Abstract
During the last decades, biological interest in depression has focused on neuroendocrinological disturbances. Accordingly the involvement of minor peptide hormones present in the brain have been hypothesized and studied. Thus an impaired thyrotropin (TSH) response to thyrotropin releasing hormone (TRH) has been described (Prange et al., 1972; Kastin et al., 1972), and furthermore Kirkegaard et al. (1975) and Kirkegaard and Smith (1978) showed that changes in TSH response to TRH during electroconvulsive therapy (ECT) seem to be of predictive value for the post-treatment course of the disease. Moreover, Kirkegaard et al. (1979), reported high levels of TRH in cerebrospinal fluid (CSF) in endogenous depression.
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References
Checkley, S.A., and Crammer, J.L., 1977, Hormone responses to methylamphetamine in depression: A new approach to the noradrenaline depletion hypothesis, Br J Psychiatry, 131:582.
Checkley, S.A., Slade, A.P., and Shur, E., 1981, Growth hormone and other responses to clonidine in patients with endogenous depression, Br J Psychiatry, 138:51.
De Wied, D., 1977, Peptides and behavior, Life Sci, 20:195.
Fahrenkrug, J., 1979, Vasoactive intestinal polypeptide: measurement, distribution and putative neurotransmitter function, Digestion, 19:149.
Gerner, R.H., and Yamada, T., 1982, Altered neuropeptide concentrations in cerebrospinal fluid of psychiatric patients, Brain Res, 238:298.
Gjerris, A., Fahrenkrug, J., Bojholm, S., and Rafaelsen, O. J., 1981, Vasoactive Intestinal Polypeptide (VIP) in cerebrospinal fluid in psychiatric disorders, in: “Biological Psychiatry”, C. Perris, G. Struwe, and B. Jansson, eds., Elsevier/Borth-Holland Biomedical Press, Amsterdam, 565.
Gjerris, A., Rafaelsen, O.J., Vendsborg, P., and Rehfeld, J.,1983,Gastrointestinal peptides in cerebrospinal fluid in psychiatric disorders, J Affective Pis, to be published.
Gold, P.W. and Goodwin, F.K., 1978, Vasopressin in affective illness, Lancet, i:1233.
Hokfelt, T., Johansson, O., Ljungdahl, A., Lundberg, J.M., and Schultzberg, M., 1980a, Peptidergic neurones, Nature, 284:515.
Hokfelt, T., Rehfeld, J.F., Skirboll, L., Ivemark, B., Goldstein, M., and Markey, K., 1980b, Evidence for coexistence of dopamine and CCK in meso-limbic neurones, Nature, 285:476.
Itoh, H., Tanoue, S., Yagi, G., Tateyama, M., Kamisada, M., Fujii, Y., Takamiya, M., and Nakajima, S., 1982, Clinical study on the psychotropic effects of caerulein — an open clinical trial in. chronic schizophrenic patients, Keio J Med, 31:71.
Johansson, B.B., Fahrenkrug, J., Wikkelso, C., Andersen, O., and Blomstrand, C., 1982, Vasoactive intestinal polypeptide in human cerebrospinal fluid, Front Horm Res, 9:189.
Kastin, A.J., Ehrensing, R.H., Schalch, D.S., and Anderson, M.S., 1972, Improvement in mental depression with decreased thyrotropin response after administration of thyrotropinreleasing hormone, Lancet, ii:740.
Kirkegaard, C., Norlem, N., Lauridsen, U.B., and Bjorum, N., 1975, Prognostic value of thyrotropinreleasing hormone stimulation test in endogenous depression, Acta Psychiatr Scand, 52:170.
Kirkegaard, C. and Smith, E., 1978, Continuation therapy in endogenous depression controlled by changes in the TRH stimulation test, Psychol Med, 8:501.
Kirkegaard, C., Faber, J., Hummer, L., and Rogowski, P., 1979, Increased levels of TRH in cerebrospinal fluid from patients with endogenous depression, Psychoneuroendocrinology, 4:227.
Koob, G.E. and Bloom, F.E., 1982, Behavioral effects of neuropeptides: Endorphins and vasopressin, Annu Rev Physiol, 44:571.
Laakmann, G., 1980, Effect of antidepressants on the secretion of pituitary hormones in healthy subjects, neurotic depressive patients and endogenous depressive patients, Nervenarzt, 51:725.
Maroji, T., Watanabee, N., Aoki, N., and Itoh, S., 1982, Antipsychotic effects of ceruletide (caerulein) on chronic schizophrenia, Arch Gen Psychiatry, 39:485.
Matussek, N., Ackenheil, M., Hippius, H., Müller, F., Schroder, H.-Th., Schultes, H., and Wasilewski, B., 1980, Effect of Clonidine on growth hormone release in psychiatric patients and controls. Psychiatry Res, 2:25.
Prange, Jr., A.J., Lara, P.P., Wilson, I.C., Alltop, L.B., and Breese, G.R., 1972, Effects of thyrotropinreleasing hormone in depression, Lancet, ii:999.
Rafaelsen, O.J., 1980, Biology of manic-melancholic disorders, Med J Aust, 1:637.
Rehfeld, J.F., 1978, Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine, J Biol Chem, 253:4022.
Sachar EJ, Altman, N. Gruen, P.H., Glassman, A., Halpern, F.S., and Sassin, J., 1975, Human growth hormone response to levodopa, Arch Gen Psychiatry, 32:502.
Sachar, E.J., Finkelstein, J., and Hellmann, L., 1971, Growth hormone responses in depressive illness. I. Response to insulin tolerance test, Arch Gen Psychiatry, 25:263.
Weingartner, H., Gold, P., Ballenger, J.C., Smallberg, S.A., Summers, R., Rubinow, D.R., Post, R.M., and Goodwin, F.K., 1981, Effects of vasopressin on human memory functions, Science 211:601.
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Rafaelsen, O.J. (1985). Peptides in Major Psychoses. In: Pichot, P., Berner, P., Wolf, R., Thau, K. (eds) Biological Psychiatry, Higher Nervous Activity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8329-1_8
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DOI: https://doi.org/10.1007/978-1-4684-8329-1_8
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