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Phototherapy of Hyperbilirubinemia

  • Chapter
The Science of Photomedicine

Part of the book series: Photobiology ((PB))

Abstract

Jaundice occurs in about half of all newly born infants, and is the visible expression of high concentrations of bilirubin in the circulating plasma. Bilirubin, a tetrapyrrole pigment derived from the heme moiety of hemoglobin, is carried in plasma bound primarily to albumin; small amounts may also be bound to red cell membranes. If the production of bilirubin exceeds the infant’s ability to conjugate and excrete it, this pigment accumulates in the circulation, a condition called “hyperbilirubinemia,” and thence is deposited in the skin and other tissues. If the amount of bilirubin in the plasma exceeds the available binding sites, it is believed to circulate in a free (unbound or loosely bound) form that can enter and damage the neural tissue of the brain, especially the basal ganglia.

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Author notes

  1. T. P. Vogl

    Present address: Nutrition Coordinating Committee, Office of the Director, National Institute of Health, 20205, Bethesda, Maryland, USA

Authors and Affiliations

  1. Department of Pediatrics, Rutgers University School of Medicine, 08861, Perth Amboy, New Jersey, USA

    T. R. C. Sisson

  2. Departments of Radiology and Pediatrics, Columbia University College of Physicians and Surgeons, 10027, New York, New York, USA

    T. P. Vogl

Authors
  1. T. R. C. Sisson
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  2. T. P. Vogl
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Editors and Affiliations

  1. Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    James D. Regan

  2. Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    John A. Parrish

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© 1982 Plenum Press, New York

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Sisson, T.R.C., Vogl, T.P. (1982). Phototherapy of Hyperbilirubinemia. In: Regan, J.D., Parrish, J.A. (eds) The Science of Photomedicine. Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8312-3_16

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  • DOI: https://doi.org/10.1007/978-1-4684-8312-3_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8314-7

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