  Google Scholar 

  • Horrocks, L.A. Content, composition and metabolism of mammalian and avian lipids that contain ether groups. In The Ether Bond in Lipids. F. Snyder (ed.). New York: Academic Press (in press).

    Google Scholar 

  • Huemer, R.P.; Bickert, C; Lee, K.D.; and Reeves, A.E. 1971. Mitochondrial studies in senescent mice. I. Turnover of brain mitochondrial lipids. Exp. Geront. 6:259.

    Article  CAS  Google Scholar 

  • Krech, D.; Rosenzweig, M.R.; and Bennett, E.L. 1966. Environmental impoverishment, social isolation and changes in brain chemistry and anatomy. Physiol. Behav. 1:99.

    Article  CAS  Google Scholar 

  • Kristensson, K., and Sourander, P. 1966. Occurrence of lipofuscin in inherited metabolic disorders affecting the nervous system. J. Neurol. Neurosurg. Psychiat. 29:113.

    Article  Google Scholar 

  • MacKinnon, P.C.B.; Simpson, R.A.; and MacLennan, C. 1969. In vivo and in vitro techniques used in the study of RNA synthesis in the brains of rats and mice at various ages from birth to senility. J. Anat. 104:351.

    PubMed  CAS  Google Scholar 

  • McCay, C.M. 1952. Chemical aspects of ageing and the effect of diet upon ageing. In Cowdry’s Problems of Ageing. A.I. Lansing (ed.). Baltimore: Williams and Wilkins, p. 139.

    Google Scholar 

  • Miyagishi, T.; Takahata, N.; and Iizuka, R. 1967. Electron microscopic studies on the lipo-pigments in the cerebral cortex nerve cells of senile and vitamin E deficient rats. Acta Neuropath. 9:7.

    Article  PubMed  CAS  Google Scholar 

  • Nikaido, T.; Austin, J.; Rinehart, R.; Trueb, L.; Hutchison, J.; Stukenbrok, H.; and Miles, B. 1971. Studies in ageing of the brain. I. Isolation and preliminary characterization of Alzheimer plaques and cores. Arch. Neurol. 25:198.

    Article  PubMed  CAS  Google Scholar 

  • Norton, W.T.; Poduslo, S.E.; and Suzuki, K. 1967. Rat brain myelin: Compositional changes during development. Abstract, Int. Soc. Neurochem., Strasbourg, p. 161.

    Google Scholar 

  • Norton, W.T., and Poduslo, S.E. 1970. Neuronal soma and whole neuroglia of rat brain: A new isolation technique. Science 167:1144.

    Article  PubMed  CAS  Google Scholar 

  • Oeriu, S. 1964. Proteins in development and senescence. In Advances in Gerontological Research. B.L. Strehler (ed.). New York: Academic Press, vol. 1, p. 23.

    Google Scholar 

  • Ordy, J.M.; Samorajski, T.; Zeman, W.; and Curtis, H.J. 1967. Interaction effects of environmental stress and deuteron irradiation of the brain on mortality and longevity of C57BL/10 mice. Proc. Soc. Exp. Biol. Med. 126:184.

    Google Scholar 

  • Ordy, J.M.; Samorajski, T.; Hershberger, T.J.; and Curtis, H.J. 1971. Life-shortening by deuteron irradiation of the brain in C57BL/10 female mice. J. Geront. 26:194.

    PubMed  CAS  Google Scholar 

  • Palade, G.E. 1955. Studies on the endoplasmic reticulum. II. Dispositions in cells in situ. J. Biophys. Biochem. Cytol. 1:567.

    Article  PubMed  CAS  Google Scholar 

  • Palay, S.L., and Palade, G.E. 1955. The fine structure of neurons. J. Biophys. Biochem. Cytol. 1:69.

    Article  PubMed  CAS  Google Scholar 

  • Pallis, C.A.; Duckett, S.; and Pearse, A.G.E. 1967. Diffuse lipofuscinosis of the central nervous system. Neurology 17:381.

    PubMed  CAS  Google Scholar 

  • Price, G.B.; Modak, S.P.; and Makinodan, T. 1971. Age-associated changes in the DNA of mouse tissue. Science 171:917.

    Article  PubMed  CAS  Google Scholar 

  • Raine, CS.; Poduslo, S.E.; and Norton, W.T. 1971. The ultrastructure of purified preparations of neurons and glial cells. Brain Res. 27:11.

    Article  PubMed  CAS  Google Scholar 

  • Reichet, W., and Garcia-Bunuel, R. 1970. Pathologic findings in progeria: Myocardial fibrosis and lipofuscin pigment. Amer. J. Clin. Path. 53:243.

    Google Scholar 

  • Retzlaff, E., and Fontaine, J. 1965. Functional and structural changes in motor neurons with age. In Behavior, Aging, and the Nervous System. A.T. Welford and J.E. Birren (eds.). Springfield, Ill.: Charles C Thomas, p. 340.

    Google Scholar 

  • Ring, G.C.; Bosch, M.; and Lo, CS. 1970. Effects of exercise on growth, resting metabolism and body composition of Fischer rats. Proc. Soc. Exp. Biol. Med. 133:1162.

    PubMed  CAS  Google Scholar 

  • Rouser, G., and Yamamoto, A. 1969. Lipids. In Handbook of Neurochemistry. A. Lajtha (ed.). New York: Plenum Press, vol. 1, p. 121.

    Google Scholar 

  • Samorajski, T., and Friede, R.L. 1968. A quantitative electron microscopic study of myelination in the pyramidal tract of rat. J. Comp. Neurol. 134:323.

    Article  PubMed  CAS  Google Scholar 

  • Samorajski, T.; Ordy, J.M.; and Rady Reimer, P. 1968. Lipofuscin pigment accumulation in the nervous system of aging mice. Anat. Rec. 160:555.

    Article  PubMed  CAS  Google Scholar 

  • Samorajski, T.; Ordy, J.M.; Zeman, W.; and Curtis, H.J. 1970. Brain irradiation and aging. Interdiscipl. Topics Gerontol. 7:72.

    CAS  Google Scholar 

  • Samorajski, T.; Friede, R.L.; and Ordy, J.M. 1971. Age differences in the ultrastructure of axons in the pyramidal tract of the mouse. J. Geront. 26:542.

    PubMed  CAS  Google Scholar 

  • Samorajski, T.; Rolsten, C.; and Ordy, J.M. 1971. Changes in behavior, brain, and neuroendocrine chemistry with age and stress in C57BL/10 male mice. J. Geront. 26:168.

    PubMed  CAS  Google Scholar 

  • Silberberg, M., and Silberberg, R. 1955. Diet and life span. Physiol. Rev. 35:347.

    PubMed  CAS  Google Scholar 

  • Smookler, H.H., and Buckley, J.P. 1969. Relationship between brain catecholamine synthesis, pituitary adrenal function and the production of hypertension during prolonged exposure to environmental stress. Int. J. Neuropharmacol. 8:33.

    Article  PubMed  CAS  Google Scholar 

  • Strehler, B.L. 1960. Dynamic theories of aging. In Aging... Some Social and Biological Aspects. N.W. Shock (ed.). Washington, D.C.: American Association for Advancement of Science, p. 273.

    Google Scholar 

  • Strehler, B.L. 1962. Aging of subcellular components. In Time, Cells, and Aging. B.L. Strehler (ed.) New York: Academic Press, p. 158.

    Google Scholar 

  • Strehler, B.L., and Mildvan, A.S. 1962. Studies on the chemical properties of lipofuscin age pigment. In Biological Aspects of Ageing. N.W. Shock (ed.). New York: Columbia University Press, p. 174.

    Google Scholar 

  • Strehler, B.L. 1966. Code degeneracy and the aging process: A molecular genetic theory of aging. In Proceeding 7th International Congress of Gerontology. Vienna: Viennese Medical Academy.

    Google Scholar 

  • Sulkin, N.M., and Srivanij, P. 1960. The experimental production of senile pigments in the nerve cells of young rats. J. Geront. 15:2.

    PubMed  CAS  Google Scholar 

  • Sun, A., and Samorajski, T. 1970. Effects of ethanol on the activity of adenosine triphosphatase and acetylcholinesterase in synaptosomes isolated from guinea-pig brain. J. Neurochem. 17:1365.

    Article  PubMed  CAS  Google Scholar 

  • Tauchi, H., and Sato, T. 1968. Age changes in size and number of mitochondria of human hepatic cells. J. Geront. 23:454.

    PubMed  CAS  Google Scholar 

  • Terry, R. 1963. The fine structure of neurofibrillary tangles in Alzheimer’s disease. J. Neurol. Exp. Neuropath. 32:629.

    Article  Google Scholar 

  • Terry, R.; Gonatas, N.; and Weiss, M. 1964. Ultrastructural studies in Alzheimer’s presenile dementia. Amer. J. Path. 44:269.

    PubMed  CAS  Google Scholar 

  • Tilney, R., and Rosett, J. 1931. The value of brain lipoids as an index of brain development. Bull. Neurol Inst. (New York) 1:28.

    Google Scholar 

  • Umana, R., and Brekke, J.H. 1969. Changes in protease and ribonuclease activities in brain and liver during the life-span of the rat. Growth 33:157.

    PubMed  CAS  Google Scholar 

  • Varkonyi, T.; Domokos, H.; Maurer, M.; Zoltan, Ö.T.; Csillik, B.; and Földi, M. 1970. Die Wirkung von D,L-Kavain und Magnesium-Orotat auf die feinstrukturellen neuropathologischen Veränderungen der experimentellen lymphogenen Enzephalopathie. Z. Geront. 3:254.

    Google Scholar 

  • Wisniewski, T.; Terry, R.; and Hirano, A. 1970. Neurofibrillary pathology. J. Neuropath. Exp. Neurol. 29:163.

    Article  PubMed  CAS  Google Scholar 

  • Wulff, V.J.; Samis, H.V. Jr.; and Falzone, J.A. Jr. 1967. The metabolism of ribonucleic acid in young and old rodents. In Advances in Gerontological Research. B.L. Strehler (ed.). New York: Academic Press, vol. 2, p. 37.

    Google Scholar 

  • Zeman, W., and Alpert, M. 1963. On the nature of the “stored” lipid substances in juvenile amaurotic idiocy. Ann. Histochim. 8:255.

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory of Neurochemistry, Cleveland Psychiatric Institute, Cleveland, Ohio, USA

    Thaddeus Samorajski Ph.D.

  2. Department of Psychology, Northern Illinois University, DeKalb, Illinois, USA

    J. Mark Ordy Ph.D.

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  1. Thaddeus Samorajski Ph.D.
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  2. J. Mark Ordy Ph.D.
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Editors and Affiliations

  1. Gerontology Research Section, Texas Research Institute of Mental Sciences, Houston, Texas, USA

    Charles M. Gaitz (Chief) (Chief)

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© 1972 Plenum Press, New York

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Samorajski, T., Ordy, J.M. (1972). Neurochemistry of Aging. In: Gaitz, C.M. (eds) Aging and the Brain. Advances in Behavioral Biology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8503-5_5

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  • DOI: https://doi.org/10.1007/978-1-4684-8503-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8505-9

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