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Topical and Systemic Approaches to Protection of Human Skin against Harmful Effects of Solar Radiation

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Part of the book series: Photobiology ((PB))

Abstract

Why is photoprotection of importance to humans? We must be in the light; we cannot be forced to work or live in the dark. The sun is necessary to sustain all life on earth. We are warmed by its rays, and we are able to see with eyes that respond to that portion of the solar spectrum known as visible light. Our skin and blood vessels respond to the electromagnetic spectrum of the sun in the form of sunburn and tanning reactions. Many of our daily rhythms are dependent upon the sunlight. Natural sunlight has always been recognized for, and endowed with, health-giving powers. Yet excessive amounts of this life-supporting radiation can be very damaging to our skin. There are two concerns about the deleterious effects of sun exposure: (1) the acute effects (e.g., sunburn, phototoxicity), and (2) the potential long-term risk of repeated sun exposure, namely, the development of actinic changes (wrinkling, premature aging, irregular thickening and thinning of epidermis, hyper- and hypopigmentation), keratosis, and both nonmelanoma and melanoma skin cancer (1–3).

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References

  1. Pathak, M. A., and Epstein, J. H. (1971): Normal and abnormal reactions to light. In: Dermatology in General Medicine, edited by T. B. Fitzpatrick, K. A. Arndt, W. H. Clark, Jr. et al., pp. 977–1036. McGraw-Hill, New York.

    Google Scholar 

  2. Parrish, J. A., White, H. A. D., and Pathak, M. A. (1979): Photomedicine. In: Dermatology in General Medicine, 2nd ed., edited by T. B. Fitzpatrick, A. Z. Eisen, K. Wolff, et al., pp. 942–994. McGraw-Hill, New York.

    Google Scholar 

  3. Pathak, M. A., Fitzpatrick, T. B., and Parrish, J. A. (1979): Photosensitivity and other reactions to light. In: Harrison’s Principles of Internal Medicine, 9th ed., edited by K. J. Isselbacher, et al., pp. 255–262. McGraw-Hill, New York.

    Google Scholar 

  4. Pathak, M. A. (1974): Physical units of radiation and some common terms used in photobiology. In: Sunlight and Man: Normal and Abnormal Photobiologic Responses, edited by M. A. Pathak, L. C. Harber, M. Seiji, et al. (T. B. Fitzpatrick, consulting editor), pp. 815–818. University of Tokyo Press, Tokyo.

    Google Scholar 

  5. Fitzpatrick, T. B. (1976): In: Halocarbons: Environmental Effects of Chlorofluoromethane Release, p. 123. Committee on Impacts of Stratospheric Change. Assembly of Mathematical and Physical Sciences, National Research Council, National Academy of Sciences, Washington, D. C.

    Google Scholar 

  6. Pathak, M. A., Jimbow, K., and Szabo, G., et al. (1976): Sunlight and melanin pigmentation. In: Photochemical and Photobiological Reviews, Vol. 1, edited by K. C. Smith, pp. 211–239. Plenum Press, New York.

    Chapter  Google Scholar 

  7. Parrish, J. A., Pathak, M. A., and Fitzpatrick, T. B. (1971): Prevention of unintentional overexposure in topical psoralen treatment of vitiligo. Arch. Dermatol. 104:281–283.

    Article  PubMed  CAS  Google Scholar 

  8. Federal Register (1978): Sunscreen Drug Products for Over-the-Counter Human Drugs: Proposed Safety, Effective and Labeling Conditions. Department of Health, Education and Welfare, U. S. Food and Drug Administration. Vol. 43, No. 166, 08/25/78.

    Google Scholar 

  9. Pathak, M. A., Fitzpatrick, T. B., and Frenk, E. (1969): Evaluation of topical agents that prevent sunburn: superiority of para-aminobenzoic acid and its ester in ethyl alcohol. N. Engl. J. Med. 280:1459–1463.

    Article  PubMed  CAS  Google Scholar 

  10. Willis, I., and Kligman, A. M. (1969): Evaluation of sunscreens by human assay. J. Soc. Cosmet. Chem. 20:639.

    Google Scholar 

  11. Willis, I., and Kligman, A. M. (1970): Aminobenzoic acid and its esters. Arch. Dermatol. 102:405–417.

    Article  PubMed  CAS  Google Scholar 

  12. Langer, A., and Kligman, A. M. (1972): Further sunscreen studies of aminobenzoic acid. Arch. Dermatol. 105:851–855.

    Article  Google Scholar 

  13. Cripps, D. J., and Hegedus, S. (1974): Protection factor of sunscreens to monochromatic radiation. Arch. Dermatol. 109:202–204.

    Article  PubMed  CAS  Google Scholar 

  14. Fitzpatrick, T. B., Pathak, M. A., and Parrish, J. A. (1974): Protection of the human skin against the effects of the sunburn ultraviolet (290–320 nm). In: Sunlight and Man: Normal and Abnormal Photobiologic Responses, edited by M. A. Pathak, L. C. Harber, M. Seiji, et al. (T. B. Fitzpatrick, consulting editor), pp. 751–765. University of Tokyo Press, Tokyo.

    Google Scholar 

  15. Macleod, T. M., and Frain-Bell, W. (1971): The study of the efficacy of some agents used for the protection of the skin from exposure to light. Br. J. Dermatol. 84:266–281.

    Article  PubMed  CAS  Google Scholar 

  16. Kaidbey, K. H., and Kligman, A. M. (1978): Laboratory methods for appraising the efficacy of sunscreens. J. Soc. Cosmet. Chem. 29:525–536.

    CAS  Google Scholar 

  17. Knox, J. M., Guin, J., and Cockerell, E. G. (1957): Benzophenones. Ultraviolet light absorbing agents. J. Invest. Dermatol. 29:435–444.

    PubMed  CAS  Google Scholar 

  18. Sayre, R. M., Desrochers, D. L., and Marlowe, E. (1978): The correlation of indoor solar simulator and natural sunlight testing of sunscreen products. Arch. Dermatol. 114:1649–1651.

    Article  PubMed  CAS  Google Scholar 

  19. Sayre, R. M., Marlowe, E., Poh Agin, P., et al. (1979): Performance of six sunscreen formulations of human skin. Arch. Dermatol. 115:46–49.

    Article  PubMed  CAS  Google Scholar 

  20. Fusaro, R. M., Runge, W. J., and Johnson, J. A. (1972): Protection against light sensitivity with dihydorxyacetone-naphthoquinone. Int. J. Dermatol. 11:67–70.

    Article  PubMed  CAS  Google Scholar 

  21. Fisher, A. A. (1977): The presence of benzocaine in sunscreens containing glyceryl PABA (Escalol 106). Arch. Dermatol. 113:1299–1300.

    Article  PubMed  CAS  Google Scholar 

  22. Toby-Mathias, C. G., Maibach, H. I., and Epstein, J. H. (1978): Allergic contact Photodermatitis to para-aminobenzoic acid. Arch. Dermatol. 114:1665–1666.

    Article  Google Scholar 

  23. Kaidbey, K. H., and Kligman, A. M. (1978): Contact photoallergy to 6-methylcoumarin in proprietary sunscreens. Arch. Dermatol. 114:1709–1710.

    Article  PubMed  CAS  Google Scholar 

  24. Fitzpatrick, T. B., Pathak, M. A., Harber, L. C., et al (1974): An introduction to the problem of normal and abnormal responses of man’s skin to solar radiation. In: Sunlight and Man: Normal and Abnormal Photobiologic Responses, edited by M. A. Pathak, L. C. Harber, M. Seiji, et al. (T. B. Fitzpatrick, consulting editor), pp. 3–14. UniversityofTokyo Press, Tokyo.

    Google Scholar 

  25. Parrish, J. A., Pathak, M. A., and Fitzpatrick, T. B. (1971): Protection of skin from germicidal ultraviolet radiation in the operating room by topical chemicals. N. Engl. J. Med. 284:1257–1258.

    Article  PubMed  CAS  Google Scholar 

  26. Parrish, J. A., Pathak, M. A., and Fitzpatrick, T. B. (1972): Topical protection against germicidal radiation. Arch. Surg. 104:276–283.

    Article  PubMed  CAS  Google Scholar 

  27. Mathews-Roth, M. M., Pathak, M. A., Fitzpatrick, T. B. et al. (1970): Beta-carotene as a photoprotective agent in erythropoietic protoporphyria. N. Engl. J. Med. 282:1231–1234.

    Article  PubMed  CAS  Google Scholar 

  28. Mathews-Roth, M. M., Pathak, M. A., Fitzpatrick, T. B., et al. (1974): Beta-carotene as an oral photoprotective agent in erythropoietic protoporyria. J. AMA 228:1004–1008.

    CAS  Google Scholar 

  29. Mathews-Roth, M. M., Pathak, M. A., Fitzpatrick, T. B., et al. (1977): Beta-carotene therapy for etythropoietic protoporphyria and other photosensitivity diseases. Arch. Dermatol. 113:1229–1232.

    Article  PubMed  CAS  Google Scholar 

  30. Allison, J. L., O’Brien, R. L., and Hahn, F. E. (1965): DNA reactions with chloroquin. Science 149:1111–1113.

    Article  PubMed  CAS  Google Scholar 

  31. Allison, J. L., O’Brien, R. L., and Hahn, F. E. (1965): Nature of the deoxyribonucleic acid-chloroquine complex. In: Antimicrobial Agents and Chemotherapy, edited by G. L. Hobby, pp. 310–314. American Society for Microbiology, Ann Arbor, Michigan.

    Google Scholar 

  32. Percival, S. P., and Behrman, J. (1967): Ophthalmological safety of chloroquine. Br. J. Ophthalmol. 53:101–109.

    Article  Google Scholar 

  33. Rubin, M., Berstein, H. N., and Zvaifler, N. J. (1963): Studies on the pharmacology of chlorquine. Recommendations for the treatment of retinopathy. Arch. Ophthalmol. 70:470–481.

    Google Scholar 

  34. Sams, W. M., Jr. (1976): Chloroquine: its use in photosensitive eruptions. Int. J. Dermatol. 15:99–111.

    Article  PubMed  Google Scholar 

  35. Imbrie, J. D., Daniels, F., Bergeron, L., et al. (1959): Increased erythema threshold six weeks after a single exposure to sunlight plus oral methoxsalen. J. Invest. Dermatol. 32:331–337.

    Article  PubMed  CAS  Google Scholar 

  36. Everett, M. A., et al. (1965); Arch. Dermatol. 92:713–719 (1965).

    Article  PubMed  CAS  Google Scholar 

  37. Freeman, R. G. et al. (1966): J. Invest. Dermatol. 67:586–592 (1966).

    Google Scholar 

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© 1982 Plenum Press, New York

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Pathak, M.A., Fitzpatrick, T.B., Parrish, J.A. (1982). Topical and Systemic Approaches to Protection of Human Skin against Harmful Effects of Solar Radiation. In: Regan, J.D., Parrish, J.A. (eds) The Science of Photomedicine. Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8312-3_15

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  • DOI: https://doi.org/10.1007/978-1-4684-8312-3_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8314-7

  • Online ISBN: 978-1-4684-8312-3

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