Abstract
It is well recognized since early studies on oxidative phosphorylation1,2 that ADP greatly stimulates mitochondrial respiration. This reflects a tight coupling between electron transport and ATP synthesis. Nevertheless, in the absence of added ADP or after its complete phosphorylation to ATP, mitochondrial respiration does not come to a stop but continues at a low, though measurable, level designated as state 4 2 or the resting state. This respiration may be partly attributed to external ATPase and/or recycling of Ca2+. However, even if production of ATP or its exit from mitochondria is blocked and the uptake of Ca2+ is prevented, there still remains a significant oxygen uptake. In terms of the chemiosmotic theory of energy coupling,3 this resting state respiration can be interpreted as compensating the proton leak through the inner mitochondrial membrane.
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© 1986 Plenum Press, New York
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Wojtczak, L., Duszyński, J., Puka, M., Żółkiewska, A. (1986). Nonlinearity of the Flux/Force Relationship in Respiring Mitochondria as a Possible Consequence of Heterogeneity of Mitochondrial Preparations. In: Papageorgiou, G.C., Barber, J., Papa, S. (eds) Ion Interactions in Energy Transfer Biomembranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8410-6_12
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DOI: https://doi.org/10.1007/978-1-4684-8410-6_12
Publisher Name: Springer, Boston, MA
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