Abstract
It has been shown that the mechanism by which cytolytic T lymphocytes (CTL)2 lyse target cells can be divided into three successive steps (reviewed in 1): (i) binding of CTL to target cells (adhesion formation), (ii) the action of CTL upon target cells to cause the targets to become irreversibly committed to lyse (programming for lysis, also called the lethal hit), and (iii) actual target cell lysis which occurs independent of continued contact between target cells and CTL. However, the molecular mechanisms by which these processes occur are poorly understood. Studies with monoclonal antibodies which can inhibit lysis in the absence of complement have permitted identification of several molecules which appear to play a role in the cytolytic mechanism (reviewed in 2–6). These include Lyt 2 and its human homologues (2–5), LFA-1 (2–5), T3 (7, 8), and clonotypic molecules which likely represent the T cell receptor (9, 10). Lyt 2 and LFA-1 appear to play a role in the binding of CTL to target cells (3, 5) whereas T3 may serve as a triggering link between the antigen-specific receptor and the lethal hit (6). No molecules have yet been identified which have been shown unambiguously to be involved in the actual delivery of the lethal hit.
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© 1985 Plenum Press, New York
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Gately, M.K., Dick, M.D., Masuno, T., McCarron, R.M., Macchi, B. (1985). p215 and p24: Two Membrane-Associated Proteins Expressed on Cloned Cytolytic T-Cells but not on Cloned Helper T-Cells. In: Henkart, P., Martz, E. (eds) Mechanisms of Cell-Mediated Cytotoxicity II. Advances in Experimental Medicine and Biology, vol 184. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-8326-0_27
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DOI: https://doi.org/10.1007/978-1-4684-8326-0_27
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