Skip to main content
SpringerLink
Log in

Dye—Light Phototherapy of Viral Bacterial, and Fungal Infections

  • Chapter
The Science of Photomedicine

Part of the book series: Photobiology ((PB))

Abstract

In 1899 Oscar Raab (1), a student in Dr. H. von Tappeiner’s Munich laboratory, observed that paramecia were killed in the presence of acridine dye and light but were unharmed in the presence of acridine dye in the dark. During the next few years of the early 20th century, von Tappeiner and Jodlbauer (2–4) conducted a long series of experiments with the dye-light reaction and coined the term “photodynamische erscheinung” (photodynamic action). They demonstrated that many dyes photosensitize a wide variety of microorganisms in vitro (Fig. 20–1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Raab, O. (1900): Ueber die Wirkung Huoreseierender Stoffe und Infusorien. Z. Biol. 39:524–526.

    CAS  Google Scholar 

  2. von Tappeiner, H., and Jodlbauer, A. (1904): Ueber die Wirkung der photodynamishen Stoffe auf Protozoen und Enzyme. Dtsch. Arch. Klin. Med. 80:427.

    Google Scholar 

  3. von Tappeiner, H., and Jodlbauer, A. (1907): Die sensibilisierende Wirkung Fluorescier-ender Substanzen. Vogel, Leipzig.

    Google Scholar 

  4. von Tappeiner, H. (1909): Die photodynamische Erscheinung (Sensibilisierung durch fluoressierende Stoffe). Ergeb. Physiol. 8:698–741.

    Article  Google Scholar 

  5. Chavarria, A. P., and Clark, J. H. (1924): The reaction of pathogenic fungi to ultraviolet light. Am. J. Hygiene 4:639–649.

    Google Scholar 

  6. Clifton, C. E. (1931): Photodynamic action of certain dyes on the inactivation of Staphylococcus bacteriophage. Proc. Soc. Exp. Biol. Med. 28:745–746.

    CAS  Google Scholar 

  7. Perdrau, J. R., and Todd, C. (1933): The photodynamic action of methylene blue on certain viruses. Proc. R. Soc. Lond. 112:288–298.

    Article  CAS  Google Scholar 

  8. Orlob, G. B. (1967): Inactivation of purified plant viruses and their nucleic acids by photosensitizing dyes. Virology 31:402–413.

    Article  PubMed  CAS  Google Scholar 

  9. Hessler, A. Y. (1965): Acridine resistance in bacteriophage T2H as a function of dye penetration measured by mutagenesis and photoinactivation. Genetics 52:711–722.

    PubMed  CAS  Google Scholar 

  10. Wallis, C., and Melnick, J. L. (1965): Photodynamic inactivation of animal viruses. Photochem. Photobiol. 41:159–170.

    Article  Google Scholar 

  11. Wallis, C., and Melnick, J. L. (1965): Photodynamic inactivation of enteroviruses. J. Bacteriol. 89:41–46.

    PubMed  CAS  Google Scholar 

  12. Felber, T. D., Smith, E. B., Knox, J. M., et al. (1973): Photodynamicinactivationofherpes simplex. J. AMA 223:289–292.

    Google Scholar 

  13. Kaufman, R. H., Gardner, H. L., Brown, D., et al. (1973): Herpes genitalis treated by photodynamic inactivation of virus. Obstet. Gynecol. 117:1144–1146.

    CAS  Google Scholar 

  14. Lefebvre, E. B., and McNellis, E. E. (1973): Photoinactivation of herpes simplex. J. AMA 224:1039.

    CAS  Google Scholar 

  15. Hinthorne, D. R., Baker, L. H., Romig, D. A., et al. (1976): Recurrent conjugal neuralgia caused byHerpesvirus hominis type 2. J. AMA 236:587–588.

    Google Scholar 

  16. Rubin, M. B., and Heaton, C. L. (1972): Phototherapy of recurrent cutaneous Herpesvirus hominis infection with acridine orange and ultraviolet light. In: Proceedings of the 14th International Congress of Dermatology, Padua-Venice, May 22–27, pp. 162–166.

    Google Scholar 

  17. Chang, T., Weinstein, L. (1975): Eczema herpeticum: treatment with methylene blue and light. Arch. Dermatol. 111:1174–1175.

    Article  PubMed  CAS  Google Scholar 

  18. Moore, C., Wallis, C., Melnick, J. L., et al. (1972): Photodynamic treatment of herpes keratitis. Infect. Immun. 5:169–171.

    PubMed  CAS  Google Scholar 

  19. Lanjer, J. D., Witcher, J. P., and Dawson, C. R. (1973): Proflavineand light in the treatment of experimental herpetic keratitis (abstract). Symp. Assoc. Res. Vis. Ophthalmol., p. 51.

    Google Scholar 

  20. Tara, C. S., Stanley, J. A., Kucera, L. J., et al. (1974): Photodynamic inactivation of herpes simplex keratitis. Arch. Ophthalmol. 92:51–53.

    Article  PubMed  CAS  Google Scholar 

  21. Lahav, M., Dueker, D., Bhatt, P. N., et al. (1975): Photodynamic inactivation in experimental herpetic keratitis. Arch. Ophthalmol. 93:207–214.

    Article  PubMed  CAS  Google Scholar 

  22. O’Day, D. M., Jones, B. R., Poirier, R., et al. (1975): Proflavine photodynamic viral inactivation in herpes simplex keratitis. Am. J. Ophthalmol. 79:941–948.

    PubMed  Google Scholar 

  23. Myers, M. G., Oxman, M. N., Clark, J. E., et al. (1975): Failure of neutral red photodynamic inactivation in recurrent herpes simplex infections. N. Engl. J. Med. 293:945–949.

    Article  PubMed  CAS  Google Scholar 

  24. Taylor, P. K., and Doherty, N. R. (1975): Comparison of the treatment of herpes genitalis in men with proflavine photoinactivation, idoxuridine ointment and normal saline. Br. J. Vener. Dis. 51:125–129.

    PubMed  CAS  Google Scholar 

  25. Roome, A. P., Tinkler, A. E., Hilton, A. L., et al. (1975): Neutralred with photoinactivation in the treatment of herpes genitalis. Br. J. Vener. Dis. 51:130–133.

    PubMed  CAS  Google Scholar 

  26. Kaufman, R. H., Adam, E., Mirkovic, R. R., et al. (1978): Treatment of genital herpes simplex virus infection with photodynamic inactivation. Am. J. Obstet. Gynecol. 132: 861–869.

    PubMed  CAS  Google Scholar 

  27. Rapp, F. (1973): Medical News: Photoinactivation of herpesvirus may be clinically hazardous. J. AMA 255:459–460.

    Google Scholar 

  28. Duff, R., and Rapp, F. (1971): Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2. Nature [New Biol] 233:48.

    Article  CAS  Google Scholar 

  29. Rapp, F., Li, J. H., and Jerkofsky, M. (1973): Transformation of mammalian cells by DNA-containing viruses following photodynamic inactivation. Virology 55:339–346.

    Article  PubMed  CAS  Google Scholar 

  30. Li, J. L., Jerkofsky, M. A., and Rapp, F. (1975): Demonstration of oncogenic potential of mammalian cells transformed by DNA-containing viruses following photodynamic inactivation. Int. J. Cancer 15:190–202.

    Article  PubMed  CAS  Google Scholar 

  31. Verwoerd, D. W., and Rapp, F. (1978): Biochemical transformation of mouse cells by herpes simplex virus type 2: enhancement by means of low-level photodynamic treatment. J. Virol. 26:200–202.

    PubMed  CAS  Google Scholar 

  32. Berger, R. S., and Papa, C. M. (1977): Photodye herpes therapy—Cassandra confirmed? J. AMA 238:133–134.

    CAS  Google Scholar 

  33. Berger, B. W., and Hori, Y. (1978): Multicentric Bowen’s disease of the genitalia. Arch. Dermatol. 114:1698–1699.

    Article  PubMed  CAS  Google Scholar 

  34. Wade, T. R., Kopf, A. W., and Ackerman, A. B. (1979): Bowenoid papulosis of the genitalia. Arch. Dermatol. 115:306–308.

    Article  PubMed  CAS  Google Scholar 

  35. Wade, T. R., and Ackerman, A. B. (1977): Squamous cell carcinoma in-situ: multiple lesions on the penis in young men. Arch. Dermatol. 113 1714.

    Google Scholar 

  36. Lupulescu, A., Mehregan, A. H., Rahbari, H., et al. (1977): Venereal warts vs Bowen disease. J. AMA 237:2520–2522.

    CAS  Google Scholar 

  37. Friedrich, E. G. (1972): Reversible vulvar atypia. Obstet. Gynecol. 39:173–181.

    PubMed  Google Scholar 

  38. Kopf, A. W., Ackerman, A. B., Wade, T., et al. (1978): Photodye herpes therapy. J. AMA 239:615.

    CAS  Google Scholar 

  39. Browning, C. H., and Gilmore, W. (1913): Bacteriocidal action and chemical constitution with special reference to basic benzol derivatives. J. Pathol. BacterioI. 18 144–146.

    Google Scholar 

  40. Albert, A. (1966): The Acridines, 2nd ed. Edward Arnold, London.

    Google Scholar 

  41. Mitchell, G. A. G., and Buttler, G. A. H. (1943): Proflavine in closed wounds. Lancet 2:749.

    Article  Google Scholar 

  42. Rank, B. K. (1944): Use and abuse of local antiseptics on wounds. Med. J. Aust. 2:629–636.

    Google Scholar 

  43. Albert, A., Rubbo, S. D., and Maxwell, M. (1942): The influence of chemical constitution on antiseptic activity. I. Study of the mono-amino acridines. Br. J. Exp. Pathol. 23:69–83.

    Google Scholar 

  44. Rubbo, S. D., Albert, R. J., Goldacre, M. E., et al. (1945): The influence of chemical constitution on antibacterial activity II: A general survey of the acridine series. Br. J. Exp. Pathol. 26:160–192.

    Google Scholar 

  45. Gordon, J., McLeod, J. W., and Mayr-Harting, A. (1947): The value of antiseptics as prophylactic applications to recent wounds. J. Hyg. (Camb.) 45:297–306.

    Article  CAS  Google Scholar 

  46. Heinmets, F., Vinegar, R., and Taylor, W. W. (1953): Studies on the mechanisms of the photosensitized inactivation of E. coli and reactivation phenomenon. J. Gen. Physiol. 36:207–226.

    Article  Google Scholar 

  47. Wallis, C., Melnick, J. L., and Phillips, C. A. (1965): Bacterial and fungal decontamination of virus specimens by differential photosensitization. Am. J. Epidemiol. 81:222–229.

    PubMed  CAS  Google Scholar 

  48. Cooney, J. J., and Krinsky, N. I. (1972): Photodynamic killing of Acholeplasma laidlawii. Photochem. Photobiol. 16:523–526.

    Article  CAS  Google Scholar 

  49. Dickey, R. F. (1962): Investigative studies in fungicidal powers of photodynamic action. J. Invest. Dermatol. 39:7–19.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Baylor College of Medicine, 77030, Houston, Texas, USA

    M. Jarratt, W. Hubler Jr. & W. Panek

Authors
  1. M. Jarratt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Hubler Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Panek
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    James D. Regan

  2. Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    John A. Parrish

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Jarratt, M., Hubler, W., Panek, W. (1982). Dye—Light Phototherapy of Viral Bacterial, and Fungal Infections. In: Regan, J.D., Parrish, J.A. (eds) The Science of Photomedicine. Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8312-3_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8312-3_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8314-7

  • Online ISBN: 978-1-4684-8312-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation